“…Later reports from HypoCCS, with longer duration of follow-up, confirmed these earlier results 24,34,42 and showed no increase in all-site cancers: breast, prostate or colorectal primary cancers, or in the recurrence rates for pituitary adenomas or craniopharyngiomas. 42 In KIMS, no relationship between relapse of intracranial germ cell tumours and GH replacement was shown. 46,47 The risk of a second neoplasm in childhood cancer survivors was evaluated using data from GeNeSIS and HypoCCS.…”