Incidence of prenatal alcohol exposure in Prince Edward Island: a population-based descriptive study

Bryanton, Janet; Gareri, Joey; Boswall, Diane; McCarthy, Mary Jean; Fraser, Bonnie A.; Walsh, Donna; Freeman, Bridget; Koren, Gideon; Bigsby, Kathy

doi:10.9778/cmajo.20140011

Cited by 16 publications

(5 citation statements)

References 33 publications

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“…The prevalence of positive FAEE analyses for significant prenatal alcohol exposure in our cohort was 2.5%. This is lower than the 3.1%–4.4% (39–56 of 1,271 samples) reported in the Prince Edward Island population-based study 36 with the greater observed maximum FAEE level than ours, and higher than the 2% (11 of 505 specimens) in a cohort of Southwestern Ugandan women with the maximum FAEE level similar to ours. 37 The relatively low prevalence in our cohort may result from sample collection in a low-risk community hospital setting, as opposed to high-risk settings such as special institutional clinics offering structured services.…”

Section: Discussioncontrasting

confidence: 87%

Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study

Lee

Kim

Kwak³

et al. 2018

J Korean Med Sci

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BackgroundIn this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome.MethodsA total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry. The relationships between cumulative concentrations of nine species of FAEEs in meconium and birth parameters of growth (age-sex-specific centiles of head circumference [HC], weight, and length) and respective and combined birth outcomes of growth deficits (HC ≤ 10th centile, weight ≤ 10th centile, and length ≤ 10th centile) were determined.ResultsMultivariate logistic regression analysis demonstrated that higher cumulative concentrations of meconium FAEEs correlated with elevated risks for HC and length, both, 10th percentile or less (adjusted odds ratio [aOR], 2.94; 95% confidence interval [CI], 1.12–7.74; P = 0.029) and HC and weight and length, all of them, 10th percentile or less (aOR, 3.27; 95% CI, 1.12–9.59; P = 0.031).ConclusionThe elevated cumulative FAEEs in meconium were associated with combined growth deficits at birth, specifically HC and length, both, 10th percentile or less, which might be correlated with detrimental alcohol effects on fetal brain and bone development, suggesting a plausible alcohol-specific pattern of intrauterine growth restriction.

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Section: Discussioncontrasting

confidence: 87%

Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study

Lee

Kim

Kwak³

et al. 2018

J Korean Med Sci

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“…This prevalence rate should be considered as an estimate of the true rate of heavy in utero alcohol exposure. As seen in a previous study focusing on a high-risk obstetric unit, the prevalence rate in this type of population is significantly higher than the general population 32 . As the MIREC study cohort has been shown to have a higher level of education and annual household income than the Canadian average, due to the voluntary nature of participation in the study, this estimate most likely refers to a higher SES portion of the Canadian population.…”

Section: Discussionmentioning

confidence: 49%

Prevalence of Fetal Alcohol Exposure by Analysis of Meconium Fatty Acid Ethyl Esters; A National Canadian Study

Delano

Koren

Zack

et al. 2019

Sci Rep

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Our study aimed to estimate the prevalence of heavy fetal alcohol exposure through the analysis of meconium FAEEs as an objective biomarker of fetal exposure. We conducted a study on meconium samples collected nationwide through the Maternal-Infant Research on Environmental Chemicals (MIREC) Study Group. FAEE in meconium was quantified by an established headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (SPME GC-MS). Out of 1315 samples collected in 10 Canadian obstetric units coast to coast between 2008-2011, the estimated prevalence of positive meconium FAEE ranged between 1.16% and 2.40%, translating into at least 1800 new cases of FASD in Canada each year. Positive maternal self- reports of heavy alcohol use were tenfold lower (0.24%). Use of meconium FAEE revealed tenfold more cases of heavy exposure to maternal drinking than did maternal reports. The use of objective measures of maternal alcohol exposure is critical in accurately estimating risks and in monitoring effective prevention of FASD.

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“…It also found that women are were unable to access legal abortion services turn to dangerous methods to self-induce, including excessive drinking, falling down stairs, and asking friends, family or partners to punch and kick their stomachs (MacQuarrie, MacDonald & Chambers, 2014). PEI has a relatively high incidence of Fetal Alcohol Syndrome, which may be connected to the number self-inducing methods involving alcohol and the use of these methods by women unable to access safe and legal abortions (Bryanton, Gareri, Boswall, McCarthy, Fraser, Walsh, Freeman, Koren, & Bigsby, 2014).…”

Section: History Of Abortion: Canada and Peimentioning

confidence: 99%

Access to Abortion in PEI: How Problem Definitions, Public Pressure, and Canadian Federalism Shape Provincial Policy

Delaney¹

2020

CPoPP

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Incidence of prenatal alcohol exposure in Prince Edward Island: a population-based descriptive study

Cited by 16 publications

References 33 publications

Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study

Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study

Prevalence of Fetal Alcohol Exposure by Analysis of Meconium Fatty Acid Ethyl Esters; A National Canadian Study

Access to Abortion in PEI: How Problem Definitions, Public Pressure, and Canadian Federalism Shape Provincial Policy

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