Incidence of preeclampsia among asthmatic patients lower with theophylline

Dombrowski, Mitchell P.; Bottoms, Sidney F.; Boike, Guy M.; Wald, John J.

doi:10.1016/0002-9378(86)90804-5

Cited by 52 publications

(19 citation statements)

References 2 publications

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“…Intra uterine growth retardation was observed in 3 (5.7%) control and 4 (7.6%) in asthmatic women. Our data also supports study by Dombrowski et al 9 which showed that prevalence of low birth weight was 5.9% in control and 6.8% in asthmatic women. Hyperbilirubinemia was observed 9.6% in control as compared to 11.5% in asthmatic women.…”

Section: Discussionsupporting

confidence: 93%

“…Incidence of PPH was 7.6% in asthmatic group and 5.7% in control group in present study which also supports results of previous study by Dombrowski et al 9 where it was observed 5.3% non asthmatic and 7.0% asthmatic women had PPH. We also found increased evidence of delivery <37 weeks of gestation.…”

Section: Discussionsupporting

confidence: 92%

“…In our study we found pregnancy induced hypertension or preeclampsia in 11.54% control women vs 13% in asthmatic women. Our data is comparable to Dombrowski et al 9 , who also showed that of PIH was found in 11.2% in control women and 12.2% in pregnant asthmatics. We observed low birth weight neonates in 3 (5.7%) non asthmatic women vs 4 (7.6%) in asthmatic women.…”

Section: Discussionsupporting

confidence: 92%

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A study of neonatal and maternal outcomes of asthma during pregnancy

et al. 2013

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INTRODUCTIONAsthma is a common problem around the world with variable prevalence ranging from 1%-18% 1 in different age and geographical distribution. There are proximately 300 million affected individuals in the world. Study by Kwon HL et al suggests that approximately 4.1% of all pregnant women had experienced an asthma attack in previous year.2 Recent study in USA suggests 3.7-8.4% of women had asthma in 1997-2001, as compared to 3.2% according to data in 1988-1994. 3 There are growing prevalence and morbidity, due to asthma associated with pregnancy. Course of asthma in pregnancy is unpredictable, studies suggest that about 1/3rd have exacerbation, 1/3rd improve and rest of 1/3rd show no change in symptoms. 4,5 On the contrary asthma also had adverse effect on fetus and maternal outcomes in pregnant women. Various historical and prospective cohort studies have investigated the effect of maternal asthma on pregnancy outcomes, studies suggest that asthmatic women are more at risk of low birth neonate, preterm delivery, IUGR, congenital deformities and increased hospital stay. Maternal risks includes; preterm labor, preeclampsia, hypertension, antepartum and postpartum hemorrhage, increased cesarean section and forceps delivery. There are fewer studies on asthma & its ABSTRACTBackground: Asthma is a common problem all around the world with variable prevalence ranging from 1%-18% in different age and geographical distribution. There are proximately 300 million affected individuals. There are growing prevalence and morbidity, due to asthma associated with pregnancy. The course of asthma in pregnancy is unpredictable. Methods: 2400 consecutive pregnant women attending the antenatal clinic of S.P. Medical College and AG of Hospitals, Bikaner, were screened using asthma questionnaire translated in Hindi based on the questionnaire developed for International Union against Tuberculosis and Lung Disease. 52 patients diagnosed as asthma were subjected for PFT and classified according to clinical severity as per GINA guidelines, 2006. All subjects were followed till delivery and postpartum charts reviewed to see neonate and maternal outcome. Results: The prevalence of asthma during pregnancy was 2.1%, among them, 25 (48.1%) were categorized as having intermittent asthma, 6 (11.5%) with mild persistent asthma, 10 (19.2%) with moderate persistent asthma and 11 (21.2%) having severe persistent asthma. During the course of pregnancy, 36% had no change in the symptomatology, while (32.5%) experienced improvement and (32.5%) of worsening of asthma. 22 (42.31%) women were newly diagnosed during our study. There was no significant adverse maternal and fetal outcome in asthmatic group compared to control. Conclusions: Asthma is an under diagnosed and under treated disorder, especially during pregnancy and overall morbidity of asthma among women & neonates does not change during pregnancy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

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A study of neonatal and maternal outcomes of asthma during pregnancy

et al. 2013

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“…DOMBROWSKI et al [20] prospectively followed 153 pregnant females with asthma and 116 healthy control females and found a reduced incidence of pre-eclampsia among theophylline users, but only compared with females with asthma who did not use theophylline. They suggested that the ability of theophylline to reduce vascular reactivity and platelet aggregation via increasing cAMP may be responsible for this trend [20].…”

Section: Prospective Cohort Studiesmentioning

confidence: 99%

“…They suggested that the ability of theophylline to reduce vascular reactivity and platelet aggregation via increasing cAMP may be responsible for this trend [20]. However, another study found that pregnant females using theophylline were more likely to have an asthma exacerbation or develop pre-eclampsia than patients not using theophylline [57].…”

Section: Prospective Cohort Studiesmentioning

confidence: 99%

Asthma during pregnancy: mechanisms and treatment implications

Murphy

Gibson²,

Smith³

et al. 2005

European Respiratory Journal

155

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Asthma is becoming increasingly prevalent worldwide. Numerous historical and prospective cohort studies have investigated the effects of maternal asthma on pregnancy outcome; however, the data has been conflicting and many studies have not used standard classifications for asthma severity. Overall, the literature suggests that asthmatic females are more at risk of low birth weight neonates, pre-term delivery and complications such as preeclampsia, especially in the absence of actively managed asthma treated with inhaled corticosteroids. Pregnancy with a female foetus may particularly increase the risk of these outcomes.In addition, pregnancy has an effect on the course of asthma. The risk of an exacerbation requiring medical intervention may be as high as 50% in females with severe asthma and this may further increase the risk of poor outcomes, particularly low birth weight and pre-term delivery.The mechanisms responsible for changes in asthma with pregnancy, or alterations in pregnancy outcomes due to asthma have not been thoroughly explored. Maternal inflammatory pathways may contribute to reduced foetal growth through alterations in placental function.Asthma treatment, by reducing maternal inflammation and preventing exacerbations, is safe for use in pregnant females and contributes to improved outcomes for both mother and foetus.

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The Interrelations Between Asthma, Pregnancy, and Lactation

Incaudo

Schätz

1994

Bronchial Asthma

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Incidence of preeclampsia among asthmatic patients lower with theophylline

Cited by 52 publications

References 2 publications

A study of neonatal and maternal outcomes of asthma during pregnancy

A study of neonatal and maternal outcomes of asthma during pregnancy

Asthma during pregnancy: mechanisms and treatment implications

The Interrelations Between Asthma, Pregnancy, and Lactation

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