Incidence of pre-eclampsia in first full-term pregnancies preceded by abortion

Beck, Ian

doi:10.3109/01443618509079148

Cited by 11 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies examining the association of SAB or IAB with hypertension and pre-eclampsia in a subsequent pregnancy have reported conflicting results. [27][28][29][30][31] SAB and IAB were found to be associated with reduced pre-eclampsia risk in some studies, 27,28,30 but not others. 30,32 Certain studies have shown this association to be dependent on timing of abortion 33 or the woman's parity.…”

Section: Commentmentioning

confidence: 89%

Adverse Pregnancy Outcomes among Women with Prior Spontaneous or Induced Abortions

et al. 2013

View full text Add to dashboard Cite

OBJECTIVE To determine whether prior spontaneous (SAB) or induced (IAB) abortions, or the inter-pregnancy interval are associated with subsequent adverse pregnancy outcomes in nulliparous women. METHODS We performed a secondary analysis of data collected from nulliparous women enrolled in a completed trial of vitamins C and E or placebo for preeclampsia prevention. Adjusted odds ratios for maternal and fetal outcomes were determined for nulliparous women with prior SABs and IABs as compared to primigravid participants. RESULTS Compared with primigravidas, women with one prior SAB were at increased risk for perinatal death (OR 1.5; 95% CI 1.1–2.3) in subsequent pregnancies. Two or more SABs were associated with an increased risk for spontaneous preterm birth (OR 2.6, 95% CI 1.7–4.0), preterm PROM (OR 2.9, 95% CI 1.6–5.3) and perinatal death (OR 2.8, 95% CI 1.5–5.3). Women with one previous IAB had higher rates of spontaneous preterm birth (OR 1.4, 95% CI 1.0–1.9) and preterm PROM (OR 2.0, 95% CI 1.4–3.0). An inter-pregnancy interval less than 6 months after SAB was not associated with adverse outcomes. CONCLUSION Nulliparous women with a history of SAB or IAB, especially multiple SABs, are at increased risk for adverse pregnancy outcomes.

show abstract

Section: Commentmentioning

confidence: 89%

Adverse Pregnancy Outcomes among Women with Prior Spontaneous or Induced Abortions

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Determining whether the decrease in risk from a first to a second pregnancy is restricted to women with a prior live birth or if a prior pregnancy, regardless of outcome, confers similar protection has been the topic of several studies. In general, studies have shown a lower risk of preeclampsia associated with induced abortion (IA) (4-7) but not spontaneous abortion (SAB) (5)(6)(7)(8), although findings have been inconsistent (4,9,10).…”

mentioning

confidence: 99%

Induced Abortions and the Risk of Preeclampsia Among Nulliparous Women

Parker¹,

Gissler²,

Ananth³

et al. 2015

Am. J. Epidemiol.

View full text Add to dashboard Cite

Induced abortion (IA) has been associated with a lower risk of preeclampsia among nulliparous women, but it remains unclear whether this association differs by method (either surgical or medical) or timing of IA. We performed a nested case-control study of 12,650 preeclampsia cases and 50,600 matched control deliveries identified in the Medical Birth Register of Finland from 1996 to 2010. Data on number, method, and timing of IAs were obtained through a linkage with the Registry of Induced Abortions. Odds ratios and 95% confidence intervals were calculated. Overall, prior IA was associated with a lower risk of preeclampsia, with odds ratios of 0.9 (95% confidence interval (CI): 0.9, 1.0) for 1 prior IA and 0.7 (95% CI: 0.5, 1.0) for 3 or more IAs. Differences in the associations between IA and preeclampsia by timing and method of IA were small, with odds ratios of 0.8 (95% CI: 0.6, 1.1) for late (≥12 gestation weeks) surgical abortion and 0.9 (95% CI: 0.7, 1.2) for late medical abortion. There was no association between IA in combination with a history of spontaneous abortion and risk of preeclampsia. In conclusion, prior IA only was associated with a slight reduction in the risk of preeclampsia.

show abstract

“…According to previous studies, repeated IAs may cause uterine adhesion, placenta previa, and pelvic inflammation, which impact subsequent pregnancies [8]. However, studies have shown a lower risk of PE associated with IAs in primiparous women [9][10][11][12][13]. A history of light endometrium injuries, such as biopsy and curettage may increase the success rate of implantation in assisted reproductive techniques [14].…”

Section: Introductionmentioning

confidence: 99%

Human Uterine Decidual NK Cells in Women with a History of Early Pregnancy Enhance Angiogenesis and Trophoblast Invasion

Jia

2020

BioMed Research International

View full text Add to dashboard Cite

Objective. The present study aimed to identify changes in decidual natural killer (dNK) cells and related cytokines in women who have undergone induced abortions (IAs). The effects of dNK cells on subsequent pregnancies remain unknown. Accordingly, we sought to investigate whether a history of early pregnancy can change dNK cells and facilitate their role in the regulation of angiogenesis and trophoblast invasion. Materials and Methods. dNK cells were obtained from primiparous women who had undergone IA(s) prior to this study and primiparous women who had never been pregnant before this IA (control). Real-time polymerase chain reaction (PCR) was used to measure the mRNA levels of IFN-γ, IP-10, VEGF, and PLGF in dNK cells. The levels of these cytokines were quantified using the enzyme-linked immunosorbent assay. HUVEC and HTR-8/SVneo cells were used to evaluate the angiogenesis, migration, and invasion activities influenced by dNK cells. Results. In dNK cells, the mRNA level of IFN-γ was higher in the control group than that in the IA group. The secretion of IP-10 and VEGF was higher in the IA group compared to the control group. After coculturing with the dNK supernatant, the HTR-8/SVneo cells exhibited better invasiveness and migration in the IA group than those in the control group. Angiogenesis assay demonstrated that dNK cells from IA group might help HUVEC attain better tube formation ability. Conclusion. The findings of this study suggest that a history of early pregnancy has an impact on dNK cells. These trained dNK cells can regulate angiogenesis and trophoblast invasion and migration by promoting the production of certain cytokines.

show abstract

Incidence of pre-eclampsia in first full-term pregnancies preceded by abortion

Cited by 11 publications

References 3 publications

Adverse Pregnancy Outcomes among Women with Prior Spontaneous or Induced Abortions

Adverse Pregnancy Outcomes among Women with Prior Spontaneous or Induced Abortions

Induced Abortions and the Risk of Preeclampsia Among Nulliparous Women

Human Uterine Decidual NK Cells in Women with a History of Early Pregnancy Enhance Angiogenesis and Trophoblast Invasion

Contact Info

Product

Resources

About