Incidence of Pituitary Adenomas in Northern Finland in 1992–2007

Abstract

The final cohort consisted of 355 PAs. The incidence rates of the Oulu University Hospital regional district were used as a reference to assess the applicability of our case finding over the rest of NFi. Incidence rates of all PA subgroups except microprolactinomas were statistically equal between these areas; thus, all presented SIRs are based on the NFi's cohort except Oulu University Hospital regional district-based prolactinomas and PAs overall. Overall SIR of PAs was higher (4.0 per 100,000) than in previous reports. Prolactinomas had the highest SIR: 2.2 per 100,000, followed by clinically nonfunctioning PAs (1.0) and GH-secreting (0.34), ACTH-secreting (0.17), and TSH-secreting (0.03) PAs. The gender-specific SIR was 2.2 per 100,000 in males and 5.9 per 100,000 in females. Pituitary apoplexy occurred as a presenting symptom in 11% of clinically nonfunctioning PA patients. The SIR of incidentally discovered PAs increased significantly from 1992-1999 to 2000-2007 (0.59 to 1.6, respectively; P < 0.01), which accounted for the perceived increasing trend in the overall SIR of PAs (3.8 to 4.2; P > 0.05).

Neuro-ophthalmic and clinical characteristics of brain tumours in a tertiary hospital in Ghana

“…The greater number of females in this study may be due to general female preponderance of meningiomas and pituitary adenomas. 1,3,8,13,14,15 The disparity in sex distribution between this study and the Nigerian studies may also be attributed to the bulk (83.3%) of tumours in this study being meningiomas and pituitary adenomas whereas this group of tumours constituted 52.1% and 39.8% in Onapoya's 2 and Idowus's series 13 respectively.…”

DIAGNOSIS OF ENDOCRINE DISEASE: Diagnostic approach to TSH-producing pituitary adenoma

“…Clinical manifestations of pituitary adenomas imply a much lower prevalence. A series of studies on well-defined populations report a prevalence of 75.7-94/100 000 inhabitants of clinically overt cases (30,31,32), and the reported incidence is 3.9-4.1 cases/100 000 inhabitants per year (31,33,34). Pituitary adenomas are one of the most frequently occurring intracranial tumors, and the occurrence of pituitary adenomas seems to be similar despite geographic or ethnic differences (29,35,36).…”

“…TSHomas are the rarest among the pituitary adenomas, only representing 0.7-0.94% of all pituitary adenomas (31,33,34). A comprehensive study of the Swedish national Pituitary Registry found a national prevalence of 2.8 clinically overt cases per million inhabitants and an incidence rate of 0.15 cases per million inhabitants per year (19).…”

Outcomes of transsphenoidal surgery in prolactinomas: improvement of hormonal control in dopamine agonist-resistant patients

“…Prolactinomas are the most frequent pituitary tumors, with a prevalence estimated to be 35-60 cases per 100 000 individuals (1,2,3). Women are predominantly affected and generally have symptoms of hypogonadism and/or galactorrhea (4,5), whereas men are more likely to present with larger adenomas at the time of diagnosis and show drug resistance (6).…”