Incidence of pertussis in persons ≤15 years of age in Valencia, Spain: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults

Díez-Domingo, Javier; Ballester, Alfredo; Baldó, José-María; Planelles, Marı́a-Victoria; Villarroya, José V.; Alvarez, Trinidad; Peidró, M. Carmen; Calero, P.; Garcés, Maria de Mar Fernández; Sorribes, Ignacio; Graullera, M.; Jubert, Angels; San-Martı́n, M.; González, Antonio

doi:10.1016/j.jinf.2004.03.003

Cited by 14 publications

(8 citation statements)

References 27 publications

(11 reference statements)

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“…60 Table 3 summarizes data from 8 studies of the prevalence of B pertussis in outpatients with prolonged or bothersome cough, largely in primary care. 17,[64][65][66][67][68][69][70] Three studies enrolled adults and children; 4, children only; 68 The prevalence of B pertussis is summarized in the forest plot in Figure 5. While there was significant heterogeneity when including all studies, this was primarily due to heterogeneity in the 4 studies of children only.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

Marchello

Dale

Thai

et al. 2016

The Annals of Family Medicine

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PURPOSE Community-acquired pneumonia (CAP), acute cough, bronchitis, and lower respiratory tract infections (LRTI) are often caused by infections with viruses or Streptococcus pneumoniae. The prevalence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. We set out to derive prevalence information from the existing literature. METHODSWe performed a systematic review of MEDLINE for prospective, consecutive-series studies reporting the prevalence of M pneumoniae, C pneumoniae, L pneumophila and/or B pertussis in outpatients with cough, acute bronchitis, LRTI, or CAP. Articles were independently reviewed by 2 authors for inclusion and abstraction of data; discrepancies were resolved by consensus discussion. A meta-analysis was performed on each pathogen to calculate the pooled prevalence estimates using a random effects model of raw proportions.RESULTS Fifty studies met our inclusion criteria. While calculated heterogeneity was high, most studies reported prevalence for each pathogen within a fairly narrow range. In patients with CAP, the overall prevalences of M pneumoniae and C pneumoniae were 10.1% (95% CI, 7.1%-13.1%) and 3.5% (95% CI, 2.2%-4.9%), respectively. Consistent with previous reports, M pneumoniae prevalence peaked in roughly 6-year intervals. Overall prevalence of L pneumophila was 2.7% (95% CI, 2.0%-3.4%), but the organism was rare in children, with only 1 case in 1,765. In patients with prolonged cough in primary care, the prevalence of B pertussis was 12.4% (95% CI, 4.9%-19.8%), although it was higher in studies that included only children (17.6%; 95% CI, 3.4%-31.8%).CONCLUSIONS Atypical bacterial pathogens are relatively common causes of lower respiratory diseases, including cough, bronchitis, and CAP. Where surveillance data were available, we found higher prevalences in studies where all patients are tested for these pathogens. It is likely that these conditions are underreported, underdiagnosed, and undertreated in current clinical practice.

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Section: Resultsmentioning

confidence: 99%

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

Marchello

Dale

Thai

et al. 2016

The Annals of Family Medicine

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“…A number of studies have found an incidence of pertussis in primary care and emergency department settings in the range 10-30%. [4][5][6][7][8][9] A sample size of 200 was sufficient to estimate the incidence of B. pertussis infection with 95% confidence limits of ± 4% if the true incidence was 10%, and ± 6% if the true incidence was 30%. recruitment Potential participants were invited to participate by members of the general practice team (GP, practice nurse, administration staff).…”

Section: Participantsmentioning

confidence: 99%

When is acute persistent cough in school-age children and adults whooping cough?

Philipson¹,

Goodyear‐Smith²,

Grant³

et al. 2013

Br J Gen Pract

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“…Pertussis has significant morbidity and relatively high mortality rates, particularly in children <1 year old. In European countries with high vaccination coverage (>95 %) amongst children, the distribution of cases appears to have shifted to adolescents and adults (Diez-Domingo et al , 2004; Gil et al , 2001).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of reported cases of pertussis: epidemiological study in a large city in Spain

Solano

Rius

Simón

et al. 2014

Journal of Medical Microbiology

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We retrospectively analysed the incidence rate of reported cases of pertussis in Barcelona during 2009-2012 according to age, sex, type of medical centre and vaccination status. We included 748 confirmed or suspected cases, 613 (82.0 %) of which were confirmed by laboratory testing and the remaining 135 (18.0 %) by epidemiological evidence. The highest reported incidence of pertussis was amongst ,1 year olds [96.1 per 100 000 person-years, 95 % confidence interval (CI): 84.3-109.1]. The majority of confirmed and suspected cases were reported in 2011 and 2012, and the total incidence (confirmed or suspected) was 6.3 (95 % CI: 5.6-6.9) and 4.2 (95 % CI: 3.6-4.7) per 100 000 person-years, respectively. Incidence increased significantly (P50.001) in 2011-2012 compared with 2009. Most confirmed cases occurred in children ,1 year old (87.9 %). Cases were confirmed by real-time (RT)-PCR (87.5 %; 95 % CI: 81.3-87.6) and bacterial culture (13.7 %; 95 % CI: 11.0-17.1). We recommend performing RT-PCR in suspected cases with no epidemiological link to a confirmed case.

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Incidence of pertussis in persons ≤15 years of age in Valencia, Spain: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults

Cited by 14 publications

References 27 publications

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

When is acute persistent cough in school-age children and adults whooping cough?

Evaluation of reported cases of pertussis: epidemiological study in a large city in Spain

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