Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: A double-blind, randomized study

Larsson, Per‐Göran; Platz-Christensen, Jens-Jörgen; Thejls, Henning; Forsum, Urban; Påhlson, Carl

doi:10.1016/0002-9378(92)91838-2

Cited by 160 publications

(95 citation statements)

References 13 publications

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“…The association observed between induced abortion and risk of subsequent ectopic pregnancy could be the consequence of uterine injuries consec-utive to this procedure, either inflammatory lesions or asymptomatic postsurgical ascending infections (symptomatic infections were considered in our analysis). Recent studies (e.g., Larson et al 22) have pointed out the necessity of better defining the women undergoing abortion who are at risk of pelvic infections and who should receive prophylactic treatment with antibiotics. Our results constitute a supplementary argument for doing so.…”

Section: Discussionmentioning

confidence: 99%

Risk of ectopic pregnancy and previous induced abortion.

Tharaux-Deneux

Bouyer²,

Job‐Spira³

et al. 1998

Am J Public Health

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OBJECTIVES: This study investigated the role of prior history of induced abortion in subsequent ectopic pregnancies. METHODS: Data from two French case-control studies were used to examine the effect of induced abortion on ectopic pregnancy risk. Case patients (n = 570) were women admitted for ectopic pregnancy during the study period; controls (n = 1385) were women who delivered in the same center. RESULTS: The analysis among women with no previous ectopic pregnancy showed that, after control for the main ectopic pregnancy risk factors, prior induced abortion was associated with an increased risk of ectopic pregnancy (odds ratio [OR] = 1.5, 95% confidence interval [CI] = 1.0, 2.0); there was a significant trend between number of previous induced abortions and ectopic pregnancy risk (ORs = 1.4 for 1 previous induced abortion and 1.9 for 2 or more). CONCLUSIONS: This study suggests that induced abortion may be a risk factor for ectopic pregnancy for women with no previous ectopic pregnancy, particularly in the case of women who have had several induced abortions.

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Section: Discussionmentioning

confidence: 99%

Risk of ectopic pregnancy and previous induced abortion.

Tharaux-Deneux

Bouyer²,

Job‐Spira³

et al. 1998

Am J Public Health

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“…Bacterial vaginosis, one of the most common gynecologic infections in women of reproductive age, has been associated with such important problems as premature delivery [1][2][3][4] , endometritis and pelvic inflammatory disease [5][6][7] . In addition, bacterial vaginosis has been associated with increased risk of human immunodeficiency virus (HIV) acquisition among pregnant and postnatal women in Malawi 8 .…”

mentioning

confidence: 99%

A Multicenter Study of Bacterial Vaginosis in Women With orat Risk for Human Immunodeficiency Virus Infection

Warren¹,

Klein

Sobel

et al. 2000

Infectious Diseases in Obstetrics and Gynecology

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Background: Bacterial vaginosis is a common gynecologic infection that has been associated with a variety of gynecologic and obstetric complications, including pelvic inflammatory disease, postabortal infection and premature delivery. Recent studies suggest that bacterial vaginosis may increase a womanÃ¢Â€Â™s risk for human immunodeficiency virus (HIV). We undertook this study to assess whether the prevalence and characteristics of bacterial vaginosis differed according to HIV status in high-risk US women

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“…BV is a significant alteration of the vaginal microflora because it is associated with a variety of pelvic infections in both the obstetric and gynecologic patient [1][2][3] . However, restoration of a healthy vaginal microflora in patients with BV has been difficult.…”

mentioning

confidence: 99%

The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

Aroutcheva

Simões

Shott

et al. 2000

Infectious Diseases in Obstetrics and Gynecology

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Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95-20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus. Results: Clindamycin concentrations between 1.95-31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml. Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.

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Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: A double-blind, randomized study

Cited by 160 publications

References 13 publications

Risk of ectopic pregnancy and previous induced abortion.

Risk of ectopic pregnancy and previous induced abortion.

A Multicenter Study of Bacterial Vaginosis in Women With orat Risk for Human Immunodeficiency Virus Infection

The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

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