Incidence of Parkinson disease and parkinsonism in three elderly populations of central Spain

Benito‐León, Julián; Bermejo‐Pareja, Félix; Morales-González, José Manuel; Porta‐Etessam, Jesús; Trincado, Rocío; Vega, Saturio; Louis, Elan D.

doi:10.1212/01.wnl.0000113727.73153.68

Cited by 170 publications

(171 citation statements)

References 40 publications

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“…Some studies, including our investigation, found a decline in incidence rates for the oldest old,14, 15, 16, 17, 18 and others did not 11, 12, 13. However, varying definitions and small sample sizes make comparisons difficult 1.…”

Section: Discussionmentioning

confidence: 51%

“…Incidence rates are also low for those aged 50‐59 and increase sharply afterward. Age‐specific peaks differ between studies, however, ranging from 80.4 to 678 new cases/100 000 person‐years 11, 12, 13, 14, 15, 16, 17, 18, 19. German data on prevalence and incidence are rare, outdated, and had been designed primarily as door‐to‐door surveys 1.…”

Section: Introductionmentioning

confidence: 99%

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Parkinson's disease in Germany: prevalence and incidence based on health claims data

2016

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BackgroundIn Germany, epidemiological information on Parkinson's disease (PD) is rare and outdated. Considering aging populations, current prevalences and incidence rates about this age‐related disease would be important for adequate public health planning.MethodsWe used newly available health claims data sets from the largest German health insurer dating 2004‐2007 and 2007‐2010 with an analysis population in the base years of 491 038 persons aged 50 and older. Quarter‐specific information about ICD‐10 diagnoses and PD drug prescriptions from the inpatient and outpatient sectors was used to validate PD cases. Estimations were presented for two validation strategies relying on repeated PD diagnoses (SIa) and on one PD diagnosis followed by at least one PD drug prescription (SIb).ResultsThe standardized prevalence was 797 (SIb) to 961/100 000 persons (SIa), showing an age‐specific increase up to category 85‐89 and a decline thereafter. The standardized incidence rate was 192 to 229/100 000 person‐years with a similar age‐specific shape. Prevalences and incidences rates were higher for men compared to women in regard to age.ConclusionsHealth claims data are found to be suitable for PD assessment using the repeated diagnoses or PD drug prescriptions as necessary criteria.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Parkinson's disease in Germany: prevalence and incidence based on health claims data

2016

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“…Detailed of the study population and sampling methods have been published elsewhere. [4][5][6] Briefly, subjects were selected by means of census lists from three different populations in central Spain in 1994-1995. Data from this baseline cross-sectional evaluation were used for this study.…”

Section: Study Populationmentioning

confidence: 99%

“…5,6 PD was defined by the presence of 2 cardinal signs of bradykinesia, resting tremor, rigidity and impairment of postural reflexes (or 1 cardinal sign in those on antiparkinsonian medication) and exclusion of other causes of parkinsonism. Only subjects with idiopathic PD were included in the study (Table 1).…”

Section: Diagnosis Of Parkinson's Disease and Diabetesmentioning

confidence: 99%

Association between Parkinson's disease and diabetes: Data from NEDICES study

et al. 2017

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“…Data for these analyses were derived from the Neurological Disorders in Central Spain (NEDICES) study, a longitudinal, population-based survey of the prevalence, incidence, and determinants of major ageassociated conditions of the elderly, including Parkinson's disease, essential tremor, stroke, and dementia [16][17][18][19][20][21][22][23][24][25]. Detailed accounts of the study population and sampling methods have been published [23][24][25].…”

Section: Study Populationmentioning

confidence: 99%

Statins and Cognitive Functioning in the Elderly: A Population-Based Study

Benito-León

Louis

Vega³

et al. 2010

JAD

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Abstract. In a 2009 Cochrane review, the authors concluded that there is good evidence that statins, given in late life to people at risk of vascular disease, have no effect in preventing Alzheimer's disease or dementia. A related issue, which remains unclear, is whether statins improve cognitive function. While some studies have shown a beneficial effect of statins on cognitive function, others have observed mild detrimental effects on cognition. Our aim was to assess cognitive function in community-dwelling elderly participants treated with statins compared with their untreated counterparts (i.e., controls) living in the same population. 137 population-dwelling participants who were receiving statins and 411 matched controls age 65 years (median = 72 years) in central Spain (the Neurological Disorders in Central Spain [NEDICES] study) underwent a neuropsychological assessment, including tests of global cognitive performance, frontal-executive function, verbal fluency, and memory. Median duration of statin treatment was 2 years. Of 137 participants receiving statins, 53 (38.7%) were taking pravastatin, 38 (27.7%) simvastatin, 37 (27.0%) lovastatin, 6 (4.4%) fluvastatin, and 3 (2.2%) atorvastatin. Although initial univariate analyses indicated some differences, after adjusting for age, gender, education, depressive symptoms, premorbid intelligence, medications that potentially affect cognitive function, and blood cholesterol levels, statin users and controls performed similarly on all neuropsychological tests. In this population-based sample, elderly participants treated with statins and untreated controls performed similarly in all tested cognitive areas. These results do not support a positive benefit of statins on cognition.

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Incidence of Parkinson disease and parkinsonism in three elderly populations of central Spain

Abstract: Incidence estimates of PD based on two-phase investigation methodology are higher than those based on other approaches. Men had a risk of developing PD that was twice that of women. A large proportion of PD patients may never seek neurologic attention.

Cited by 170 publications

References 40 publications

Parkinson's disease in Germany: prevalence and incidence based on health claims data

Parkinson's disease in Germany: prevalence and incidence based on health claims data

Association between Parkinson's disease and diabetes: Data from NEDICES study

Statins and Cognitive Functioning in the Elderly: A Population-Based Study

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