Incidence of other previously diagnosed primary malignant tumor types in breast cancer patients: a retrospective statistical evaluation in 2007-2016

The Melanoma and Breast Cancer Association: An Overview of their ‘Second Primary Cancers’ and the Epidemiological, Genetic and Biological correlations

“…A meta-analysis in 2015 of thirteen studies combining 1,346,671 primary female breast cancer survivors found a 17% increase in the risk of developing a new primary non-breast cancer in comparison to those that had never received a breast carcinoma diagnosis (22). Sites of second primary cancers consistently reported include the soft tissue (sarcoma) (SIR range 2.25-13) (11,(23)(24)(25), ovary (SIR range 1.6-5.7) (11,12,18,21,(23)(24)(25)(26)(27)(28)(29)(30)(31), thyroid gland (SIR range 1.54-1.62) (12,21,24,32), endometrium (SIR range 1.3-1.52) (11,12,21,23,24,27,29,30,32,33), leukaemia (SIR range 1.2-3.1) (11,12,23,29) and lung (SIR range 1.2-1.24) (18,19,21,25,29,32,34). Studies have postulated the likely causes for these associations.…”