Incidence of orbital, conjunctival and lacrimal gland malignant tumors in USA from Surveillance, Epidemiology and End Results, 1973-2009

Hassan, Waleed M.; Bakry, Mohammed; Alfaar, Ahmad Samir

doi:10.18240/ijo.2016.12.18

Cited by 22 publications

(19 citation statements)

References 27 publications

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“…We suspect the increasing incidence of all conjunctival tumors in our population was secondary to improved provider awareness and documentation of benign lesions, as the study design relied on what was reported in the medical records. While other studies reported increasing incidences of conjunctival melanoma, OSSN, and lymphoma,[6 16 23 24] we did not find increasing rates of these specific tumors. Although our incidence rate from 2010–2015 appeared to decrease, we suspect this was an artifact, possibly explained by more patients seeking routine and primary eye care at private optometry offices, which are not captured in the REP database.…”

Section: Discussioncontrasting

confidence: 95%

Population-based incidence of conjunctival tumours in Olmsted County, Minnesota

2018

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Section: Discussioncontrasting

confidence: 95%

Population-based incidence of conjunctival tumours in Olmsted County, Minnesota

2018

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“…However, other analyses have suggested that sex is not associated with conjunctival or corneal tumor incidence or prognosis [ 20 ]. No specific explanation as to why men are at a higher risk of such tumors has been defined [ 21 ], but relevant risk factors could include differences in UV exposure, outdoor activity, hormones, study populations, or analyzed tumor types. Further study of the relative incidence of malignant conjunctival tumors in males and females is thus warranted.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data

Diao

Huo

et al. 2020

BioMed Research International

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Epidemiological studies of malignant primary conjunctival tumors are rare. We extracted data pertaining to primary site-labeled conjunctival cancer patients present within the Surveillance, Epidemiology, and End Results (SEER) database from 1992 to 2001 and from 2002 to 2011. The Kaplan-Meier approach was used for comparisons of overall survival (OS) between patients, while OS-related risk factors were identified via a Cox proportional hazards regression approach. We then constructed a nomogram that could be used to predict the 3- and 5-year OS, with the accuracy of this predictive model based on receiver operating characteristic (ROC) curve. We observed a significant reduction in age-adjusted incidence of conjunctival cancer in the 50-69-year-old age group of the 2002-2011 cohort relative to the 1992-2001 cohort (APC, P<0.05). There were no significant differences in OS between the 1992-2001 and 2002-2011 conjunctival cancer patient cohorts. Being ≥30 years old (P<0.05), male (P<0.001), single (P<0.05), divorced (P<0.001), or widowed (P<0.001) were all associated with an increased OS-related risk of primary conjunctival cancer (1992-2011). Our nomogram was able to accurately predict 3- and 5-year OS in conjunctival cancer patients. In verification mode, the 3-year area under the curve (AUC) was 0.697 and the 5-year AUC was 0.752. We found that age, sex, and marital status were all associated with primary conjunctival cancer survival. Our results further suggest that conjunctival cancer incidence and survival rates have been relatively stable over the last two decades, and using these data, we were able to generate a satisfactory risk prediction model for this disease.

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“…Figure 1 shows different patterns in annual incidence rates of first and second primaries where first primary malignancies showed multiphasic pattern and second primary malignancies showed a steady increase. The potential causes for first primary malignancies were discussed elsewhere [ 32 ]. Our paper presents a new pattern in second ocular and its adnexal malignancies that may not be influenced by the same factors.…”

Section: Discussionmentioning

confidence: 99%

Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body

Alfaar

Saad

KhalafAllah

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose The eye and its adnexal structures can give rise to first or consecutive primary malignancies or to encounter metastasis. Our aim was to define the characteristics of the second primary neoplasms affecting the eye and its adnexa and find the risk modifying factors for them after malignancies elsewhere in the body. Methods We have queried the Surveillance, Epidemiology and End-Results "SEER"-9 program of the National Cancer Institute for the malignancies of the eye and its adnexa that occurred between 1973 and 2015. The malignancies were ordered chronologically according to their incidence: first or second primary malignancies. The tumors were classified according to ICD-O-3 classification. Standardized incidence ratios (SIR) and survival probabilities were calculated for subgroups. Results Among 3,578,950 cancer patients, 1203 experienced a second malignancies of the eye and its adnexa. The first malignancy was diagnosed between 50 and 69 years of age in 58.94% of them. The eyelid showed 280 events, while 50 in lacrimal gland, 181 in the orbit, 21 in the overlapping lesions, 15 in optic nerve, 148 in the conjunctiva, 9 in the cornea, 6 in the Retina, 379 in the choroid, and 93 in the ciliary body. The SIR of a second malignancy after a prior non-Hodgkin lymphoma was 2.42, and in case of previous skin carcinomas it was 3.02, melanoma of skin, and 2.13 and 1.58 in oral cavity/pharynx malignancies. The second ocular and adnexal neoplasms increased steadily over the 5-year periods on contrary to first primary neoplasms. The survival of patients affected with first ocular and adnexal neoplasms was significantly higher than those with second ocular and adnexal neoplasms. On the other side, second primary ocular and adnexal tumors showed a better survival than second primary malignancies elsewhere. Conclusions The epidemiological differences between first and second ocular and adnexal primaries suggest different underlying mechanisms. Careful ocular examination should be integrated in the long-term follow-up plan of cancer patients. Special attention should be given to patients with non-Hodgkin's lymphoma and melanoma as first primary.

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Incidence of orbital, conjunctival and lacrimal gland malignant tumors in USA from Surveillance, Epidemiology and End Results, 1973-2009

Cited by 22 publications

References 27 publications

Population-based incidence of conjunctival tumours in Olmsted County, Minnesota

Population-based incidence of conjunctival tumours in Olmsted County, Minnesota

Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data

Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body

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