Incidence of Oral Cancer Occult Metastasis and Survival of T1-T2N0 Oral Cancer Patients

El-Naaj, Imad Abu; Leiser, Yoav; Shveis, M.; Sabo, Edmond; Peled, Micha

doi:10.1016/j.joms.2011.02.012

Cited by 60 publications

(45 citation statements)

References 31 publications

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“…Regional recurrence was the most common type of recurrence for early-stage OTSCC. Some researchers have reported occult cervical metastasis in an incidence ranging from 16% to 26% [7,11]. The incidence of regional recurrence in our study was 15.5%, comparable with other studies [7,11].…”

Section: Discussionsupporting

confidence: 90%

“…In our study, the local recurrence rate of 10.3% was similar to those reported in the literature [5,13,[29][30][31]. Some studies have demonstrated that pathological variables such as DOI, surgical margin, and POI could be reliable parameters for local recurrence in early-stage OTSCC [8][9][10][11][20][21][22][23][24][25][26][27][28][29][30][31]. We observed that a higher incidence of local recurrence was associated with POI, NAC, closed surgical margin, and perineural invasion.…”

Section: Discussionsupporting

confidence: 88%

“…Some researchers have reported occult cervical metastasis in an incidence ranging from 16% to 26% [7,11]. The incidence of regional recurrence in our study was 15.5%, comparable with other studies [7,11]. In univariate analysis, only the histological grade was correlated with regional recurrence; however, only 5 patients had moderately or poorly differentiated SCC.…”

Section: Discussionsupporting

confidence: 88%

“…Treatment failure in OTSCC patients is most frequently due to local and regional recurrences [4,5]. The prognosis also depends or varies with nodal involvement, tumor thickness, and the status of the surgical margins [4][5][6][7][8][9][10][11]. In particular, the most significant prognostic factor in OTSCC is the presence of metastatic disease in the cervical lymph nodes [7,9,11].…”

Section: Introductionmentioning

confidence: 99%

“…The prognosis also depends or varies with nodal involvement, tumor thickness, and the status of the surgical margins [4][5][6][7][8][9][10][11]. In particular, the most significant prognostic factor in OTSCC is the presence of metastatic disease in the cervical lymph nodes [7,9,11]. Unfortunately, this metastatic disease is quite often subclinical or occult at the time of diagnosis and treatment; therefore, controversy exists regarding the treatment of the clinically negative neck in patients with T1-2N0 OTSCC.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Yanamoto

Yamada

Takahashi

et al. 2013

Pathol. Oncol. Res.

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Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate.The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3% (6/58 patients) and 15.5% (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7%, which was significantly lower than that (96.2%) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone.

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Section: Discussionsupporting

confidence: 90%