Incidence of non-B subtypes of HIV-1 in Galicia, Spain: high frequency and diversity of HIV-1 among men who have sex with men

Cuevas, María Teresa; Fernández-García, Aurora; Sánchez-García, Ana María; González-Galeano, M.; Pinilla, Milagros; Sánchez-Martínez, Mónica; Garcia, Valentina E.; Pérez-Álvarez, Lucı́a

doi:10.2807/ese.14.47.19413-en

Cited by 17 publications

(10 citation statements)

References 10 publications

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“…Similarly, a study of Shijiazhuang MSM showed that CRF01_AE accounted for 52.9% of infections (35.3% for subtype B) between 2008 and 2009 (18). This condition of the predominance of CRF01_AE is distinct from the MSM epidemic in the Western world, where subtype B of U.S. and European origin predominates (5,30), and may be related to a recent upsurge of the HIV epidemic in southeastern Asia (29).…”

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confidence: 99%

Reconstituting the Epidemic History of HIV Strain CRF01_AE among Men Who Have Sex with Men (MSM) in Liaoning, Northeastern China: Implications for the Expanding Epidemic among MSM in China

Han

et al. 2012

J Virol

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dHIV CRF01_AE accounted for 84% of the recent infections among men who have sex with men (MSM) in Liaoning Province of northeastern China. CRF01_AE strains were grouped into two distinct clusters (designated clusters 1 and 2) that were also detected in other regions in China. Phylodynamics study revealed that these two CRF01_AE strains were independently introduced into the population of MSM in China in the early and mid-1990s. Our study elucidated unique features of dynamics and interrelationships of MSM epidemics in China.

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confidence: 99%

Reconstituting the Epidemic History of HIV Strain CRF01_AE among Men Who Have Sex with Men (MSM) in Liaoning, Northeastern China: Implications for the Expanding Epidemic among MSM in China

Han

et al. 2012

J Virol

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“…However, recent studies have reported the emergence and rapid increase of non-B subtypes in various populations globally (Cuevas et al, 2009;Liao et al, 2009;Hawke et al, 2013;Neogi et al, 2014;Beloukas et al, 2016;Nikolopoulos et al, 2016;Dennis et al, 2017), especially among men who have sex with men (MSM) in China (Zhang et al, 2015). CRF01_AE, CRF_BC and Subtype B/B' are most prevalent in Mainland China (Su et al, 2014), and CRF01_AE has recently replaced subtype B as the dominant circulating subtype among Chinese MSM (Zhang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…However, some studies also reported that the frequency of non-B subtypes has been increasing in Western Europe and North America (Thomson and Najera, 2007; UK Collaborative Group on HIV Drug Resistance, 2014), especially among MSM population of eight countries in North America, Western Europe and Australia (Sullivan et al, 2009). Recent studies of European HIV populations have reported that CRF01_AE strains have emerged in European MSM population, accounting for 11.2% in the United Kingdom (Fox et al, 2010) and 11.1% in Spain (Cuevas et al, 2009), among newly detected non-B strains. However, few studies have focused on the genetic links of HIV-1 CRF01_AE strains between countries or regions.…”

Section: Introductionmentioning

confidence: 99%

Cross-Continental Dispersal of Major HIV-1 CRF01_AE Clusters in China

Han

Zhao

et al. 2020

Front. Microbiol.

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Since the 1990s, several distinct clusters of human immunodeficiency virus-type 1 (HIV-1) CRF01_AE related to a large epidemic in China have been identified, but it is yet poorly understood whether its transmission has dispersed globally. We aimed to characterize and quantify the genetic relationship of HIV-1 CRF01_AEs circulating in China and other countries. Using representative sequences of Chinese clusters as queries, all relevant CRF01_AE pol sequences in two large databases (the Los Alamos HIV sequence database and the UK HIV Drug Resistance Database) were selected with the online basic local alignment search (BLAST) tool. Phylogenetic and phylogeographic analyses were then carried out to characterize possible linkage of CRF01_AE strains between China and the rest of the world. We identified that 269 strains isolated in other parts of the world were associated with five major Chinese CRF01_AE clusters. 80.7% were located within CN.01AE.HST/IDU-2, most of which were born in Southeast Asia. 17.8% were clustered with CN.01AE.MSM-4 and -5. Two distinct sub-clusters associated with Chinese men who have sex with men (MSM) emerged in HK-United Kingdom and Japan after 2000. Our analysis suggests that HIV-1 CRF01_AE strains related to viral transmission in China were initially brought to the United Kingdom or other countries during the 1990s by Asian immigrants or returning international tourists from Southeast Asia, and then after having circulated among MSM in China for several years, these Chinese strains dispersed outside again, possibly through MSM network. This study provided evidence of regional and global dispersal of Chinese CRF01_AE strains. It would also help understand the global landscape of HIV epidemic associated with CRF01_AE transmission and highlight the need for further international collaborative study in this field.

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“…6,7 The PR-RT segment was amplified from plasma RNA and sequenced as previously described. 8 The analyzed sequences (HXB2 nt positions 2253-3552) were aligned manually using BioEdit (http://www.mbio.ncsu.edu/BioEdit/BioEdit.html) and phylogenetic trees were constructed via maximum likelihood using TreeFinder, 9 applying the best-fit model of evolution, as determined under the Akaike information criterion by jModeltest, 10 with assessment of the reliability of tree topologies by bootstrapping with 100 replicates.…”

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confidence: 99%

Identification of a New HIV Type 1 Circulating BF Intersubtype Recombinant Form (CRF47_BF) in Spain

Fernández-García

Pérez-Álvarez

Cuevas

et al. 2010

AIDS Research and Human Retroviruses

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We report the identification of a new HIV-1 circulating recombinant form (CRF47_BF) derived from subtypes B and F. It was initially identified in protease-reverse transcriptase sequences from nine individuals from three separate regions of Spain who acquired HIV-1 infection via sexual contact. All nine sequences formed a strongly supported phylogenetic cluster, branching apart from all known CRFs, and in bootscan analyses were BF mosaics with two coincident breakpoints. Two epidemiologically unlinked viruses were sequenced in near full-length genomes, which exhibited identical mosaic structures, with 16 intersubtype breakpoints in a genome predominantly of subtype B. Subtype F segments of the new CRF failed to cluster with any of the near full-length genome subtype F sequences available in public databases. Recent dates of HIV-1 diagnoses and short genetic distances suggest a recent origin of this CRF. This is the tenth reported CRF_BF, the first apparently having originated outside of South America.

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Incidence of non-B subtypes of HIV-1 in Galicia, Spain: high frequency and diversity of HIV-1 among men who have sex with men

Cited by 17 publications

References 10 publications

Reconstituting the Epidemic History of HIV Strain CRF01_AE among Men Who Have Sex with Men (MSM) in Liaoning, Northeastern China: Implications for the Expanding Epidemic among MSM in China

Reconstituting the Epidemic History of HIV Strain CRF01_AE among Men Who Have Sex with Men (MSM) in Liaoning, Northeastern China: Implications for the Expanding Epidemic among MSM in China

Cross-Continental Dispersal of Major HIV-1 CRF01_AE Clusters in China

Identification of a New HIV Type 1 Circulating BF Intersubtype Recombinant Form (CRF47_BF) in Spain

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