Incidence of Multiple Pregnancy After in-Vitro Fertilisation and Embryo Transfer

Kerin, John F.; Quinn, Patrick G.; Kirby, Christine A.; Seamark, R.F.; Warnes, G. M.; Jeffrey, Regan; Matthews, C.A.; Cox, Leonie

doi:10.1016/s0140-6736(83)90569-x

Cited by 75 publications

(33 citation statements)

References 11 publications

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“…Of the 17 included cohort studies, four were prospective, 28–31 eight retrospectively reviewed clinic or database records, 32–39 and five used historical controls 40–44 …”

Section: Resultsmentioning

confidence: 99%

Single or multiple embryo transfer following in vitro fertilisation for improved neonatal outcome: A systematic review of the literature

Dare

Crowther

Dodd

et al. 2004

Aust NZ J Obst Gynaeco

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Information on neonatal and maternal outcomes following transfer of different numbers of embryos is limited. Transfer of one embryo does not alter the likelihood of a singleton pregnancy or birth when compared to transfer of two or more embryos. Transfer of one or two embryos decreases the risk of a multiple pregnancy, preterm birth and low birthweight. Further large, well-designed randomised trials are required to provide maternal and neonatal outcomes of relevance to a couple undergoing IVF.

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“…Of the 17 included cohort studies, four were prospective, 28–31 eight retrospectively reviewed clinic or database records, 32–39 and five used historical controls 40–44 …”

Section: Resultsmentioning

confidence: 99%

Single or multiple embryo transfer following in vitro fertilisation for improved neonatal outcome: A systematic review of the literature

Dare

Crowther

Dodd

et al. 2004

Aust NZ J Obst Gynaeco

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“…Limitations on the availability of pure porcine relaxin and the numbers of patients in the IVF programme did not allow the number of patients in the trial to be large enough to detect possible more subtle influences on singleton pregnancy. It has already been shown that multiple embryo transfer is likely to be more successful than single embryo transfer (17) and it is possible that the endometrium and ovary recognize the multiple stimulus of several embryos more readily than one. Four of the 6 ongoing pregnancies in the placebo group were multiple gestations.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Porcine Relaxin Vaginally Applied at Human Embryo Transfer in an In Vitro Fertilization Programme

MacLennan

Kerin

Kirby

et al. 1985

Aust NZ J Obst Gynaeco

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It has been suggested that the polypeptide hormone relaxin is an early pregnancy factor which facilitates implantation and pregnancy maintenance. To test this hypothesis a double blind randomized placebo controlled trial was conducted where 2 mg purified porcine relaxin or distilled water was given in a vaginal gel on the day of embryo transfer and again 3 days later in a human in vitro fertilization (IVF) programme. There were 96 patients in the randomized trial and 73 patients who were treated concurrently in the same IVF programme acted as a further control group. Of the 51 patients who received relaxin, 10 pregnancies were confirmed and 8 continued successfully. In the 45 patients treated with placebo 10 pregnancies were also confirmed and 6 continued successfully. Amongst the 73 patients concurrently treated outside the trial 14 achieved a pregnancy and 10 continued to term. Thus, porcine relaxin given in these circumstances in a human IVF programme did not appear to improve or interfere with the pregnancy rate. Possible factors that affected the implantation rates in this trial are discussed.

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“…After an endogenous surge or hCG injection, androstenedione concentrations fall to a mean of 68 ng/ml (Brailly et al, 1981), 95 ng/ml (Templeton, 1985) or 28 ng/ml (Edwards et al, 1980). In hyperstimulated women, concentrations after the post-ovulatory stimulus were clearly higher at 300 ng/ml (Carson et al, 1982) and 500 ng/ml (Kerin et al, 1985).…”

Section: Androstenedione and Testosteronementioning

confidence: 99%

The endocrine environment of the human oocyte

et al. 1988

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Incidence of Multiple Pregnancy After in-Vitro Fertilisation and Embryo Transfer

Cited by 75 publications

References 11 publications

Single or multiple embryo transfer following in vitro fertilisation for improved neonatal outcome: A systematic review of the literature

Single or multiple embryo transfer following in vitro fertilisation for improved neonatal outcome: A systematic review of the literature

The Effect of Porcine Relaxin Vaginally Applied at Human Embryo Transfer in an In Vitro Fertilization Programme

The endocrine environment of the human oocyte

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