Incidence of Mortality and Associated Factors Among Colorectal Cancer Patients at Oncology Units of Northwest Ethiopia: A Retrospective Cohort Study

Tiruneh, Yenework Mulu; Beshah, Debrework Tesgera; Wassie, Mulugeta

doi:10.2147/cmar.s349495

Cited by 4 publications

(2 citation statements)

References 44 publications

(39 reference statements)

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“…Limitations include the fairly small size of the study; data collection for the group with temporary ostomies was conducted by telephone; and that Swedish and Ethiopian patients were not directly comparable due to differences in age and comorbidities. The young age in the Ethiopian group is probably due to the many trauma patients in the EthioTemp group and generally younger age for colorectal cancer patients in Ethiopia 29 …”

Section: Discussionmentioning

confidence: 99%

Stoma‐related complications and quality‐of‐life assessment: A cross‐sectional study with patients from Ethiopia and Sweden

Eklöv,

Shiferaw,

Rosen

et al. 2024

World j. surg.

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BackgroundThe situation for patients with ostomy can be challenging, probably more in a resource‐constrained environment. Our objective was to evaluate quality of life (QoL) (using EQ5D‐5L) and stoma‐specific QoL (using Stoma QoL) in a high‐ and low‐income setting.MethodsIn this cross‐sectional study from the Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, and South General Hospital (SGH), Stockholm, patients with a permanent or temporary ostomy at TASH (EthioPerm), (EthioTemp), and patients with ostomy at SGH (SweSto) were included in October 2022–January 2023.ResultsPatients N = 66 were included in groups: EthioPerm N = 28, EthioTemp N = 17, and SweSto N = 21. In EthioTemp, 88% used homemade stoma bags. Although morbidity related to the nipple itself was similar in the groups, the overall score from Stoma QoL was significantly lower in EthioPerm, 48/100 than in SweSto, 74/100. Scores were significantly lower for pouch‐related problems and social interactions in Ethiopian patients. In EthioPerm, 71% of the patients worried that they were a burden to the people close to them compared to 14% in SweSto (p < 0.001). Leakage was over four times more common in EthioPerm than in SweSto. Mean overall EQ5D‐5L score was 18 percentage points lower than the national mean score in EthioPerm and 2 percentage points lower in SweSto.ConclusionQoL was more affected in the Ethiopian study participants than in the Swedish, even when commercial stoma bags were available. The largest problems were leakage, embarrassment with social interactions, and pouch‐related problems.Trial registrationNCT05970458 Clinicaltrials.gov, https://clinicaltrials.gov/study/NCT05970458?locStr=Ethiopia&country=Ethiopia&distance=50&cond=Stoma%20Ileostomy&rank=1.

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Section: Discussionmentioning

confidence: 99%

Stoma‐related complications and quality‐of‐life assessment: A cross‐sectional study with patients from Ethiopia and Sweden

Eklöv,

Shiferaw,

Rosen

et al. 2024

World j. surg.

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“…CRC was the second leading cause of cancer deaths (about 935,000 deaths) worldwide in 2020 2 . The global burden of CRC is expected to increase by 60% to more than 3.2 million new cases and 1.6 million deaths in 2040 3 .…”

Section: Introductionmentioning

confidence: 99%

Theoretical basis validation and oxidative stress markers for cancer prevention clinical trials of aspirin

Hamoya,

Tomono,

Miyamoto

et al. 2023

Sci Rep

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Aspirin, a nonsteroidal anti-inflammatory drug, has been proven effective in a clinical trial of carcinogenesis blockade. However, various modes of action have been reported for these effects. Thus, in this study, we aimed to present reasonable mode of actions as a proof of concept for human trials, especially trials for patients with familial adenomatous polyposis (FAP). Aspirin treatment at 1000 ppm inhibited intestinal tumorigenesis in FAP model Min mice. As a mode of action, aspirin regulated β-catenin signaling, inflammation, and oxidative stress both in vivo and in vitro. Furthermore, we examined novel markers predictive of aspirin treatment based on liquid biopsy. Here, we demonstrated that aspirin reduced the levels of reactive carbonyl species in the serum of Min mice. These data are expected to be of use for proof of concept of aspirin human trials and implied for the prediction of aspirin efficacy.

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Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Aynalem,

Adal,

Ayele

et al. 2024

BMC Cancer

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Introduction The incidence of colorectal cancer (CRC) has been increasing in Sub-Saharan countries, including Ethiopia. However, the real mortality rate for CRC patients in Ethiopia has not been established. Therefore, this systematic review and meta-analysis aimed to determine the overall mortality rate and identify predictors among CRC patients in Ethiopia. Methods PubMed, EMBASE, Web of Science, Scopus, Science Direct, and Google Scholar were searched to identify relevant articles. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. The quality of the included studies was assessed using the Newcastle-Ottawa Scale Critical Appraisal checklist. A random effect model was used to estimate the pooled mortality rate and adjusted hazard ratio (AHR). Publication bias was assessed using funnel plots and Egger’s regression test, while heterogeneity was evaluated through the Cochran Q test and I2 statistics. Results After reviewing 74 articles, only 7 studies met the criteria and were included in the analysis. The analysis revealed that the overall mortality rate among CRC patients in Ethiopia was 40.5% (95% confidence interval [CI]: 32.05, 48.87) while the survival rates at 1 year, 3 years, and 5 years were 82.3% (95% CI: 73.33, 91.31), 48.8% (95% CI: 43.35, 54.32), and 26.6% (95% CI: 21.26, 31.91) respectively. Subgroup analysis indicated that studies conducted after 2017 had higher mortality rates compared to those studied earlier (43.0% vs. 38.2%). Older age (AHR: 1.89, 95% CI: 1.27, 2.82); being married (AHR: 2.53, 95% CI: 1.79, 3.57); having comorbidities (AHR: 1.84, 95% CI: 1.45, 2.35); having high CEA levels (AHR: 2.06, CI: 1.35, 3.13); being in stage II (AHR: 4.13, 95% CI: 1.85, 9.22), III (AHR: 8.62, 95% CI: 3.88, 19.15), and IV (AHR: 8.06, CI: 2.89, 22.49) were the most important predictors. Conclusion In Ethiopia, the mortality rate among individuals diagnosed with CRC is high, with two out of five patients dying from this disease. Age, marital status, CEA level, comorbidities, and cancer stage were identified as predictors of mortality in CRC patients. Therefore, early detection and screening should be prioritized, particularly for older patients, those who are married, have comorbidities, elevated CEA levels, and advanced cancer stages.

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Incidence of Mortality and Associated Factors Among Colorectal Cancer Patients at Oncology Units of Northwest Ethiopia: A Retrospective Cohort Study

Cited by 4 publications

References 44 publications

Stoma‐related complications and quality‐of‐life assessment: A cross‐sectional study with patients from Ethiopia and Sweden

Stoma‐related complications and quality‐of‐life assessment: A cross‐sectional study with patients from Ethiopia and Sweden

Theoretical basis validation and oxidative stress markers for cancer prevention clinical trials of aspirin

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

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