Incidence of mitral valve prolapse in subjects with thoracic skeletal abnormalities—A prospective study

Udoshi, Mallikarjun; Shah, Anilkumar; Fisher, Vincent J.; Dolgin, Martin

doi:10.1016/0002-8703(79)90429-0

Cited by 85 publications

(31 citation statements)

References 37 publications

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“…Thoracic skeletal abnormalities such as straight thoracic spine and pectus excavatum are commonly associated with this syndrome. 35,36) The mitral valve undergoes differentiation between the thirty-fifth and forty-second days of fetal life, when the thoracic vertebra and thoracic cage are beginning chondrification and ossification. 37) Therefore, it has been postulated that primary MVP syndrome is a connective tissue disorder resulting from exposure to toxic agents during the early part of pregnancy.…”

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confidence: 99%

The Relationship Between Echocardiographic Features of Mitral Valve and Elastic Properties of Aortic Wall and Beighton Hypermobility Score in Patients With Mitral Valve Prolapse

et al. 2004

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SUMMARYThe present study was designed to investigate the incidence of benign joint hypermobility syndrome (BJHMS) in mitral valve prolapse (MVP) and the correlation between the echocardiographic features of the mitral valve and elastic properties of the aortic wall and Beighton hypermobility score (BHS) in patients with MVP and BJHMS.Fourty-six patients with nonrheumatic, uncomplicated, and isolated mitral anterior leaflet prolapse (7 men and 39 women, mean age; 26.1 ± 5.9) and 25 healthy subjects (3 men and 22 women, mean age, 25.4 ± 4.3) were studied. Patients were divided into two groups according to their BHS (group I, MVP+BJHMS; group II, MVP-BJHMS). Individuals with accompanying cardiac or systemic disease were excluded. Echocardiographic examination was performed in all subjects. The presence of BJHMS was evaluated according to Beighton's criteria.The incidence of BJHMS in patients with MVP was found to be significantly higher than that of controls (45.6%, (21/46) vs 12% (3/25), P < 0.0001). Group I (MVP + BJHMS) had significantly increased anterior mitral leaflet thickness (AMLT, 3.4 ± 0.4 vs 3.1 ± 0.3; P < 0.005), maximal leaflet displacement (MLD, 2.4 ± 0.4 vs 1.7 ± 0.4; P < 0.005), and degree of mitral regurgitation (DMR, 17.1 ± 7.2 vs 11.2 ± 4.4; P < 0.01) compared to group II. However, the index of aortic stiffness (IAOS) was found to be lower (17.6 ± 6.9 vs 23.9 ± 7.6; P < 0.005) and aortic distensibility (AOD) to be higher (0.0035 ± 0.007 vs 0.0024 ± 0.005; P < 0.005) in group I. There was a significant correlation between AMLT, MLD and DMR, and BHS (r = 0.57/P = 0.007, r = 0.55/P < 0.009, r = 0.51/P < 0.01, respectively). In addition, AOD correlated positively with BHS (r = 0.53/ P < 0.005), but the index of aortic stiffness correlated inversely with BHS (r = -0.49/P < 0.007).The incidence of BJHMS in patients with MVP was more frequent than the normal population and there was a significant correlation between the severity of BJHMS From the

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Section: )mentioning

confidence: 99%

The Relationship Between Echocardiographic Features of Mitral Valve and Elastic Properties of Aortic Wall and Beighton Hypermobility Score in Patients With Mitral Valve Prolapse

et al. 2004

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“…Close association of mitral valve prolapse syndrome with thoracic skeletal anomalies and connective tissue disorders is well known. In fact, mitral valve prolapse has been suggested to be a form of developmental connective tissue disorder (Salomon et al, 1975;Udoshi et al, 1979). This crosssectional survey demonstrated a relatively low prevalence of mitral valve prolapse compared with previous observations (Darsee et al, 1978;Markiewicz et al, 1976;Sbarbaro et al, 1979).…”

Section: Discussionmentioning

confidence: 53%

Prevalence of mitral valve prolapse in presumably healthy korean adults

Lee¹,

Sheikh²,

Lee³

1985

Clinical Cardiology

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Summary:This cross-sectional study on mitral valve prolapse (MVP) in Korean adults revealed a relatively low overall prevalence at 2.5% (5 of the 200 subjects). Three of 5 subjects with MVP were females and the majority (4 of 5 subjects) were under 30 years of age. All subjects with MVP had thoracic skeletal deformities (4 straight back syndrome and 1 pectus excavatum). All subjects with MVP did not have cardiac history and they were all asymptomatic except for one who had intermittent palpitation of mild degree.

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“…In addition to MVP, our patient had partial syndactyly of both hands which prevented radial flexion of the wrist. This has not been described before in large reviews of this syndrome (Devereux et al, 1976;Engel and Hickman, 1980;Gibney and Maurer, 1980;Hancock and Cohn, 1966;leresaty,1973, 1979Udoshi et al, 1979) .…”

Section: Discussionmentioning

confidence: 68%