Incidence of malignant tumors in U.S. children

106

The Manchester Children's Tumour Registry data for the period 1954-1977 have been analysed. The overall incidence of malignant disease in children aged 0-14 years in the north-west of England is estimated to be 100 per million person-years. The most common disease group is leukaemia, which forms about one third of the total number of cases. Among solid tumours, by far the most common presenting site is the central nervous system, representing nearly a quarter of all neoplasms. Wilms' tumour, neuroblastoma and soft-tissue sarcomas comprise approximately 5%, 6.5% and 6% respectively of the total. The tumours most frequently seen in adults (e.g. carcinoma of colon, lung and breast) are extremely rare in childhood. A significant excess of males was seen in acute lymphoid leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, medulloblastoma and hepatoblastoma. A female excess was found among germ-cell tumours. During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance.

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data

Birch¹,

Marsden²,

Swindell³

1980

106

“…The mean annual incidence of 25 per 106 children with newly diagnosed brain tumours is in agreement with incidence studies or cancer registry materials from the last 10 years (Doll et al, 1966;Cohen and Modan, 1968;Marsden and Steward, 1968;Bjelke, 1970;Doll et al, 1970;Percy et al, 1972;Stewart et al, 1973;Teppo et al, 1975;Young and Miller, 1975;Schoenberg et al, 1976;Heiskanen, 1977 material from the period in question (Doll et al, 1966;Doll et al, 1970;Teppo et al, 1975), the annual incidence rates in the present study are a little lower than in some other countries (Canada, Israel, New Zealand) but close to the rates for the other Scandinavian countries, England, Holland, Scotland, and the USA. Our study is retrospective, but the social system in Denmark ensures that sooner or later all children with symptoms of a brain tumour are admitted to hospital and reported to the Cancer Registry.…”

Section: Discussionsupporting

confidence: 81%

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Gjerris¹,

Harmsen²,

Klinken³

et al. 1978

Summary.-The total number of children under 15 years of age with intracranial tumours in Denmark during the years 1935-1959 was found to be 533. The average incidence was 21 new cases/106 children/year during the 25-year period in question, and 25/106 children/year during the first 17 years of Danish cancer registration. The sex ratio (290 boys to 243 girls) was not significantly different from that of the child population in Denmark. In 219 cases the tumour was located in the supratentorial and in 314 in the infratentorial space. 9300 of the tumours were histologically verified, with the following order of frequency for the most usual types: astrocytomas (all grades), medulloblastomas, ependymomas, and craniopharyngiomas. Follow-up was 1000%. For the 345 children who survived for more than one month after operation or diagnosis, 36% were alive after 15 years. 119 patients were alive in April 1974 and these were all observed between 15-40 years after diagnosis and operation. Of these 44 had tumours in the supratentorial and 75 in the infratentorial space. 660/" of the survivors with supratentorial and 9000 with infratentorial tumours led a normal life.Most of the survivors had had a cerebellar astrocytoma, a supratentorial astrocytoma, an apendymoma or oligodendroglioma, but other histological diagnoses were also represented, especially in the supratentorial group. The long-term prognosis was especially bad for children with brain-stem tumours, infratentorial ependymomas and medulloblastomas.

“…the incidence of childhood cancer throughout the world, and most of these are from cool or temperate areas of the northern hemisphere (Young & Miller, 1975;Ericsson et al, 1978;Teppo et al, 1975;Birch et al, 1980;Pastore et al, 1979). Data from most cancer registries about childhood cancer are not sufficiently detailed, and therefore of limited value.…”

mentioning

confidence: 99%

Incidence of childhood tumours in Queensland

McWhirter¹,

Bacon²

1981

Summary.-The incidence of childhood cancer in Queensland has been studied using the data of the population-based Queensland Childhood Malignancy Registry. During the 7-year period [1973][1974][1975][1976][1977][1978][1979]454 cases were registered, giving an annual agespecific incidence of 11 34/105 for the age group 0-14 years inclusive. There was a male/female ratio of 1-36. The commonest group of diseases was that of the leukaemias, followed by that of CNS tumours. The incidences of the various types of tumour in Queensland have been compared with those from other reported series. The incidence of leukaemia was midway between that of U.S. whites and that of Manchester, while the incidences of lymphoma and Wilms' tumour were much closer to those of the United States. Ewing's tumour was considerably commoner than osteosarcoma. THERE ARE FEW DETAILED REPORTS on