Incidence of Malignancies in HIV‐Infected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

Abstract

The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and non-ADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 person-years of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM.

Incidence of Non-AIDS-Defining Cancer in Antiretroviral Treatment-Naïve Subjects after Antiretroviral Treatment Initiation: An ACTG Longitudinal Linked Randomized Trials Analysis

“…Our results show an association between cigarette smoking and increased risk of cancer in HIV-infected patients, a factor not evaluated in other recent studies [8,11,27]. The association was independent of age, race, sex and CD4 levels, and was present even after the lung cancers were excluded from the analysis.…”

“…Other studies have also noted that the risk of NADCs may be related to CD4 counts [8,11,25,26,27]. In the FIRST study, recent CD4 counts were associated with the risk of non-AIDS diseases, but sample size limited the estimation of the risk for individual types of non-AIDS diseases [25].…”

“…A recent study suggested that use of potent ART, specifically nonnucleoside reverse transcriptase inhibitors (NNRTIs), may be associated with increased cancer risk [8]. Nadir and/or recent CD4+ T cell levels have been associated with the risk of NADC, although results have been varied [9,10,11]. A high prevalence of smoking and other lifestyle factors in the HIV-infected population have also been implicated [1]; however, there is a limited body of evidence to support these observations.…”

The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART

“…[1][2][3] These patients remain at increased risk of non-AIDS-related illnesses and mortality despite years of suppressive cART. [4][5][6] Clinical or genetic factors that may predict impaired CD4 T-cell recovery could potentially be used to identify patients who would benefit from earlier initiation of cART.…”

Neoplasias en pacientes con infección por VIH: Estudio descriptivo de 129 casos en el período 1993-2010

“…El recuento bajo de CD4 se ha asociado claramente a un mayor riesgo de desarrollo de NDS, sin estar clara la asociación con los NNDS, con estudios que sí la encuentran 46 y otros que no 47 . Parece que en el desarrollo de NNDS el valor pronóstico del nadir de CD4 es mucho mayor que la cifra de CD4 al diagnóstico del tumor 48 . Además, con los resultados del estudio SMART 49 , se sabe que la suspensión del TARGA conlleva un mayor riesgo de desarrollar NDS.…”