Incidence of locally advanced breast cancer in women presenting to a tertiary care center

Abstract

Background: Trends for incidence of breast cancer are on the rise in India. However, regional specific epidemiological data for North Coastal Andhra Pradesh are inadequate. The study aims to stress upon the trends of the incidence and burden of locally advanced breast cancer in the region.Methods: In a retrospective quantitative study, 310 in-patients of Department of General Surgery, King George Hospital diagnosed with breast cancer whose information is in the medical records covering the calendar period from May 2014 to May 2019 were studied.Results: The number of females being admitted as in-patients for treatment of breast cancer has increased from 11.2% to 13.6% in these five years. The overall result showed that the age of breast cancer patients ranged from 28-74 years, with a mean age of 49.12±10.942. The average duration of time lag to contact with health personnel was 3.6 months for all the cases included in our study. Stage III was the most common presentation constituting 55.01% patients of the series. Most common cause for late presentation was lack of awareness (64.5%) followed by emotional reasons and cultural barriers (31.9%).Conclusions: There is an urgent need for implementation of measures to ensure early presentation as prevention of LABC is much better than cure.

The Effect of Metformin When Combined With Neoadjuvant Chemotherapy in Breast Cancer Patients

“…When we used RCB classification (table 3(, we found that four patients (14.8%) and two patients (6.3%) in group (A) and (B) had CPR respectively with (P-value 0.39). Eleven patients (40.7%) in group (A) had the worst RCB class "class 3" in comparison to 22 patients (68.8%) in group (B) and the difference was statistically significant in favor of the group A "Metformin group" (p=0.031) figure (3). The RCB index mean value in group (A) was 2.7, while in group (B) was 3.3 with (P-value 0.053), also approaching significance in favor of the Metformin group.…”

“…According to US National Cancer Database and European CONCORD study, LABC represents 9.6% and 4% of breast cancer patients, respectively. However, this percent jump to 60% in developing and low-income countries [2][3][4][5] . The prognosis of LABC is as in early breast cancer, it depends on clinical stage, tumor grade, and expression of ER, PR, and HER-2 receptors.…”

Cost-effectiveness of Post-Mastectomy Radiotherapy (PMRT) for breast cancer in India: An economic modelling study

“…1 Most patients with breast cancer present at a locally advanced stage. 2 Modified radical mastectomy is the commonly performed surgery for patients with breast cancer in India, in view of advanced stage at presentation and limited resources in terms of surgical expertise, pathology, radiology and radiotherapy. 3 …”