Incidence of lobular carcinoma in bilateral breast cancer

Lewis, Thomas A.; Casey, J; Buerk, Charles A.; Cammack, Kirk V.

doi:10.1016/0002-9610(82)90540-2

Cited by 13 publications

(6 citation statements)

References 10 publications

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“…If having one breast cancer is a significant risk factor for developing a second, then the management of patients who have had a curative resection of one breast tumor possibly could lead to the diagnosis of the second at an earlier stage of the patient's disease when, hopefully, the tumor is more amenable to therapy. Certain histologic types of breast cancer have been recognized as having a high rate of bilateral tumors and already prompt specific management unique to those tumor types [3]. Lobular and tubular carcinomas were not a significant proportion of this study population, and therefore, our experience reflects primarily the more common histologic breast tumor types.…”

Section: Discussionmentioning

confidence: 94%

Bilateral breast carcinoma: Prospective evaluation of factors assisting diagnosis

Janus

McDermott

et al. 1986

J. Surg. Oncol.

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Bilateral primary breast cancers occur commonly enough to justify adoption of special pre- and post-initial therapy screening. A 13.2% incidence of bilateral breast carcinoma has been found in the breast cancer patients who presented to the Fox Chase Cancer Center with an operatively manageable primary in an arbitrarily defined 30-month period and who have been followed for at least 20 months thereafter. Of the 287 patients seen in those 30 months, 4.5% had synchronously detectable lesions. Xeroradiography is helpful in the initial and follow-up evaluation of the patient for detection of a second primary and may lead to the discovery of an earlier-stage lesion. A history of a family member having a breast cancer was shown to be significant, 26% and 24% for primary and secondary relatives, respectively, and warrant a special screening strategy. Recognition of these factors may lead to earlier detection of curable breast cancers.

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Section: Discussionmentioning

confidence: 94%

Bilateral breast carcinoma: Prospective evaluation of factors assisting diagnosis

Janus

McDermott

et al. 1986

J. Surg. Oncol.

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“…This association has previously been observed.11. 12 We interpret the finding of lobular carcinoma in situ on contralateral biopsy to be biologically important as a manifestation of the malignant potential of the glandular epithelium in these patients. In two patients treated for lobular carcinoma in situ during this period, coexisting infiltrating cancers were present within the resected breasts, one of ductal origin and one an infiltrating lobular carcinoma.…”

Section: Discussionmentioning

confidence: 95%

“…The contralateral breast biopsy was introduced by Urban et aL4 in an effort to detect these new cancers at an earlier, localized stage; they reported an incidence of 12.5% simultaneous breast cancer in the patients who underwent a biopsy of the second breast.…”

mentioning

confidence: 99%

Selective biopsy of the opposite breast

Pressman

1986

Cancer

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The bilaterality of breast cancer detected by performing a contralateral biopsy has been reported to be 14%. Since the majority of cancers detected were noninfiltrating, a mastectomy was not always performed because of either the advanced stage of the presenting carcinoma or the age of the patient. This study was undertaken to determine the yield of contralateral cancers in younger patients with a better prognosis. Patients younger than 65 years with clinical Stage I and I1 initial breast cancers were selected for biopsy of the opposite breast between September 1978 and December 1984. Of 651 consecutive patients treated for breast cancer, 610 had an initial breast cancer and 258 (42%) met the criteria. Forty-three contralateral primary breast cancers were detected, for an incidence of 16.7%. In 11 of these 43 patients there was suspicion that a malignancy might be present; these were all infiltrating carcinomas. In 32 patients a truly random biopsy was performed, and the yield was 14.2%. Four (12.5%) of these were infiltrating cancers, and 28 (87.5%) were in situ carcinomas. By selecting patients for biopsy of the opposite breast, a 16.7% incidence of cancers can be detected. Since these patients were younger than 65 years and have a good prognosis in terms of their initial breast cancer, biopsy of the opposite breast is a worthwhile procedure and should be performed with the hope of improving these patients' ultimate outcome. Cancer 51577-580, 1986. HE RISK of the development of a second breast cancer T is considerably greater than that of the initial ma-lignancy. In that quadrant of the breast where an infiltrating carcinoma is diagnosed, additional infiltrating and in situ malignancy commonly coexist. Gallager and Mar-tin have demonstrated the frequent multicentric origin of breast cancer.' Since the breasts are paired organs, when this malignant potential becomes clinically evident in the opposite breast depends on the duration of follow-up of the patient. It has been accepted practice that, after the initial mas-tectomy, frequent breast palpation and periodic mam-mography are adequate for detecting a second breast cancer. However, the detection of localized breast cancer by physical examination is known to be difficult and unreliable ,* and the limitations of mammography are recog-n i ~ e d. ~ The second breast cancer is frequently found in a more advanced stage than the one for which the patient was originally treated, and may determine the ultimate fate of the patient. The contralateral breast biopsy was introduced by Urban et aL4 in an effort to detect these new cancers at an earlier, localized stage; they reported

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“…Family history is consistently reported and younger age at diagnosis of the initial tumor has been cited (1,5,6,13–18). Lobular histology of the initial tumor has been inconsistently associated with an increased risk (10,16,18–20). In contrast, therapy (particularly with tamoxifen) of the initial tumor appears to reduce the risk of CBC development (20–22).…”

Section: Discussionmentioning

confidence: 99%

“…Aside from the findings of similarities between the initial tumor and CBC, such as histologic subtype and hormone receptor status (17–26), relatively little has been published describing factors associated with the clinical presentation of CBC, and specifically regarding changes in presentation over time. Most publications report a collected experience with CBC over a number of years, usually in a single center or tumor registry.…”

mentioning

confidence: 99%

Contralateral Breast Cancer: Factors Associated with Stage and Size at Presentation

2004

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Few reports have evaluated factors associated with the stage at presentation of contralateral breast cancer and whether contralateral cancer presentation has changed in recent years, during which increased screening and enhanced adjuvant therapy of the initial tumor has been introduced. Patients with initial cancers staged 0-IIIB diagnosed between 1980 and 1999 who subsequently developed contralateral breast cancer were evaluated for stage, primary tumor size and histologic features, patient age and year of diagnosis, synchronous or metachronous presentation, and time from initial tumor to diagnosis of contralateral breast cancer. Tumor presentation was compared with contemporaneously diagnosed unilateral breast cancer patients. A total of 171 patients were diagnosed with contralateral breast cancer; 161 cases if lobular carcinoma in situ for either the initial or the contralateral tumor were excluded. Contralateral tumors were of significantly smaller size and of earlier stage than initial tumors. Contralateral cancers demonstrated earlier stage distributions with more recent year of diagnosis; initial tumors in contralateral patients did not. Earlier stage at presentation of contralateral tumors was associated in a multivariate model with more recent year of contralateral tumor diagnosis and earlier stage at presentation of the initial tumor; contralateral tumor size was associated with the size of the initial tumor. More recently diagnosed contralateral breast cancers are presenting with earlier stages of disease. The stages of initial tumors in these patients have not undergone such an improvement. Initial tumor size and stage is strongly associated with contralateral breast cancer size and stage; this association is independent of the year of diagnosis. Increased compliance with screening might be expected to improve both initial tumor stage and tumor size presentations in contralateral tumor patients, as well as the presentation of contralateral cancers.

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Incidence of lobular carcinoma in bilateral breast cancer

Cited by 13 publications

References 10 publications

Bilateral breast carcinoma: Prospective evaluation of factors assisting diagnosis

Bilateral breast carcinoma: Prospective evaluation of factors assisting diagnosis

Selective biopsy of the opposite breast

Contralateral Breast Cancer: Factors Associated with Stage and Size at Presentation

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