Incidence of lipoid pneumonia in a survey of 389 chronically ill patients

Volk, Bruno W.; Nathanson, Louis; Losner, Samuel; Slade, Walter R.; Jacobi, Mendel

doi:10.1016/0002-9343(51)90276-8

Cited by 49 publications

(16 citation statements)

References 11 publications

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“…a dense lesion with a pseudotumoral appearance, associated with fibrosis of the pulmonary parenchyma. The long duration of exposure (mean of 9.5 yrs) concurs with other results in the literature [2,7,10]. One case occurred after administration of an oily substance for only 1 month.…”

Section: Discussionsupporting

confidence: 90%

“…Several similar examples, in which the duration of the exposure ranged 1-3 months, were reported in the analysis of ROUFFY et al [7]. The predisposing factors identified have been reported in several papers [2,10,12,13,15,16], but with no indication of their frequency. These predisposing factors are not obligatory for oil to penetrate into the airways, as they were absent in 25% of the present cases.…”

Section: Discussionmentioning

confidence: 85%

“…However, in 1970, GENEREUX [6] reported a radiological description, which, although not providing precise data concerning the frequency of the various images, corresponded to the impression given by the present series. The author did not mention the ground glass opacities, but this aspect was reported by VOLK et al [10]. The density of parenchymal lesions on CT scan can be measured during the examination, but the lesion would have to be homogeneous, as the presence of air inside the lesions would give falsely negative measurements.…”

Section: Discussionmentioning

confidence: 99%

“…The predominance of this aetiology is frequently reported in the literature but used to be less marked, and, in some cases, was of similar importance to nasal instillation of oily products for chronic rhinopharyngeal diseases [2,7,10,11]. The oil responsible was almost always a mineral oil (paraffin or vaseline).…”

Section: Discussionmentioning

confidence: 99%

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Exogenous lipid pneumonia: a retrospective multicentre study of 44 cases in France

Gondouin¹,

Ranfaing²,

Brun³

et al. 1996

European Respiratory Journal

206

215

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A nationwide retrospective study of exogenous lipid pneumonia (ELP) was carried out to update the data on this disease, with emphasis on thoracic computed tomography (CT) scan and bronchoalveolar lavage (BAL) findings.The inclusion criteria were: 1) presence of abnormal imaging features compatible with the diagnosis of ELP; 2) presence of intrapulmonary lipids; and 3) exogenous origin of the lipid pneumonia.Forty four cases were included (20 males and 24 females; mean age 62±11 yrs), of which four were occupational (chronic inhalation of cutting mist or oily vapour in an industrial environment). Thirty of the 40 nonoccupational cases were related to aspiration of liquid paraffin used for the treatment of constipation. A condition possibly favouring oil aspiration or inhalation was present in 34 patients (77%), most commonly gastro-oesophageal reflux (n=20) and neurological or psychiatric illness (n=14). Fever (39%), weight loss (34%), cough (64%), dyspnoea (50%) and crepitations (45%) were the most frequent symptoms. BAL was performed in 39 cases: 23% had a lymphocytic alveolitis; 14% neutrophilic alveolitis; and 31% a mixed alveolitis (lymphocytic and neutrophilic). Alveolar consolidations (57%), ground glass opacities (39%), and alveolar nodules (23%) were the most common radiological abnormalities. The changes were bilateral (79%), predominant in the posterior and lower zones of the lobes concerned (74%), hypodense (71%), and spared the subpleural zones (52%). In 13 cases, hypodensity was retrospectively established on CT scan by the presence of a "positive angiogram". This sign may be of diagnostic value when the density measurement is either not possible or not reliable.In conclusion, this study provides an update of the clinical, biological and radiological profile of exogenous lipid pneumonia and, in particular, confirms the diagnostic benefit of computed tomography scan, which revealed bilateral and hypodense changes in a large majority of cases.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Exogenous lipid pneumonia: a retrospective multicentre study of 44 cases in France

Gondouin¹,

Ranfaing²,

Brun³

et al. 1996

European Respiratory Journal

206

215

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“…The 1950s was an innovative decade, with the description of such varied and important drug-induced patterns as: lipoid pneumonia [9]; allergic pneumonia from para-aminosalicylic acid [10]; other anti-tuberculosis agents [11]; or nitrofurantoin [12]; the lupus erythematosus syndrome induced by hydralazine [13]; acute allergic pulmonary oedema from salicylates [14]; mediastinal lymphadenopathy or lymphoma from anticonvulsants [15]; and a severe diffuse pattern of organizing pneumonia, very reminiscent of what is now called diffuse bronchiolitis obliterans organizing pneumonia (BOOP), in patients exposed to hexamethonium [16].…”

mentioning

confidence: 99%

Respiratory disease induced by drugs

Camus¹

1997

Eur Respir J

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which averages 100 clinical articles per year ( fig. 1). Collectively, of approximately 2,650 clinical articles published so far, 32% are related to chemotherapeutic agents: bleomycin (226 papers); busulphan (58); cyclophosphamide (75); methotrexate (129); and nitrosoureas (46). Adverse pulmonary effects from: amiodarone (214 articles); ergolines (54); gold salts (133); minocycline (35); nitrofurantoin (135); nonsteroidal anti-inflammatory drugs (NSAIDs) (58); and sulphasalazine (22) point to all these drugs as being common offenders of the respiratory system, in addition to angiotensin-converting enzyme (ACE) inhibitors. On this basis, a brief historical perspective on DIRD is warranted.The first notice of adverse effects of drugs on the respiratory system dates back to the years 1920-1930, when it was realized that aspirin could induce severe asthma attacks and even death [2]. In the 1940s, the then newer antibiotic drugs were associated with allergic pneumonia with or without eosinophilia or angiitis [3,4], and gold was linked to the development of interstitial lung disease [5], although most of the literature on "gold lung" was published later [6][7][8].The The 1960-1969 decade was dominated by an overwhelming number of reports on nitrofurantoin lung. In addition, a worrisome picture of medication-induced pulmonary hypertension emerged, and an epidemic of this devastating illness in young females was ascribed to the appetite-suppressant, aminorex, which was withdrawn from the market [17]. For the first time, it became clear that one drug could induce more than one pattern of respiratory reactions. In the case of nitrofurantoin, these patterns included: acute allergic pneumonia, with or without eosinophilia in the blood [18]; subacute/chronic interstitial pneumonia, with or without a desquamative or eosinophilic pattern at histology [19][20][21]

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Exogenous Lipoid Pneumonia

Spickard¹

1994

Arch Intern Med

133

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Exogenous lipoid pneumonia is an uncommon condition resulting from aspirating or inhaling fatlike material, such as mineral oil found in laxatives and various aerosolized industrial materials. These substances elicit a foreign body reaction and proliferative fibrosis in the lung. Because symptoms are absent or nonspecific and the roentgenographic findings simulate other diseases, exogenous lipoid pneumonia is often unrecognized. Yet, appropriate historical inquiries and simple laboratory tests can lead to the correct diagnosis, removal of the offending agent, and, potentially, improvement in lung function before serious complications develop.

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Incidence of lipoid pneumonia in a survey of 389 chronically ill patients

Cited by 49 publications

References 11 publications

Exogenous lipid pneumonia: a retrospective multicentre study of 44 cases in France

Exogenous lipid pneumonia: a retrospective multicentre study of 44 cases in France

Respiratory disease induced by drugs

Exogenous Lipoid Pneumonia

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