Incidence of lethal adverse drug reactions in the comprehensive hospital drug monitoring, a 20-year survey, 1974-1993, based on the data of Berne/St. Gallen

Zoppi, M.; Braunschweig, Suzanne; Kuenzi, Urs Peter; Maibach, R; Hoigné, R

doi:10.1007/s002280000158

Cited by 33 publications

(37 citation statements)

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“…Drug interactions with benzimidazoles are increasingly reported [1,2,[47][48][49][50]. However, it has been noted that the 50% inhibitory concentration (IC 50 ) values of PPIs in inhibiting P-gp observed in vitro are higher than their expected intraluminal (intestinal) and plasma concentrations obtained after oral dosing in humans, making a drug-drug interaction at these levels unlikely.…”

Section: Inhibitors (Competitive Noncompetitive)mentioning

confidence: 99%

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Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)

et al. 2007

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Key Words. P-glycoprotein • Drug interaction • Complementary and alternative medicine • CAM • Pharmacokinetics Pharmacodynamics LEARNING OBJECTIVESAfter completing this course, the reader will be able to:1. Identify important sources of variability in drug exposure caused by drug interactions mediated by P-glycoprotein.2. Describe how unwanted drug-drug interactions may lead to unexpected serious toxicity or undertreatment.3. Prevent these interactions by individualizing pharmacotherapy; this means selecting noninteracting drugs or adapting the dose of (the) interacting drug(s).Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTThe importance of P-glycoprotein (P-gp) in drug-drug interactions is increasingly being identified. P-gp has been reported to affect the pharmacokinetics of numerous structurally and pharmacologically diverse substrate drugs. Furthermore, genetic variability in the multidrug resistance 1 gene influences absorption and tissue distribution of drugs transported. Inhibition or induction of P-gp by coadministered drugs or food as well as herbal constituents may result in pharmacokinetic interactions leading to unexpected toxicities or undertreatment. On the other hand, modulation of P-gp expression and/or activity may be a useful strategy to improve the pharmacological profile of anticancer P-gp substrate drugs. In recent years, the use of complementary and alternative medicine (CAM), like herbs, food, and vitamins, by cancer patients has increased significantly. CAM use substantially increases the risk for interactions with anticancer drugs, especially because of the narrow therapeutic window of these compounds. However, for most CAMs, it is unknown whether they affect metabolizing enzymes and/or drug transporter activity. Clinically relevant interactions are reported between St John's wort or grapefruit juice and anticancer as well as nonanticancer drugs. CAM-drug interactions could explain, at least in part, the large interindividual variation in efficacy and toxicity associated with drug therapy in both cancer and noncancer patients.

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Section: Inhibitors (Competitive Noncompetitive)mentioning

confidence: 99%

“…Up to 10% of all admissions in general hospitals are caused by improper use of drugs and combinations of drugs, resulting in potentially severe drug-drug interactions [1,2]. Adverse drug reactions can especially be severe when these interactions involve cytotoxic anticancer agents [3,4].…”

Section: Introductionmentioning

confidence: 99%

Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)

et al. 2007

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“…Previous studies have reported different factors that predispose patients to ADRs [3][4][5][6]. In some of these studies female gender was considered an important risk factor for ADRs [3,4,6].…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with adverse drug reactions in hospitalised children: international multicentre study

Rashed

Wong

Cranswick

et al. 2011

Eur J Clin Pharmacol

104

117

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“…Literature had shown that female gender was considered as the major risk factor for occurrence of adverse drug reaction. 7,8,9,10 Along with this, some other risk factors like age, multiple drug regimen, intercurrent diseases, comorbidity, history of adverse drug reactions to the drug class, concurrent interactive drugs were also considered. 11 But there is diversity in the effect of predisposing factors to the development of adverse drug reactions.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Predisposing Factors Associated with Suspected Adverse Drug Reactions of Hospitalized Patients

Mudigubba¹,

Rajashekarachari²,

Dahiya³

2018

JYP

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Objectives: To study the incidence and to evaluate the risk factors of suspected adverse drug reactions developed in the hospitalized patients of various departments and to assess the causality and severity of adverse drug reactions (ADRs). Methods: It was a retrospective-prospective study conducted in a tertiary care hospital for a period of two years two months, with a specific predefined criterion. A total of 254 subjects with ADRs were identified during the period of study for which 1:1 ratio of subjects with non-ADRs were taken. Subjects of all age groups and of either sex were enrolled. Risk factors included subjects' age group, gender, polypharmacy, comorbidity, intercurrent diseases and concurrent interactive drugs. Statistical analysis used: Multiple logistic regression analysis was performed to find the association of risk factors with adverse drug reactions. Results: The incidence of suspected adverse drug reactions in hospitalized patients was13% (254/1952, 95%CI). Polypharmacy was the most significant predictor of adverse drug reactions (OR=55.952; 95%CI). Elderly population with multidrug therapy had developed the higher rate of ADRs. Cephalosporin's 27.6%, fluoroquinolones 15.5%, penicillamines 12.1%, anti-hypertensive 8.7%, NSAIDs 8.3% were more frequently implicated. Risk factors for suspected ADRs were: age (more than 60 years) (OR=1.033: 95% CI), gender [Male (OR=55.952; 95% CI)], comorbidity (OR=1.008; 95% CI), intercurrent diseases (OR=19.27; 95% CI). Conclusion: Polypharmacy, history of ADR, concurrent interactive drugs and inter current disease were the significant risk factors of adverse drug reactions. The elderly population was the vulnerable age group for ADRs. Multidrug therapy and comorbidity resulted in higher risk of ADRs in an older population. The Higher rate of suspected ADRs were probable and very less severe. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. Mudigubba et al.: Evaluation of Predisposing Factors Associated with Suspected Adverse Drug Reactions of Hospitalized PatientsJournal of Young Pharmacists, Vol 10, Issue 2, Apr-Jun, 2018203 were interviewed about the previous medical and medication history, co-morbid conditions, lifestyle and diet which were also updated inpatient case sheet for future reference. Retrospectively case data was collected from the reported documents which were stored in drug information centre and control data from the medical record database of the hospital. The patients who had no ADR were selected as controls. The severity of suspected adverse effects was assessed as mild, moderate and severe by using the specific standard scale called Hart wig and Siegel's scale, and the Naranjo`s algorithm was used to assess the causal relationship between the suspected drug and ADR. For evalu...

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Incidence of lethal adverse drug reactions in the comprehensive hospital drug monitoring, a 20-year survey, 1974-1993, based on the data of Berne/St. Gallen

Abstract: The patients with a lethal outcome were presented under the eight pharmacologic-therapeutic classes of drugs and the classification proposed by NS Irey. This is based on long histopathologic experience and helps to identify preventable risks.

Cited by 33 publications

References 0 publications

Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)

Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)

Risk factors associated with adverse drug reactions in hospitalised children: international multicentre study

Evaluation of Predisposing Factors Associated with Suspected Adverse Drug Reactions of Hospitalized Patients

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