Incidence of Late-onset Ocular Hypertension Following Uncomplicated Pars Plana Vitrectomy in Pseudophakic Eyes

Toyokawa, Noriko; Kimura, Hideya; Matsumura, Miyo; Kuroda, Shinichiro

doi:10.1016/j.ajo.2015.01.010

Cited by 25 publications

(20 citation statements)

References 27 publications

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“…Wu et al [14] reported an OR of 2.5 for pseudophic eyes to develop ocular hypertension, and this finding was attributed to oxidative stress from the high oxygen concentration on the trabecular meshwork [21,22]. However, the incidence of ocular hypertension was found to be higher in our study than in the studies using PPV only [14,22]. Furthermore, we found that hypertension occurred mostly 6 weeks after surgery (late onset).…”

Section: Discussioncontrasting

confidence: 63%

Incidence and Risk Factors of Ocular Hypertension following Pars Plana Vitrectomy and Silicone Oil Injection

et al. 2018

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Purpose: To evaluate the risk factors for elevated intraocular pressure (IOP) after pars plana vitrectomy (PPV) with silicone oil injection (SOI). Procedures: This prospective interventional study included 254 consecutive eyes receiving PPV with SOI. Results: Elevated IOP developed in 48% of the eyes postoperatively. The onset of IOP elevation was early (≤1 week) in 61.5% of the eyes, intermediate (1–6 weeks) in 28.7%, and late (> 6 weeks) in 9.8%. The incidence of IOP elevation was higher with primary uncomplicated rhegmatogenous retinal detachment than with tractional detachment (p = 0.01). Pseudophakia, high myopia, and high preoperative IOP were found to have higher incidences of ocular hypertension, whereas diabetic patients had a lower incidence. Conclusion: IOP elevation is a common complication following silicone oil (SO) tamponade. Risk factors for ocular hypertension development are pseudophakia, high myopia, high preoperative IOP, and low-viscosity SO.

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Section: Discussioncontrasting

confidence: 63%

Incidence and Risk Factors of Ocular Hypertension following Pars Plana Vitrectomy and Silicone Oil Injection

et al. 2018

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“…[9] [10] [11] Chang first reported the development and worsening of open angle glaucoma (OAG) during a long-term period following vitrectomy compared to the fellow eyes. [9] He hypothesized that an increase in the partial pressure of oxygen in the vitreous cavity after vitrectomy can cause oxidative stress on the trabecular meshwork resulting in an IOP elevation which is exacerbated by lens extraction.…”

Section: Introductionmentioning

confidence: 99%

“…Koreen et al reported that lens extraction was a strong risk factor for the development of late-onset OAG after uncomplicated PPV [10], and Toyokawa et al also reported an IOP elevation after vitrectomy in pseudophakic eyes. [11]…”

Section: Introductionmentioning

confidence: 99%

Long-Term Changes in Intraocular Pressure after Vitrectomy for Rhegmatogenous Retinal Detachment, Epi-Retinal Membrane, or Macular Hole

2016

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PurposeTo determine the long-term changes in the intraocular pressure (IOP) following vitrectomy for rhegmatogenous retinal detachment (RRD), epiretinal membrane (ERM), and macular hole (MH), and to investigate the relationship between the retinal disease and the incidence of late-onset IOP elevation.MethodsThis was a retrospective, observational, comparative study. We reviewed the medical records of 54 eyes of 54 RRD patients, 117 eyes of 117 ERM patients, and 75 eyes of 75 MH patients who underwent 20-, 23- or 25-gauge vitrectomy. The IOPs before surgery and 1, 3, 6, and 12 months following vitrectomy, and also at the final visit (average, 23.95 months) were evaluated. We defined a significant increase in the IOP as an increase of ≥4 mmHg from the preoperative IOP, and this increase was taken to be a ‘death’ event for the Kaplan-Meier survival analyses.ResultsThe mean follow-up period was not significantly different among the groups. The mean IOP at 3 (P = 0.001) and 12 (P = 0.011) months following the vitrectomy and at the final visit (P = 0.002) were significantly higher than that before the vitrectomy in the RRD group. The mean IOP in the RRD group was significant higher than that in the ERM group at 1 (P = 0.005), 3 (P = 0.009), and 12 (P = 0.013) months following vitrectomy, and at the final visit (P = 0.032). Kaplan-Meier survival analyses showed that the RRD group had a significantly higher risk of an IOP increase following vitrectomy than the other groups (P<0.001 by log-rank test). Multivariate logistic regression analyses showed that a preoperative diagnosis of RRD was the only risk factor that was significantly associated with a postoperative IOP elevation after excluding eyes with a low preoperative IOP (odds ratio, 3.208; P = 0.003).ConclusionsA late-onset IOP elevation following vitrectomy was observed only in eyes that underwent RRD surgery. The elevation was probably caused by the specific characteristics and surgical procedures of RRD. Clinicians should pay more attention to the IOP elevation for long times after vitrectomy especially in eyes with RRD.

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“…Intra-ocular pressure (IOP) was measured with Goldmann applanation tonometry (Haag-Streit, Switzerland). Delayed ocular hypertension was defined as IOP≥24 mmHg on two separate postoperative visits occurring at least 2 months after PPV (Wu et al 2014;Toyokawa et al 2015). The results were presented as mean AE standard deviation (range).…”

Section: Referencesmentioning

confidence: 99%

“…Editor, P ars plana vitrectomy (PPV) has increasingly been used to treat rhegmatogenous retinal detachment (RRD). However, PPV potentially provokes ocular hypertension and/or glaucoma in the long term (Chang 2006;Wu et al 2014;Toyokawa et al 2015). The hypothesized mechanism is postoperative intra-ocular hyperoxygenation causing oxidative damage to trabecular meshwork and decreased aqueous humour outflow capacity (Chang 2006;Siegfried et al 2010).…”

mentioning

confidence: 99%

The occurrence of delayed ocular hypertension and glaucoma after pars plana vitrectomy for rhegmatogenous retinal detachment

Ivastinović

Smiddy

Wackernagel

et al. 2016

Acta Ophthalmologica

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Incidence of Late-onset Ocular Hypertension Following Uncomplicated Pars Plana Vitrectomy in Pseudophakic Eyes

Cited by 25 publications

References 27 publications

Incidence and Risk Factors of Ocular Hypertension following Pars Plana Vitrectomy and Silicone Oil Injection

Incidence and Risk Factors of Ocular Hypertension following Pars Plana Vitrectomy and Silicone Oil Injection

Long-Term Changes in Intraocular Pressure after Vitrectomy for Rhegmatogenous Retinal Detachment, Epi-Retinal Membrane, or Macular Hole

The occurrence of delayed ocular hypertension and glaucoma after pars plana vitrectomy for rhegmatogenous retinal detachment

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