Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors

Missmer, Stacey A.; Hankinson, Susan E.; Spiegelman, Donna; Barbieri, Robert L.; Marshall, Lynn M.; Hunter, David J.

doi:10.1093/aje/kwh275

Cited by 494 publications

(401 citation statements)

References 40 publications

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“…The point estimates of an association between increased BMI and endometriosis, suggestive of a decreased risk of endometriosis among obese women, were similar to those found by Missmer et al 35 in the US Nurses' Health Study. The US Nurses' Health Study, however, contained fewer endometriosis cases and in that study, the association between obesity and endometriosis failed to reach statistical significance.…”

Section: Discussionsupporting

confidence: 85%

“…This is in line with the findings of other studies. 27,35 One possible explanation for this finding lies in the relationship between smoking and increased anti-inflammatory cytokines. 36 Since much of the pain associated with endometriosis is probably mediated through an inflammatory response to the ectopic endometrial-like tissue, it is possible that smoking suppresses endometriosis-related pain symptoms, which in turn reduces the likelihood of endometriosis diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1

Ballard

Seaman

Vries

et al. 2008

BJOG

327

232

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Objective To determine the value of patient-reported symptoms in diagnosing endometriosis.Design A national case-control study.Setting Data from the UK General Practice Research Database for years 1992-2001.Sample A total of 5540 women aged 15-55 years, diagnosed with endometriosis, each matched to four controls without endometriosis.Methods Data were analysed to determine whether specific symptoms were highly indicative of endometriosis. Odds ratios for these symptoms were derived by conditional logistic regression analysis. . Women with endometriosis were also found to consult the doctor more frequently than the controls and were twice as likely to have time off work.Conclusions Specific symptoms and frequent medical consultation are associated with endometriosis and appear useful in the diagnosis. Endometriosis may coexist with or be misdiagnosed as pelvic inflammatory disease or IBS.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1

Ballard

Seaman

Vries

et al. 2008

BJOG

327

232

View full text Add to dashboard Cite

show abstract

“…Studies have shown that African-American women have lower incidence rates than Caucasian Americans, while Asian Americans seem to have higher rates than Caucasian women [18][19][20][21]. For Hispanic women however, comparative data are lacking, although this group now represents the fastest growing minority population in the United States [22].…”

Section: Introductionmentioning

confidence: 99%

Self‐reported prevalence of endometriosis and its symptoms among Puerto Rican women

Flores

Abreu

Abac

et al. 2007

Intl J Gynecology & Obste

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Objective-To determine the prevalence of endometriosis and its symptoms in a Puerto Rican cohort, and to describe the menstrual, obstetric, and clinical profiles of the women.Methods-A self-administered questionnaire was given to 1285 Puerto Rican women. Categorical variables were compared using χ 2 analysis or Fisher exact test.Results-There were 57 self-reported cases of endometriosis (48 surgically confirmed) among 1193 valid questionnaires, for a point prevalence of 4.0%. A diagnosis of endometriosis was significantly associated with dysmenorrhea, dyspareunia, and chronic pelvic pain, but not with menstrual cycle characteristics. Undiagnosed women commonly reported signs and symptoms of endometriosis.Conclusions-The estimated prevalence of endometriosis in Puerto Rico is 4.0%, comparable to what has been reported in other populations. Endometriosis symptoms were common in the population surveyed, indicating the need for increased awareness and development of public health policies leading to early diagnosis and appropriate management.

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“…1,2 It is defined as the presence of endometriumlike tissue in sites outside the uterine cavity, primarily on the pelvic peritoneum and ovaries. 3 Signs and symptoms include chronic pelvic pain, dysmenorrhea, and reduced fertility.…”

mentioning

confidence: 99%

Association Between Endometriosis and Hypercholesterolemia or Hypertension

Rich‐Edwards

Rimm

et al. 2017

Hypertension

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Abstract-An altered hormonal or chronic systemic inflammatory milieu characterizing endometriosis may result in a higher risk of hypercholesterolemia and hypertension. Conversely, elevated low-density lipoprotein in hypercholesterolemia and chronic systemic inflammation resulting from hypertension may increase the risk of endometriosis. We assessed the association of laparoscopically confirmed endometriosis with hypercholesterolemia and hypertension in a large prospective cohort study. In 1989, 116 430 registered female nurses aged 25 to 42 completed the baseline questionnaire and were followed for 20 years. Multivariable Cox proportional hazards models were applied. In 1989, there were 4244 women with laparoscopically confirmed endometriosis and 91 554 women without. After adjusting for demographic, anthropometric, family history, reproductive, dietary, and lifestyle risk factors prospectively, comparing women with laparoscopically confirmed endometriosis to women without, the relative risks were 1.25 (95% confidence interval, 1.21-1.30) for development of hypercholesterolemia and 1.14 (95% confidence interval, 1.09-1.18) for hypertension. Conversely, the relative risks of developing laparoscopically confirmed endometriosis were 1.22 (95% confidence interval, 1.15-1.31) comparing women with hypercholesterolemia to women without and 1.29 (95% confidence interval, 1.18-1.41) comparing women with hypertension to women without. The strength of associations of laparoscopically confirmed endometriosis with hypercholesterolemia or hypertension was strongest among women aged ≤40 and weakened as age increased (P values for interaction <0.001). We observed that ≈45% of the associations between endometriosis and hypercholesterolemia and hypertension could be accounted for by treatment factors after endometriosis diagnosis, including greater frequency of hysterectomy/oophorectomy and earlier age for this surgery. In this large cohort study, laparoscopically confirmed endometriosis was prospectively associated with increased risk of hypercholesterolemia and hypertension. Conversely, hypercholesterolemia and hypertension were prospectively associated with higher risk of laparoscopically confirmed endometriosis. process, which may be contributing to blood pressure elevation. 23 Hence the chronic systemic inflammation in endometriosis may predispose women with endometriosis to a higher risk of hypertension.In sum, women with endometriosis may have higher risk of hypercholesterolemia or hypertension, and women with hypertension or hypercholesterolemia may have a higher risk of endometriosis. We examined these hypotheses in the NHSII (Nurses' Health Study II), an ongoing prospective cohort study. Methods Study PopulationThe NHSII is a prospective cohort study with 116 430 registered female nurses who were 25 to 42 and resided in 14 of the United States at enrollment in 1989. At baseline, participants completed a detailed questionnaire and every 2 years thereafter completed follow-up questionnaires on the incidence of disease out...

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Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors

Cited by 494 publications

References 40 publications

Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1

Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1

Self‐reported prevalence of endometriosis and its symptoms among Puerto Rican women

Association Between Endometriosis and Hypercholesterolemia or Hypertension

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