Incidence of juvenile thyrotoxicosis in Madras, 1959–1964

Annamalai, Al.; Shreekumar, S.; Vellayan, Pr.

doi:10.1007/bf02756496

Cited by 2 publications

(1 citation statement)

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“…FcrO values obtained using CNDO/force calculations are found to differ only by about 1.6 x 10' N m-' (24). Hence, it is felt that the value of F,,, reported in the present work for acetic acid is more reasonable.…”

Section: Discussionsupporting

confidence: 40%

Force field of acetic acid: use of CNDO/force calculations

Annamalai¹,

Singh²

1983

Can. J. Chem.

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The redundancy-free internal valence force field of monomeric acetic acid is evaluated using CNDO/force calculations and least-squares refinement. The initial force field is set up by taking the interaction and bending force constants from CNDO force field and transferring the stretching force constants from the force fields of chemically related molecules. Vibrational frequencies of monomeric CH3COOH, CH3COOD, CD3COOH, and CD3COOD are used to refine the force constants. The experimental force field thus obtained is found to be reasonable when compared to the force fields of related molecules as well as on the basis of the frequency fits and potential energy distributions.

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Section: Discussionsupporting

confidence: 40%

Force field of acetic acid: use of CNDO/force calculations

Annamalai¹,

Singh²

1983

Can. J. Chem.

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Hyperthyroidism in children

Mokhashi

Desai

2000

Indian J Pediatr

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This study was done to characterize the clinical features, laboratory parameters and response to therapy and outcome of childhood hyperthyroidism. The evaluation included history, examination, laboratory investigations: serum T3, T4, TSH, free T3, free T4 by RIA or immunochemiluminescence (IC), antithyroid antibodies by standard techniques, bone age (BA) by Greulich and Pyle's method, clinical and laboratory response to treatment, and follow-up of 15 children with hyperthyroidism seen in past eight years. Age of onset, presentation, nature and duration of symptoms, family history, anthropometry and signs of hyperthyroidism were recorded. There were 10 girls and 5 boys (2:1). Three families had a history of thyroid disorders. Mean ages of onset and presentation were 8.25 +/- 3.4 and 9.27 +/- 3.2 years respectively. Clinical features included weight loss, heat intolerance and sweating, diarrhoea, behavioral problems, ophthalmopathy and tachycardia. BA was advanced. Serum T3 (mean = 4.29 +/- 1.77 ng/mL), T4 (18.75 +/- 5.64 micrograms/dL), FT3 (7.11 +/- 4.58 pg/mL) and FT4 (2.93 +/- 0.29 ng/mL) were markedly elevated. TSH was suppressed. Anti-microsomal antibodies (AMA) and anti-thyroglobulin antibodies (ATG) were positive in five. They were started on standard treatment with carbimazole 0.5-0.7 mg kg-1. Clinical and biochemical euthyroidism was achieved within 2.5 to 6 months in all, after which the drug was tapered, however, they required treatment for 2 years to 7.5 years. Four children were retreated for relapse and are now euthyroid and off treatment. Childhood hyperthyroidism requires long term treatment and careful monitoring. This study shows a remission rate of 67%.

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Incidence of juvenile thyrotoxicosis in Madras, 1959–1964

Cited by 2 publications

References 10 publications

Force field of acetic acid: use of CNDO/force calculations

Force field of acetic acid: use of CNDO/force calculations

Hyperthyroidism in children

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