Incidence of Intussusception in Bamako, Mali, Before and After the Introduction of Rotavirus Vaccine

Roose, Anna; Keita, Adama Mamby; Tapia, Milagritos D.; Sow, Samba O.; Mast, T. Christopher; Kotloff, Karen L.

doi:10.1093/jpids/piac044

Cited by 2 publications

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References 10 publications

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“…Although RV1 and RV5 were both found to be associated with a slightly elevated risk of intussusception within 1-7 days after vaccination, [12][13][14] To date, the incidence rate of intussusception for children aged <1 year after introduction of the RV vaccine has been evaluated in several countries (see Table 3). [20][21][22][23] Similar to the findings of the present study, a decreased incidence of intussusception after RV vaccine introduction was reported in Taiwan (82.2-68.7 per 100 000 infants from the pre-to post-vaccine era) and in Korea (241.7-177.3 per 100 000 infants from the pre-to post-vaccine era). 20,21 By contrast, the incidence of intussusception did not change significantly…”

Section: Discussionsupporting

confidence: 89%

“… 20–23 Similar to the findings of the present study, a decreased incidence of intussusception after RV vaccine introduction was reported in Taiwan (82.2–68.7 per 100 000 infants from the pre‐ to post‐vaccine era) and in Korea (241.7–177.3 per 100 000 infants from the pre‐ to post‐vaccine era) 20,21 . By contrast, the incidence of intussusception did not change significantly following RV vaccine introduction in Canada or in Mali 22,23 . The reported RV vaccination rate during the study period was approximately 50% in both Japan and Taiwan, whereas this rate was over 80% in Mali; thus, it is difficult to compare the differences in intussusception incidence rates because of the large differences in RV vaccination rates 24 .…”

Section: Discussionsupporting

confidence: 87%

“…following RV vaccine introduction in Canada or in Mali. 22,23 The reported RV vaccination rate during the study period was approximately 50% in both Japan and Taiwan, whereas this rate was over 80% in Mali; thus, it is difficult to compare the differences in intussusception incidence rates because of the large differences in RV vaccination rates. 24 Notably, the baseline (pre-RV vaccination) intussusception incidence was higher in East Asian countries, which may have contributed to the observed decrease in intussusception incidence after the introduction of RV vaccination.…”

Section: Ta B L E 2 Clinical Characteristics Of Intussusception Cases...mentioning

confidence: 99%

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Characteristics of intussusception among children in Hokkaido, Japan, during the pre‐ and post‐rotavirus vaccine eras (2007–2016)

et al. 2023

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Aim: To analyse the epidemiology of intussusception in Hokkaido Prefecture, Japan during a 10-year period spanning the introduction of the rotavirus (RV) vaccine (2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016).Methods: Using a standard questionnaire, a retrospective surveillance was conducted across 17 hospitals with paediatric beds in Hokkaido Prefecture. We compared the data between the pre-vaccine era (2007-2011) and post-vaccine era (2012-2016).Results: In total, 208 and 110 intussusception cases were in the pre-and post-vaccine eras, respectively. A significant reduction of the intussusception incidence in children aged <1 year was observed from the pre-to the post-vaccine era (102.4-56.5 per 100 000 infants; incidence rate ratio, 0.55; p = 0.004). There was a relatively highpositive RV antigen detection rate (29.4%, 5/17) during the RV epidemic period in Japan (March-May) in the pre-vaccine era. None of the intussusception cases in the 31 patients with a history of RV vaccination occurred within 1 month after the administration of an RV vaccine dose. Conclusions:The incidence of intussusception in children aged <1 year decreased significantly after RV vaccine introduction in Japan. Another survey is needed to determine how the incidence of intussusception has changed further since the introduction of routine RV vaccination in 2020.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Section: Ta B L E 2 Clinical Characteristics Of Intussusception Cases...mentioning

confidence: 99%

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Characteristics of intussusception among children in Hokkaido, Japan, during the pre‐ and post‐rotavirus vaccine eras (2007–2016)

et al. 2023

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“…Whether differences in factors such as genetics, diet or environment could explain this increased risk remains unclear. However, the differences in the frates of ISN by ethnicity could possibly be explained by low socioeconomic status [ 72 ], difference in access to health care or lack of accessibility to medical treatment [ 73 ], health care-seeking behavior [ 74 ] or lack of awareness among parents when their child presents with symptoms of ISN leading them to seek medical attention [ 75 ]. ISN classically presents in an infant or toddler with sudden onset of intermittent, severe and progressive abdominal pain, accompanied by inconsolable crying often with vomiting, palpable sausage-shaped abdominal mass, red currant jelly stools, anorexia, dehydration, irritability, abdominal tenderness, lethargy and pallor [ 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Intussusception and COVID-19 in Children: A Systematic Review and Meta-Analysis

et al. 2022

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Background: Intussusception (ISN) post-COVID-19 infection in children is rare but can occur. SARS-CoV-2 may play a role in the pathogenesis of ISN and trigger immune activation and mesenteric adenitis, which predispose peristaltic activity to “telescope” a proximal bowel segment into the distal bowel lumen. Objectives: To estimate the prevalence of SARS-CoV-2 infection in ISN children and analyze the demographic parameters, clinical characteristics and treatment outcomes in ISN pediatric patients with COVID-19 illness. Methods: We performed this systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies reporting on the incidence of ISN post-SARS-CoV-2 infection in children, published from 1 December 2019 until 1 October 2022, in PROQUEST, MEDLINE, EMBASE, PUBMED, CINAHL, WILEY ONLINE LIBRARY, SCOPUS and NATURE, with a restriction to articles available in the English language, were included. Results: Of the 169 papers that were identified, 34 articles were included in the systematic review and meta-analysis (28 case report, 5 cohort and 1 case-series studies). Studies involving 64 ISN patients with confirmed COVID-19 (all patients were children) were analyzed. The overall pooled proportions of the ISN patients who had PCR-confirmed SARS-CoV-2 infection was 0.06% (95% CI 0.03 to 0.09, n = 1790, four studies, I2 0%, p = 0.64), while 0.07% (95% CI 0.03 to 0.12, n = 1552, three studies, I2 0%, p = 0.47) had success to ISN pneumatic, hydrostatic and surgical reduction treatment and 0.04% (95% CI 0.00 to 0.09, n = 923, two studies, I2 0%, p = 0.97) had failure to ISN pneumatic, hydrostatic and surgical reduction treatment. The median patient age ranged from 1 to 132 months across studies, and most of the patients were in the 1–12 month age group (n = 32, 50%), p = 0.001. The majority of the patients were male (n = 41, 64.1%, p = 0.000) and belonged to White (Caucasian) (n = 25, 39.1%), Hispanic (n = 13, 20.3%) and Asian (n = 5, 7.8%) ethnicity, p = 0.000. The reported ISN classifications by location were mostly ileocolic (n = 35, 54.7%), and few children experienced ileo-ileal ISN (n = 4, 6.2%), p = 0.001. The most common symptoms from ISN were vomiting (n = 36, 56.2%), abdominal pain (n = 29, 45.3%), red currant jelly stools (n = 25, 39.1%) and blood in stool (n = 15, 23.4%). Half of the patients never had any medical comorbidities (n = 32, 50%), p = 0.036. The approaches and treatments commonly used to manage ISN included surgical reduction of the ISN (n = 17, 26.6%), pneumatic reduction of the ISN (n = 13, 20.2%), antibiotics (n = 12, 18.7%), hydrostatic reduction of the ISN (n = 11, 17.2%), laparotomy (n = 10, 15.6%), intravenous fluids (n = 8, 12.5%) and surgical resection (n = 5, 7.8%), p = 0.051. ISN was recurrent in two cases only (n = 2, 3.1%). The patients experienced failure to pneumatic (n = 7, 10.9%), hydrostatic (n = 6, 9.4%) and surgical (n = 1, 1.5%) ISN treatment, p = 0.002. The odds ratios of death were significantly higher in patients with a female gender (OR 1.13, 95% CI 0.31–0.79, p = 0.045), Asian ethnicity (OR 0.38, 95% CI 0.28–0.48, p < 0.001), failure to pneumatic or surgical ISN reduction treatment (OR 0.11, 95% CI 0.05–0.21, p = 0.036), admission to ICU (OR 0.71, 95% CI 0.83–1.18, p = 0.03), intubation and placement of mechanical ventilation (OR 0.68, 95% CI 0.51–1.41, p = 0.01) or suffering from ARDS (OR 0.88, 95% CI 0.93–1.88, p = 0.01) compared to those who survived. Conclusion: Children with SARS-CoV-2 infection are at low risk to develop ISN. A female gender, Asian ethnicity, failure to ISN reduction treatment (pneumatic or surgical), admission to ICU, mechanical ventilation and suffering from ARDS were significantly associated with death following ISN in pediatric COVID-19 patients.

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Incidence of Intussusception in Bamako, Mali, Before and After the Introduction of Rotavirus Vaccine

Cited by 2 publications

References 10 publications

Characteristics of intussusception among children in Hokkaido, Japan, during the pre‐ and post‐rotavirus vaccine eras (2007–2016)

Characteristics of intussusception among children in Hokkaido, Japan, during the pre‐ and post‐rotavirus vaccine eras (2007–2016)

Intussusception and COVID-19 in Children: A Systematic Review and Meta-Analysis

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