Incidence of intervertebral disk degeneration–related diseases and associated mortality rates in dogs

Bergknut, Niklas; Egenvall, Agneta; Hagman, Ragnvi; Gustås, Pia; Hazewinkel, H.A.W.; Meij, Björn P.; Lagerstedt, Anne-Sofie

doi:10.2460/javma.240.11.1300

Cited by 127 publications

(155 citation statements)

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“…Necas [8] indicated recurrence at the level of 14.59%, which is comparable with our results. The age of surgically treated dogs in our case was lower compared with previous studies [2,4,8,9], which may be associated with large percentage of chondrodystrophic dogs, for which the incidence age is lower. There is no single effective therapy to definitively cure SCI.…”

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confidence: 50%

“…Despite decades of research to identify the new therapeutics, there has been only limited progress toward the beneficial findings. Thoracolumbar intervertebral disk herniation is the most common naturally occurring spinal disease in dogs and results in compressive and contusive SCI [2,7,10]. The most common treatment for SCI is early stabilization of the spinal column followed by surgical decompression and stabilization and minimizing secondary changes [6].…”

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confidence: 99%

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Surgical treatment of spinal cord compression in client owned dogs with different grades of neurological dysfunction

Kuricova¹,

Ledecký²,

Lipták³

2016

Korean Journal of Veterinary Research

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: Our retrospective study reports the clinical findings and population characteristics of 81 surgically treated dogs for spinal cord compression. We compared the outcome of dogs with different grades of neurological dysfunction due to spinal cord compression and focused on the long-term outcome of surgical treatment, for which there are only a few recent records. We recorded a 13.6% recurrence, regardless of the degree of dysfunction. However, the degree of dysfunction negatively affected the recovery length.

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confidence: 50%

mentioning

confidence: 99%

Surgical treatment of spinal cord compression in client owned dogs with different grades of neurological dysfunction

Kuricova¹,

Ledecký²,

Lipták³

2016

Korean Journal of Veterinary Research

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“…CD breeds are characterized by a disturbed endochondral ossification, primarily in the diaphyses of the long bones, resulting in disproportionally short extremities, compared to the NCD dogs who have normal bodily constitutions (Hansen, 1952). These two dog types are dissimilar with regards to age of onset, prevalence and spinal location of IVD degeneration and IVD-related diseases (Hansen, 1952, Bergknut et al, 2012a, Priester, 1976.…”

Section: Introductionmentioning

confidence: 99%

“…However IVD degeneration is also highly associated with diseases like cervical and thoracolumbar IVD herniation, DLSS and CSM (Hansen, 1952, Meij and Bergknut, 2010, Burbidge, 1994, Bergknut et al, 2012a, da Costa et al, 2006. All these diseases involve IVD compression of neural tissue, which may lead to clinical signs of disease like gait abnormalities, postural deficits, pain, paresis, paralysis and lameness (Kranenburg et al, 2013, Brisson, 2010, Burbidge, 1994, Sharp, 2005.…”

Section: Function Of the Intervertebral Discmentioning

confidence: 99%

“…Degeneration of the IVD can be part of the normal aging process and degenerated IVDs are common incidental findings in clinically healthy dogs (Brisson, 2010, Hansen, 1952, da Costa et al, 2006. However, IVD degeneration is also highly associated with diseases like cervical and thoracolumbar IVD herniation, degenerative lumbosacral stenosis (DLSS) and cervical spondylomyelopathy (CSM) (Hansen, 1952, Meij and Bergknut, 2010, Burbidge, 1994, Bergknut et al, 2012a, da Costa et al, 2006.…”

Section: Introductionmentioning

confidence: 99%

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The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs

et al. 2017

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The myth of fibroid degeneration in the canine intervertebral disc -A histopathological comparison of disc degeneration in chondrodystrophic and nonchondrodystrophic dogs Myten om fibroid degeneration i hundens intervertebraldiskerEn histopatologisk jämförelse av diskdegeneration mellan chondrodystrofa och icke chondrodystrofa hundar Tove Hansen Supervisor: Niklas Bergknut, Department of Clinical Sciences Examiner: Ragnvi Hagman, Department of Clinical Sciences Degree Project in Veterinary Medicine SUMMARYIn the 1950's, the veterinary pathologist, Hans-Jörgen Hansen noticed several dissimilarities between so called chondrodystrophic and non-chondrodystrophic dog breeds regarding intervertebral disc degeneration and related diseases. Chondrodystrophic breeds are characterized by disproportionally short extremities due to disturbances in the endochondral ossification whereas non-chondrodystrophic breeds have normal bodily constitutions. The two breed types often differ regarding age of onset of disease, spinal location and severity of clinical signs. He also noted different histopathological patterns during the course of degeneration, foremost in the centre of the intervertebral disc, the nucleus pulposus. Due to this, he named the degenerative processes chondroid metamorphosis and fibroid metamorphosis in chondrodystrophic and non-chondrodystrophic breeds respectively. In general, chondroid metamorphosis refers to the replacement of the original cell type (the notochordal cell) with chondrocyte-like cells, whereas the fibroid metamorphosis refers to replacement of these cells with fibrocyte-like cells. This distinction has since then been an accepted distinction between the two breed types. However, more recent studies indicate that the histopathological patterns are more similar in the two breed types than previously described, and that the chondroid metamorphosis might be the degenerative process taking place in both breed types.In this study the histopathological appearances of 42 intervertebral discs from 16 chondrodystrophic and 17 non-chondrodystrophic dogs in early stage intervertebral disc degeneration were examined. After midsagittal transection of the spines, the intervertebral discs were graded macroscopically between one and three on a five-grade scale (the Thompson grading scheme). Subsequently, each intervertebral disc was individually fixated in formalin and decalcified in EDTA. After decalcification, the intervertebral discs were embedded in paraffin, sliced with a microtome and stained with Hematoxilin and Eosin and Alcian Blue/Picrosirius Red. The histological samples were thereafter graded according to a histological grading scheme (the Boos grading scheme) after which the histological scores were compared between chondrodystrophic and non-chondrodystrophic dogs.The results showed that there was a significant difference in total histological scores between chondrodystrophic and non-chondrodystrophic dogs in the two lowest macroscopical grades of degeneration. Chondrodystrophic dogs had a highe...

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History, Neurologic Examination, and Neuroanatomic Localization for Spinal Cord and Nerve Root Disease

Thomas¹,

Risio²

2014

Advances in Intervertebral Disc Disease in Dogs and Cats

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Incidence of intervertebral disk degeneration–related diseases and associated mortality rates in dogs

Cited by 127 publications

References 31 publications

Surgical treatment of spinal cord compression in client owned dogs with different grades of neurological dysfunction

Surgical treatment of spinal cord compression in client owned dogs with different grades of neurological dysfunction

The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs

History, Neurologic Examination, and Neuroanatomic Localization for Spinal Cord and Nerve Root Disease

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