Incidence of Idiopathic Normal-Pressure Hydrocephalus in Northern Spain

Martín-Láez, Rubén; Caballero-Arzapalo, Hugo; Román, Natalia Valle-San; López-Menéndez, Luis Ángel; Arango-Lasprilla, Juan Carlos; Vázquez-Barquero, Alfonso

doi:10.1016/j.wneu.2015.10.069

Cited by 47 publications

(22 citation statements)

References 40 publications

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“…Individuals with asymptomatic ventriculomegaly tended to be older (76.0 ± 5.6) and of male gender (70.8%). Although ventriculomegaly is common in both AD and NPH, the male predominance has been observed in NPH epidemiological study [20] , [21] , whereas gender predominance in AD is uncertain [22] , [23] even with female predominance is reported in AD studies [24] , [25] . Hence, our findings suggested that male cognitively intact elders with ventriculomegaly concord more with the early spectrum of iNPH although this needs to be confirmed in future longitudinal studies.…”

Section: Discussionmentioning

confidence: 90%

Characterizing biomarker features of cognitively normal individuals with ventriculomegaly

et al. 2017

Alz & Dem Diag Ass & Dis Mo

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Introduction The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear. Methods We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group. Neuropsychological, imaging, and fluid biomarker profiles between the two groups were then compared using regression models. Results A total of 96 (22.5%) individuals who had ventriculomegaly performed worse on the cognitive tests; showed smaller hippocampal volume but larger caudate, cingulate, and paracentral gyrus volumes; and displayed lower positron emission tomography [ 18 F]fluorodeoxyglucose standardized uptake value ratio but higher amyloid burden represented by higher [ 18 F]florbetapir standardized uptake value ratio and lower cerebrospinal fluid amyloid β 1–42 levels compared to those without ventriculomegaly. Discussion Asymptomatic ventriculomegaly might be an early imaging signature of preclinical Alzheimer's disease and/or normal pressure hydrocephalus.

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Section: Discussionmentioning

confidence: 90%

Characterizing biomarker features of cognitively normal individuals with ventriculomegaly

et al. 2017

Alz & Dem Diag Ass & Dis Mo

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“…Only 5 NPH studies provided relevant incidence figures ranging from 1.1 to 5.5 newly affected individuals per 100,000 persons. 8,47,51,55 Despite the high heterogeneity among the 4 studies, a meta-regression analysis was not possible due to the few studies in this group. An adequately powered, population-based estimate of the incidence of non-NPH adult hydrocephalus was not identified in this review.…”

Section: Adult Hydrocephalusmentioning

confidence: 99%

Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis

Dewan

Rattani

Mekary

et al. 2019

Journal of Neurosurgery

206

173

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OBJECTIVE Hydrocephalus is one of the most common brain disorders, yet a reliable assessment of the global burden of disease is lacking. The authors sought a reliable estimate of the prevalence and annual incidence of hydrocephalus worldwide. METHODS The authors performed a systematic literature review and meta-analysis to estimate the incidence of congenital hydrocephalus by WHO region and World Bank income level using the MEDLINE/PubMed and Cochrane Database of Systematic Reviews databases. A global estimate of pediatric hydrocephalus was obtained by adding acquired forms of childhood hydrocephalus to the baseline congenital figures using neural tube defect (NTD) registry data and known proportions of posthemorrhagic and postinfectious cases. Adult forms of hydrocephalus were also examined qualitatively. RESULTS Seventy-eight articles were included from the systematic review, representative of all WHO regions and each income level. The pooled incidence of congenital hydrocephalus was highest in Africa and Latin America (145 and 316 per 100,000 births, respectively) and lowest in the United States/Canada (68 per 100,000 births) (p for interaction < 0.1). The incidence was higher in low- and middle-income countries (123 per 100,000 births; 95% CI 98-152 births) than in high-income countries (79 per 100,000 births; 95% CI 68-90 births) (p for interaction < 0.01). While likely representing an underestimate, this model predicts that each year, nearly 400,000 new cases of pediatric hydrocephalus will develop worldwide. The greatest burden of disease falls on the African, Latin American, and Southeast Asian regions, accounting for three-quarters of the total volume of new cases. The high crude birth rate, greater proportion of patients with postinfectious etiology, and higher incidence of NTDs all contribute to a case volume in low- and middle-income countries that outweighs that in high-income countries by more than 20-fold. Global estimates of adult and other forms of acquired hydrocephalus are lacking. CONCLUSIONS For the first time in a global model, the annual incidence of pediatric hydrocephalus is estimated. Low- and middle-income countries incur the greatest burden of disease, particularly those within the African and Latin American regions. Reliable incidence and burden figures for adult forms of hydrocephalus are absent in the literature and warrant specific investigation. A global effort to address hydrocephalus in regions with the greatest demand is imperative to reduce disease incidence, morbidity, mortality, and disparities of access to treatment.

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“…Idiopathic normal pressure hydrocephalus (iNPH) has been recognised as a disease of the elderly since it was first described by Hakim in 1965 [7] with a reported prevalence of Previously presented, in part, at the Society of British Neurological Surgeons Conference, April 2012 and The 7th meeting of the International Society for Hydrocephalus and CSF Disorders conference, September 2014 0.1-1.4% in persons over the age of 65 [2,17,27] and 0.2% in persons over 70 [11]. This disease is typically suspected in patients with ventriculomegaly and some combination of gait disturbance, dementia and urinary incontinence [24].…”

Section: Introductionmentioning

confidence: 99%