Incidence of Herpes Zoster and Persistent Post-Zoster Pain in Adults With or Without Diabetes in the United States

Abstract

We assessed association between diabetes and herpes zoster (HZ) and persistent post-zoster pain (PPZP) in adults. Among 51 million enrollees [~88 million person-years at risk], individuals with diabetes had 45% and 18% higher adjusted risk of HZ and odds of PPZP, respectively.

Herpes zoster infection after an uncomplicated cataract surgery: A case report

“…But our patient had no any immunodeficient condition except diabetes mellitus, similar with those reports. In a study, it has been described that the incidence of HZ among individuals with diabetes was higher than among those without (6). So, the presence of the diabetes in our patient may be considered as a risk factor for occurrence of the HZ infection.…”

Herpes Zoster Infection as a Presentation for Hidden Diabetes Mellitus

“…There are inconclusive results regarding the role of severe immunosuppression as a risk factor for PHN which can be seen in about 10% -50% of patients with HZ, especially in diabetic individuals [2,[11][12]15]. The risk of PHN increases with increasing age (particularly over the age of 50) and is more significant in persons with severe pain at the onset of HZ or a severe rash with a large number of lesions [2][3]12].…”

Diabetes as a risk factor for herpes zoster in adults: A synthetic literature review

“…Of the 16 studies that investigated the magnitude of the association between HZ and diabetes (Table 1), three were conducted in Asia [5,23,24], five in Europe [25][26][27][28][29], four in the USA [30,31,18,32], two in Israel [33,34], one in Australia [35] and one in Canada [36]. Administrative claims or electronic medical record databases were used in all but one study [29].…”

“…The diagnosis of diabetes and HZ was based in general on the international ICD-9 and ICD-10 CM diagnosis system. The risk of HZ was significantly higher in patients with diabetes as compared to controls in 11 studies out of 16 [5,18,23,24,26,29,30,32,33,34,36] (Table 1). However, the magnitude of risk associated to diabetes varied widely, ranging from 1.06 (95%CI: 1.03-1.09) in a population-based case-control study carried out in the UK [27] to 2.38 (95%CI: 2.04-2.78) in the population-based retrospective cohort study carried out in Japan [23].…”