Incidence of Herpes Simplex Virus Keratitis in France

Labétoulle, Marc; Auquier, P.; Conrad, H.R.; Crochard, Anne; Daniloski, M.; Bouée, S.; Hasnaoui, Abdelkader El; Colin, Joseph

doi:10.1016/j.ophtha.2004.11.052

Cited by 168 publications

(128 citation statements)

References 21 publications

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“…This rate represents an increase of more than 50% compared with previously reported HSV keratitis rates in the general population (0.031%). 43 This trend complements existing data suggesting a relationship between excimer laser procedures and HSV keratitis. 7 Post-LASIK HSV keratitis has been reported in patients with and without a history of herpetic disease.…”

Section: Discussionsupporting

confidence: 81%

Infectious and noninfectious keratitis after laser in situ keratomileusis

Moshirfar¹,

Welling²,

Feiz³

et al. 2007

Journal of Cataract and Refractive Surgery

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The occurrence of post-LASIK keratitis was 2.66%, with DLK being the most common diagnosis overall. The occurrence of noninfectious keratitis (2.34%) was 7.5 times greater than the occurrence of infectious keratitis (0.31%). Adenoviral keratitis had the best visual outcomes overall, with all 18 patients achieving 20/20 BSCVA. In contrast, all 5 eyes with HSV keratitis lost 1 or 2 lines of BSCVA. Excluding adenoviral keratitis, infectious etiologies had significantly worse visual outcomes than noninfectious etiologies at the 20/40 and 20/20 levels (P = .0013 and P<.001, respectively).

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Section: Discussionsupporting

confidence: 81%

Infectious and noninfectious keratitis after laser in situ keratomileusis

Moshirfar¹,

Welling²,

Feiz³

et al. 2007

Journal of Cataract and Refractive Surgery

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“…4 This represents an increase of more than 50% of the HSV keratitis rate in the general population (0.031%). 9 The trend complements existing data suggesting a relationship between excimer laser procedures and HSV keratitis. Twelve cases of reactivation have been reported, and it is evident that it may occur even in the absence of a previous history of herpetic disease.…”

Section: Discussionsupporting

confidence: 75%

Reactivated herpetic keratitis following laser in situ keratomileusis

Jain

Pineda

2009

Journal of Cataract and Refractive Surgery

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A 40-year-old woman presented with an unusual form of corneal herpetic reactivation 5 weeks after laser in situ keratomileusis. The cornea showed diffuse edema and a stromal ring infiltrate (disciform in appearance). Oral antiviral and topical steroids in tapered dosages were administered. The infiltrate disappeared within 6 weeks. Progressive improvement was also seen in all the parameters on Pentacam scans, including the pachymetry, keratometry readings, and elevation on the anterior float. Herpetic reactivation may occur in many forms after excimer laser ablation. Timely diagnosis and management is crucial to maintain good structural and visual outcomes. Pentacam analysis may serve as a useful adjunct in following the progression of herpetic reactivation cases.

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“…However, HSV-1 may lead to recurrent labial lesions in 15 to 45% of the adult population (18), encephalitis in one per 500,000 people per year (65), and corneal keratitis with an annual incidence of 30 cases per 100,000 people (30). The genome is a linear ϳ152-kb DNA molecule that is organized into two covalently linked segments: a long (L; 82% of the genome) and a short (S; 18% of the genome) fragment.…”

mentioning

confidence: 99%

Structural Variability of the Herpes Simplex Virus 1 Genome In Vitro and In Vivo

Mahiet

Ergani

Huot

et al. 2012

J Virol

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dHerpes simplex virus 1 (HSV-1) is a human pathogen that leads to recurrent facial-oral lesions. Its 152-kb genome is organized in two covalently linked segments, each composed of a unique sequence flanked by inverted repeats. Replication of the HSV-1 genome produces concatemeric molecules in which homologous recombination events occur between the inverted repeats. This mechanism leads to four genome isomers (termed P, IS, IL, and ILS) that differ in the relative orientations of their unique fragments. Molecular combing analysis was performed on DNA extracted from viral particles and BSR, Vero, COS-7, and Neuro-2a cells infected with either strain SC16 or KOS of HSV-1, as well as from tissues of experimentally infected mice. Using fluorescence hybridization, isomers were repeatedly detected and distinguished and were accompanied by a large proportion of noncanonical forms (40%). In both cell and viral-particle extracts, the distributions of the four isomers were statistically equivalent, except for strain KOS grown in Vero and Neuro-2a cells, in which P and IS isomers were significantly overrepresented. In infected cell extracts, concatemeric molecules as long as 10 genome equivalents were detected, among which, strikingly, the isomer distributions were equivalent, suggesting that any such imbalance may occur during encapsidation. In vivo, for strain KOS-infected trigeminal ganglia, an unbalanced distribution distinct from the one in vitro was observed, along with a considerable proportion of noncanonical assortment.

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Incidence of Herpes Simplex Virus Keratitis in France

Cited by 168 publications

References 21 publications

Infectious and noninfectious keratitis after laser in situ keratomileusis

Infectious and noninfectious keratitis after laser in situ keratomileusis

Reactivated herpetic keratitis following laser in situ keratomileusis

Structural Variability of the Herpes Simplex Virus 1 Genome In Vitro and In Vivo

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