Incidence of hepatitis induced by non-steroidal anti-inflammatory drugs (NSAID)

Abstract

mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. J Exp Med 1991;173:429-37. 4 Sanderson CJ, Campbell HD, Young IG. Molecular and cellular biology of eosinophil differentiation factor (interleukin-5) and its effects on human and mouse B cells. Immunol

Nimesulide — Actions and Uses

“…Analysis in plasma and other biological fluids as well as in solids of nimesulide and its metabolites can be performed by high performance liquid chromatography (HPLC) using reverse phase columns and UV detection [29,30,37] (see also Chapter 2; Bernareggi and Rainsford), and HPLC combined with mass spectrometry [38][39][40][41]. The HPLC methods mostly employ either aqueous (with or without buffers such as phosphate) acetonitrile or methanol mixtures.…”

“…The HPLC methods mostly employ either aqueous (with or without buffers such as phosphate) acetonitrile or methanol mixtures. In water based systems there will be two ionised states of nimesulide (with and without protonation of the amino group) present whereas the use of acidic phosphate buffers will control this and enable the non-ionised form to be determined [41].…”

“…Determination of nimesulide in solid dosage forms has been undertaken by reverse-phase HPLC using electrochemical detection [41], or by fluorimetry using diazotisation of the drug with N-(1-naphthyl) ethylene [42], or by second order derivative UV spectrophotometry [43].…”

“…The regional absorption of nimesulide in the GI tract was studied in nine healthy subjects using a special delivery system (InteliSite ® capsules) combined with gamma-scintigraphy [41]. These capsules are radio-frequency activated, non-disintegrating devices capable of delivering therapeutic agents to specific regions of the GI tract in a non-invasive manner [42].…”

“…COX-1 is mainly involved in normal physiological functions while COX-2 is usually involved in the inflammatory response or some physiological functions that require prostaglandins transiently such as in gastric ulcer healing, some renal functions, atherothrombosis, bone metabolism, insulin secretion, vascular functions, regulation of immune functions and ovulation (Fig. 3) [41][42][43][44]. In the stomach, COX-1 forms the prostaglandins that help maintain gastric mucosal integrity that include reduction in acid output, increase in mucus discharge, increase in bicarbonate secretion, enhancement of blood flow and protection against mast cell degranulation [42].…”