Incidence of hepatitis C virus infection in patients with chronic kidney disease on conservative therapy

Cavoli, Gioacchino Li; Ferrantelli, Angelo; Bono, Luisa; Tortorici, Calogera; Giammarresi, Carlo; Zagarrigo, Carmela; Schillaci, Onofrio; Tralongo, Angelo; Soresi, Maurizio; Rotolo, Ugo

doi:10.1016/j.ijid.2011.04.001

Cited by 17 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…International studies have shown variable results. In an Italian study of pre-dialysis CKD patients, incidence of hepatitis C was found to be 6.25% in 320 patients 13. In another study in Spain, hepatitis C antibody was present in 7.9% of 226 CKD patients with frequency of 13% in patients with creatinine clearance less than 30 ml/min 14.…”

Section: Discussionmentioning

confidence: 95%

Frequency of Hepatitis C in hospitalized patients with chronic kidney disease

et al. 2017

View full text Add to dashboard Cite

Background and Objectives:Hepatitis C and chronic kidney disease (CKD) are major global health problems and are highly prevalent in Pakistan. There is limited information on prevalence of hepatitis C in patients with CKD not yet on dialysis. The objective of this study was to determine the frequency of hepatitis C in hospitalized chronic kidney disease patients at a tertiary care center in Pakistan.Methods:The study design was cross-sectional in nature. Patients between ages of 20-80 years with CKD not previously on renal replacement therapy and who were admitted to nephrology ward at a tertiary care facility were included. Hepatitis C was tested using 3rd generation enzyme linked immunosorbent assay (ELISA). Hepatitis C RNA was tested by polymerase chain reaction (PCR) in patients with positive ELISA.Results:A total of 180 patients were included in the study. Mean age of patients was 48.7±14.9 years. Of all patients, 105 (58.3%) were males and 75 (41.7%) were females, 152 (84.4%) had hypertension, 113 (62.8%) had diabetes mellitus and 26 (14.9%) had known cardiovascular disease. Mean eGFR of patients was 11.4±9.4 ml/min/1.73 m2. Of all patients with CKD, 49 (27.2%) had hepatitis C test positive by ELISA. Hepatitis C PCR testing was done in 39 patients with hepatitis C ELISA positive status and 29 (74.4%) tested positive. Risk factors and clinical characteristics of patients with and without positive hepatitis C antibody by ELISA were similar.Conclusion:A significant proportion of hospitalized CKD patients have hepatitis C. Strict universal infection control measures should be implemented in nephrology wards to prevent transmission of hepatitis C infection.

show abstract

Section: Discussionmentioning

confidence: 95%

Frequency of Hepatitis C in hospitalized patients with chronic kidney disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…13,14 The prevalence of HCV seropositivity increases with advanced CKD stage. 15 In addition, infection with HCV has also been reported to be significantly positively associated with proteinuria. 16 In a retrospective cohort study involving over 470,000 adult veterans, patients with HCV infection were more likely to develop ESRD than HCV-seronegative patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of HCV Infection on Diabetes Patients for the Risk of End-Stage Renal Failure

Hwang

Jiang

et al. 2016

Medicine

View full text Add to dashboard Cite

Both diabetes mellitus (DM) and hepatitis C virus infection (HCVI) are associated with chronic kidney disease (CKD). The aim of this study was to evaluate whether HCVI increases the risk of end-stage renal disease (ESRD) in patients with DM.The National Health Insurance Research database of Taiwan was used to conduct this study. After excluding patients with a prior history of CKD, all patients with a first diagnosis of DM from January 1, 2000 to December 31, 2002 were enrolled. The patients who also had HCVI were defined as index cases (HCV group, n = 9787). A comparison cohort at a 1:1 ratio of random incident patients with DM without HCVI matched by age, sex, age at the diagnosis of DM, duration between the diagnosis of DM and the index date, and various comorbidities through propensity score matching were recruited (non-HCV group, n = 9787). The patients were followed until December 31, 2011.The cumulative incidence rate of developing ESRD was significantly higher in the HCV(+) group than in the non-HCV group (P = 0.008). The incidence rate ratio (IRR) for the risk of ESRD was also significantly higher in the HCV(+) group (IRR: 1.44; 95% CI: 1.09–1.89) than in the non-HCV group, especially for those with a younger age (<50 years; IRR: 2.05; 95% CI: 1.22–3.45) and HCVI within 4 years after the diagnosis of DM (IRR: 1.85; 95% CI: 1.16–2.97). After adjusting for comorbidities in multivariate Cox proportional hazard regression analysis, HCVI (HR: 1.47; 95% CI: 1.11–1.93) was an independent factor for developing ESRD in the patients with DM. After starting dialysis for ESRD, the HCV(+) patients had a similar mortality rate to those without HCVI (P = 0.84).HCVI increases the risk of developing ESRD in patients with DM, especially in younger patients and in those who develop HCVI sooner after a diagnosis of DM.

show abstract

“…The studies reported in Table reveal a high frequency of HCV infection in patients with advanced pre‐dialysis CKD; some authors concluded that the current risk factors for HCV in patients receiving dialysis differ consistently from those identified two decades ago, at least in developed countries . The implementation of infection control procedures to prevent the spread of bloodborne pathogen agents (including HCV), the screening of blood for HCV, and the use of erythropoietin‐stimulating agents has dramatically reduced the post‐transfusion and nosocomial transmission of HCV within hemodialysis units.…”

Section: Hcv and Pre‐dialysis Ckd: Risk Factorsmentioning

confidence: 99%

The epidemiology of HCV infection in patients with advanced CKD/ESRD: A global perspective

Fabrizi

2018

Seminars in Dialysis

View full text Add to dashboard Cite

Liver disease in patients with chronic kidney disease (CKD) is most commonly due to hepatitis C virus (HCV) and contributes to increased rates of mortality. Among the pre-dialysis population, the estimated prevalence of anti-HCV positivity is based on few, limited-size studies. In hemodialysis patients however, HCV remains very prevalent despite large declines in seropositivity rates in dialysis facilities in developed countries after preventive measures were adopted in the 1990s. Recent surveys indicate that the HCV seropositivity prevalence ranges from 1.4%-28.3%, and 4.7%-41.9%, among maintenance dialysis patients in developed and developing countries respectively. Although the full extent of dialysis unit-associated HCV transmission is unknown, outbreaks continue to occur, regardless of health system infrastucture. According to US Centers for Disease Control data, over 50% of health care-associated HCVoutbreaks reported from 2008 to 2015 occurred within dialysis facilities. Strict adherence to infection control procedures and routine serologic screening plays a pivotal role in preventing transmission of HCV within hemodialysis units, even in the setting of low HCV prevalence. With the advent of directly acting antivirals, cure of HCV-infected patients on maintenance hemodialysis will help reduce transmission within units and further lower the frequency of HCV infection.

show abstract

Incidence of hepatitis C virus infection in patients with chronic kidney disease on conservative therapy

Cited by 17 publications

References 5 publications

Frequency of Hepatitis C in hospitalized patients with chronic kidney disease

Frequency of Hepatitis C in hospitalized patients with chronic kidney disease

Impact of HCV Infection on Diabetes Patients for the Risk of End-Stage Renal Failure

The epidemiology of HCV infection in patients with advanced CKD/ESRD: A global perspective

Contact Info

Product

Resources

About