Incidence of hemoglobinopathies in Northwest Paraná, Brazil

Abstract

Immigrants from many parts of the world settled in Paraná State in Brazil, contributing to the diversified genetic patrimony of its population. This characteristic led us to investigate, for the first time, the incidence of hemoglobinopathies in the population of one city in Paraná. A total of 585 blood samples were collected from individuals living in Umuarama. Hemoglobinopathy tests were carried out using the classical methodology. The results show that 93.17% have the normal electrophoretic pattern (AA); 2.73% have the beta-thalassemia trait; 2.05% have the sickle cell trait (AS); 1.37% are heterozygous for alpha-thalassemia; 0.34% heterozygous for hemoglobin C (AC); 0.17% have both alpha-thalassemia and sickle cell traits and 0.17% are heterozygous for alpha and beta-thalassemia. A comparison of these results with other works suggests that the frequency of hemoglobinopathies can significantly vary between cities within the same state. This fact may be attributed to the miscegenation of the population or even to the diverse prevalence of hemoglobinopathies in distinct populations. Rev. bras. hematol. hemoter. 2008;30(4):287-291.

Prevalence of βS-globin gene haplotypes, α-thalassemia (3.7 kb deletion) and redox status in patients with sickle cell anemia in the state of Paraná, Brazil

“…The intense miscegenation of the Brazilian population has resulted in regional differences in ethnic composition that have led to a heterogeneous distribution of the Hb S gene ( Wenning et al , 2000 ; Chinelato-Fernandes and Bonini-Domingos, 2005 ; Seixas et al , 2008 ; Silva Filho et al , 2010 ). Paraná state, located in southern Brazil, has a 1.52% prevalence for the heterozygous S gene ( Watanabe et al , 2008 ).…”

Pesquisa de hemoglobinopatias em cães da região metropolitana do Rio de Janeiro portadores de anemia crônica

“…As hemoglobinopatias são um assunto de interesse crescente entre as autoridades de saúde e pesquisadores em medicina humana no Brasil, uma vez que diferentes estudos apontam que estes distúrbios genéticos são um problema de saúde pública nacional, e desde 2001 o Ministério da Saúde tornou obrigatória a pesquisa de hemoglobinopatias em recém-nascidos, usando o teste de Guthrie (Seixas et al 2008).…”