Incidence of functional intestinal disorders and postinfectious irritable bowel syndrome following a waterborne viral gastroenteritis outbreak

Zanini, Bárbara; Caselani, Francesca; Magni, Alberto; Roga, Ance; Bandera, Floriana; Ricci, Chiara; Cassarino, C; Romanini, Maria Victoria; Cecchi, D; Vassallo, F; Scarcella, Carmelo; Lanzini, Alberto

doi:10.1136/gut.2011.239301.341

Cited by 3 publications

(6 citation statements)

References 2 publications

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“…It is even known that not only the severity but also the type of infection may play a role. 33,34 Unfortunately, in our study the subgroups were too small to gain similarly informative results.…”

Section: Discussionmentioning

confidence: 73%

“…Furthermore, Mearin et al 30 reported vomiting and prolonged abdominal pain as predictors for functional symptoms, however, for postinfectious dyspepsia instead of PI-IBS. In contrast to the studies mentioned above, Zanini et al 33 revealed no association of PI-IBS and the discussed risk factors and Neal et al 37 found vomiting as a protective factor. In this context, two hypotheses come into consideration: Firstly, vomiting may reflect a higher severity of the infection and in consequence increases the PI-IBS risk 34 or secondly, vomiting affects mainly the upper GI tract and moreover may reduce the pathogen load and therefore decreases the PI-IBS risk.…”

Section: Discussionmentioning

confidence: 77%

“…12,28,31 We found an association of female sex and PI-IBS, which is similar consistent with previous research, 11,12,32 although we were unable to fully exclude the role of chance, due to small sample size. Of note, one recently published study 33 could neither confirm young age nor female sex as risk factors for PI-IBS. The authors used the Gastrointestinal Symptom Rating Scale at baseline and after 3 and 6 months.…”

Section: Discussionmentioning

confidence: 84%

“…Dunlop et al 40 found higher anxiety, depression, and fatigue scores in PI-IBS subjects and also higher stress levels. 41 In contrast, the study of Zanini et al 33 found no association of PI-IBS and pre-existing diagnosis of anxiety or depression, but this might be due to the fact that no validated psychometric instruments were used. In accordance with these results, we found no association between PI-IBS occurrence and a reported history of a depressive or anxiety disorder, but a strong association of PI-IBS and psychometric measurements.…”

Section: Discussionmentioning

confidence: 92%

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Postinfectious irritable bowel syndrome after travelers' diarrhea – a cohort study

Schwille‐Kiuntke¹,

Enck²,

Polster

et al. 2015

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 92%

See 2 more Smart Citations

Postinfectious irritable bowel syndrome after travelers' diarrhea – a cohort study

Schwille‐Kiuntke¹,

Enck²,

Polster

et al. 2015

Neurogastroenterology Motil

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“…More than 10% of IBS patients develop symptoms after an episode of acute gastroenteritis, which is called post-infectious IBS (PI-IBS). 130,131 Peripheral blood mononuclear cells from patients with PI-IBS show T cell activation and an increased level of pro-inflammatory cytokines, including TNF and IL-6. 132 Thus, at least in a subpopulation of patients with IBS, low grade immune activation is likely to contribute to the pathogenesis.…”

Section: Irritable Bowel Syndromementioning

confidence: 99%

Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome

Ratanasirintrawoot

Israsena

2016

J Neurogastroenterol Motil

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Irritable bowel syndrome is one of the most common functional gastrointestinal (GI) disorders that significantly impair quality of life in patients. Current available treatments are still not effective and the pathophysiology of this condition remains unclearly defined. Recently, research on intestinal stem cells has greatly advanced our understanding of various GI disorders. Alterations in conserved stem cell regulatory pathways such as Notch, Wnt, and bone morphogenic protein/TGF -β have been well documented in diseases such as inflammatory bowel diseases and cancer. Interaction between intestinal stem cells and various signals from their environment is important for the control of stem cell self-renewal, regulation of number and function of specific intestinal cell types, and maintenance of the mucosal barrier. Besides their roles in stem cell regulation, these signals are also known to have potent effects on immune cells, enteric nervous system and secretory cells in the gut, and may be responsible for various aspects of pathogenesis of functional GI disorders, including visceral hypersensitivity, altered gut motility and low grade gut inflammation. In this article, we briefly summarize the components of these signaling pathways, how they can be modified by extrinsic factors and novel treatments, and provide evidenced support of their roles in the inflammation processes. Furthermore, we propose how changes in these signals may contribute to the symptom development and pathogenesis of irritable bowel syndrome.

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Experience of using metaprebiotics in the treatment of certain functional gastrointestinal disorders

et al. 2020

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Introduction. Functional gastrointestinal disorders (FGID) occupy one of the leading positions among intestinal pathologies. At present, scientific data indicate the lack of efficiency of existing methods of FGID treatment and the need for further research. This study is devoted to the assessment of the impact of STIM Lax and STIM treatment on clinical manifestations in patients with FC and FD.Aim of the study. Evaluation of the effectiveness of biologically active additives (BAA) STIM and STIM Laks in 39 patients with functional gastrointestinal disorders. Objectives of the study: to evaluate the effect of the drug on clinical symptoms according to an individual diary and using specialized questionnaires with a score of symptoms before and after treatment.Materials of the research. 39 patients divided into two groups were admitted to the research. Of these, 20 patients were with FC (4 men and 16 women; mean age – 40.3 ± 8.9 years). Monotherapy with STIM Laks was conducted (1 tablet 3 times a day for 30 days), and 19 FD patients (10 men and 9 women; mean age – 36.9 ± 14.1 years). Before and after the course of treatment a carbolene sample was conducted, stool form and frequency, intensity of flatulence, purring, transfusion, abdominal pain were clinically evaluated.Results. Therapy of FС and FD with STIM and STIM Laks effectively reduces the frequency and intensity of clinical symptoms, normalizes the transit time of the carbolene sample, the frequency of stool. Increase of flatulence was observed in 7 (17.9%) patients, its resolution within 1–3 days led to a decrease in the dose of the drug, without affecting the end result.Conclusions. This study indicates a high efficacy and good tolerability of treatment with STIM Laks and STIM in patients with FGID.

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Incidence of functional intestinal disorders and postinfectious irritable bowel syndrome following a waterborne viral gastroenteritis outbreak

Cited by 3 publications

References 2 publications

Postinfectious irritable bowel syndrome after travelers' diarrhea – a cohort study

Postinfectious irritable bowel syndrome after travelers' diarrhea – a cohort study

Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome

Experience of using metaprebiotics in the treatment of certain functional gastrointestinal disorders

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