Incidence of fish-borne trematode infections and associated factors: results from a cohort study in highly endemic communities in northern Vietnam

Nguyen‐Anh, Tuan; Dermauw, Véronique; Bui, Dung Thi; Dahma, Hafid; Le, Dung Thuy; Nguyen, Hien Thi Thu; Trung, Dung; Dorny, Pierre; Losson, Bertrand; Vandenberg, Olivier

doi:10.1007/s00436-023-07846-y

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…In Vietnam, the pooled prevalence of clonorchiasis increased during the years 2010 to 2019, although it is not significantly different from the earlier periods. This could be attributed to more endemic foci being investigated in the northern parts of the country over the past decades, such as the Thac Ba lake region, Yen Bai, and Thanh Hoa provinces, where the prevalence of C. sinensis infection is high (40.4%) with prevalence at the commune level ranging between 26.5% and 53.3% [46] The incidence rate of fishborne trematode reinfection was as high as 21.4/100 person-years [47]. Major risk factors for infection include the behavior of eating raw fish, low education level, lack of treatment, and poor hygienic sanitation [46][47][48].…”

Section: Discussionmentioning

confidence: 99%

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis

Sota,

Andityas,

Kotepui

et al. 2024

Infect Dis Poverty

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Background Opisthorchiasis and clonorchiasis, caused by Opisthorchis viverrini and Clonorchis sinensis, respectively, are significant yet neglected foodborne trematodiases in the Great Mekong Subregion (GMS). Despite the reporting of the prevalence of these human liver flukes in the region over the past decades, there has been a lack of a comprehensive and systematic consolidation of this data. Therefore, we aimed to conduct a thorough systematic review and meta-analysis to synthesize and analyze time-trend prevalence estimates of both O. viverrini and C. sinensis across the GMS for the past 30 years. Methods This study undertakes a systematic review using a comprehensive search for published articles in PubMed, EMBASE, Scopus, Cochrane and Thai Journal Online databases until early 2023. The pooled prevalence of O. viverrini and C. sinensis infection was analyzed through a random-effects meta-analysis, with meta-regression analysis used to quantify associations with study characteristics. Sub-group analysis was conducted, whenever comparison data were available, to assess the risk of O. viverrini and C. sinensis infection in each GMS country. Heterogeneity among studies was assessed using the Q statistic and quantified by using the I2 Index. Results From a total of 2997 articles, 155 articles comprising 218 datasets and 751,108 participants were included for review. The GMS prevalence of O. viverrini was 21.11% [45,083/260,237; 95% confidence interval (CI): 17.74–24.47%]. Pooled prevalence estimates were highly observed in Laos (34.06%, 95% CI: 26.85–41.26%), followed by Thailand (18.19%, 95% CI: 13.86–22.51%), and Cambodia (10.48%, 95% CI: 5.52–15.45%). Myanmar and Vietnam had limited data sources for calculation. Clonorchis sinensis infection in GMS was 25.33% (95% CI: 18.32–32.34%), with Guangxi, China, exhibiting the highest prevalence rates at 26.89% (95% CI: 18.34–35.43%), while Vietnam had a prevalence rate of 20.30% (95% CI: 9.13–31.47%). O. viverrini prevalence decreased significantly over time, whereas C. sinensis infection appeared to be stable consistently over time in both China and Vietnam. Conclusions This comprehensive study, drawing from the largest datasets to date, offers an in-depth systematic prevalence review of human liver flukes in the Greater Mekong Subregion. It underscores the imperative for systematic surveillance, data collection, and the implementation of intervention and control measures for these infectious diseases of poverty. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis

Sota,

Andityas,

Kotepui

et al. 2024

Infect Dis Poverty

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Liver Flukes: Clonorchis and Opisthorchis

Saijuntha,

Sithithaworn,

Wangboon

et al. 2024

Advances in Experimental Medicine and Biology

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Effectiveness of health education in improving knowledge, attitude and practice related to foodborne zoonotic trematodes in Vietnam, with a particular focus on Clonorchis sinensis

Nguyen,

Bui,

Losson

et al. 2024

Tropical Med Int Health

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ObjectiveFoodborne zoonotic trematodes (FZT), which infect the liver, lungs and intestines of humans, are an emerging public health concern in tropical countries including Vietnam. In northern Vietnam, Clonorchis sinensis is recognised as the most important species of the FZT. Up to now, small‐scale studies conducted in the country have indicated that health education could improve participants' knowledge and practices related to clonorchiasis, however strong evidence is still lacking. We conducted an intervention trial between 2020 and 2021 in four communes in Yen Bai and Thanh Hoa province, aiming to evaluate the impact of an extended educational package on knowledge, attitude and practices related to clonorchiasis, as well as on knowledge on the large liver fluke and minute intestinal flukes.MethodsTo this end, baseline and post‐intervention questionnaires were conducted. Generalised estimating equations models were run to analyse the impact of the intervention on knowledge, attitudes and practices over time in the intervention versus control group. Finally, 172 people in the intervention group and 162 in the control group were included for analysis.ResultsResults demonstrated that the intervention significantly improved clonorchiasis knowledge, attitudes and practices, with higher odds for a correct knowledge response (odds ratio (OR) = 2.80, 95% confidence interval (CI) = 1.84–4.27, p‐value < 0.001), increased average mean attitude score (mean = 0.363, 95%CI = 0.182–0.544, p‐value < 0.001), and a reduced odds of consuming raw fish (OR = 0.15, 95%CI = 0.06–0.40, p = 0.002) in the intervention group compared to the control group post‐intervention versus baseline. Additionally, participants in the intervention group exhibited enhanced basic knowledge of the large liver fluke and minute intestinal flukes post‐intervention.ConclusionsThese findings demonstrate the potential of health education programs in preventing clonorchiasis in endemic areas, emphasising the importance of continued health education as a critical component of integrated control programs for clonorchiasis.

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Incidence of fish-borne trematode infections and associated factors: results from a cohort study in highly endemic communities in northern Vietnam

Cited by 3 publications

References 32 publications

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis

Liver Flukes: Clonorchis and Opisthorchis

Effectiveness of health education in improving knowledge, attitude and practice related to foodborne zoonotic trematodes in Vietnam, with a particular focus on Clonorchis sinensis

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