Incidence of Epilepsy in Childhood and Adolescence: A Population‐Based Study in Nova Scotia from 1977 to 1985

Camfield, Carol; Camfield, Peter; Gordon, Kevin; Wirrell, Elaine; Dooley, Joseph M.

doi:10.1111/j.1528-1157.1996.tb00506.x

Cited by 268 publications

(175 citation statements)

References 17 publications

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“…Such an approach ensures the exclusion of children with other disorders that may be difficult to distinguish from epilepsy. The strong similarities between our study and other "population-based'' studies with respect to basic demographic and clinical features suggests that no significant biases affected recruitment of the cohort [(1), Nova Scotia, Canada (12), the Netherlands (lo), and Finland (13)]. …”

Section: Discussionmentioning

confidence: 81%

Newly Diagnosed Epilepsy in Children: Presentation at Diagnosis

et al. 1999

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Summary:Purpose: The current understanding of epilepsy has changed significantly in the past 2 decades. This report presents a description of newly diagnosed childhood-onset epilepsy, with a special emphasis on epilepsy syndromes, in a large, prospectively ascertained community-based cohort evaluated and diagnosed in the mid-1990s.Methods: Children, aged 0 through 15 years at the time of the first seizure, were prospectively identified at the time of diagnosis of epilepsy through the practices of 16 of the 17 child neurologists in Connecticut as well as five adult neurologists and seven pediatricians from January 1993 through December 1997. Parents were interviewed, and all relevant medical records were reviewed. classification of seizures and of epilepsy syndromes was done for each child by each of three pediatric neurologists, Discrepancies were resolved in conference.Results: A total of 613 children was recruited into the study. The median age at time of the first seizure was 5.3 years. Half the cohort was boys. Eighteen percent had a remote symptomatic etiology. Epilepsy syndromes were classifiable in all but four children, although some syndromes are, by definition, relatively nonspecific. In this childhood-onset cohort, 58.6% of the syndromes were localization related, 29.0% generalized, and 12.4% undetermined as to whether focal or generalized. Benign rolandic epilepsy occurred in 10% of the cohort. Primarily generalized syndromes accounted for 20.6%, with childhood absence being the single most common syndrome in this subgroup (12.1 % of the cohort). Secondarily generalized syndromes accounted for 8.5% of the total, with infantile spasms being the most common in this grouping (3.9% of the cohort).Conclusions: This study presents a description of childhoodand adolescent-onset epilepsy as it is diagnosed and evaluated in the 1990s in one state in the United State and based on current classification guidelines. The results should be generalizable to the rest of the country. The prognostic value of early identification of epilepsy syndromes will be determined through subsequent follow-up of this cohort.

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Section: Discussionmentioning

confidence: 81%

Newly Diagnosed Epilepsy in Children: Presentation at Diagnosis

et al. 1999

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“…Neonates have the greatest predisposition to seizures of any age group, with the seizure incidence ranging from 1 to 5 per 1000 live births. [1][2][3][4][5][6][7][8][9] The distribution of seizures within the neonatal period, however, has not been clearly defined.…”

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confidence: 99%

Neonatal Seizures

1999

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OBJECTIVE:To examine the influence of gestational age on seizures in the neonatal intensive care unit. STUDY DESIGN:A cohort of 4165 neonates admitted to a university intensive care unit between 1986 and 1995. The incidence, time of onset, and etiology of neonatal seizures in the cohort were distributed by gestational age. Logistic regression and t test were used to examine the relationship between gestational age and seizures in the neonatal intensive care unit. RESULTS:Seizures occurred in 356 (8.6%) infants. The seizure rate was parabolically related to gestational age, such that infants at 30 to 36 weeks' gestation had a 4.8% rate compared with 11.9% and 14.1% rates for infants Ͻ30 and Ͼ36 weeks, respectively (p Ͻ 0.001). Seizures manifested earlier in infants Ͻ30 weeks (2.3 Ϯ 5.6 days of life) and Ͼ36 weeks (3.7 Ϯ 8.7 days) gestational age compared with neonates 30 to 36 weeks (10.4 Ϯ 14.5 days) (p Ͻ 0.001). Intraventricular hemorrhage was the principal etiology underlying the higher seizure rate for infants Ͻ30 weeks (p Ͻ 0.001). Hypoxic-ischemic encephalopathy and congenital malformations were primary factors for infants Ͼ36 weeks (p Ͻ 0.01). Nervous system infections were evenly distributed across gestational age. CONCLUSION:Gestational age exerts a considerable influence on the incidence, onset, and etiology of neonatal seizures.

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“…Muitos estudos prévios sobre a prevalência e a incidência de epilepsia já foram publicados, com resultados variando de 0,9 a 57 casos por 1.000 habitantes para a prevalência, e 26 a 190 casos por 100.000 habitantes para a incidência [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . Muitas dessas variações ocorreram devido a diferenças metodológicas, como definição de epilepsia, critérios diagnósti-cos, ou avaliação prospectiva ou retrospectiva dos dados 27 .…”

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“…Muitos estudos avaliando a prevalência de epilepsia estão disponíveis na literatura, mas poucos estimaram a incidência de epilepsia em uma população específica de crianças [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] .…”

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Incidence of epilepsy and seizure disorders in childhood and association with social determinants: a birth cohort study

Nunes

Geib²,

Apego³

2011

J Pediatr (Rio J)

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Objective: To investigate the incidence and prevalence of epilepsy and seizure disorders during childhood, and their relationship to selected social determinants. Methods:Population-based birth cohort study, with children born between January 1st and December 31st, 2003 in the city of Passo Fundo (RS), Brazil. Data was prospectively collected in two stages. In the first one, the Questionnaire of Neurologic Tracking for Epilepsy (QNT-E) was applied at the children's homes, together with the assessment of social determinants of health. Constructs of social position (economical class, mother's educational level, marital status and occupation), biological and behavioral factors (alcohol and tobacco consumption during pregnancy, number of prenatal appointments, and use of medicines during pregnancy), and psychosocial factors (religious meetings attendance) were analyzed. In the second stage, children with a positive QNT-E were submitted to neuroclinical assessment for diagnostic confirmation.Results: Eleven cases of epilepsy, 27 of febrile seizures, 10 of neonatal seizures, 8 of single seizures, besides 26 patients with nonepileptic paroxysmal events, were identified. The incidence rate of epilepsy was 7/100,000 children and the prevalence 65.2/10,000 children. Nine children had active epilepsy, giving a point prevalence of 53.3/10,000 children. After multivariate analysis, no social determinants could be significantly related to epilepsy. Conclusions:In this study, a low incidence rate of epilepsy was reported in contrast to almost a double incidence of febrile seizures and non-epileptic paroxysmal events. Moreover, the achievement of an accurate diagnosis of epilepsy in developing countries is still a challenge, in order to avoid misdiagnosis.J Pediatr (Rio J). 2011;87(1):50-56: Epilepsy, epileptic syndromes, incidence, prevalence, childhood. ResumoObjetivo: Investigar a incidência e prevalência de epilepsia e distúrbios convulsivos na infância e sua relação com os determinantes sociais escolhidos.Métodos: Estudo de coorte de nascimento de base populacional, com crianças nascidas entre 1/01 e 31/12/2003 na cidade de Passo Fundo (RS). Os dados foram coletados prospectivamente em duas etapas. Na primeira, foi aplicado o Questionário de Rastreamento Neurológico para Epilepsia (QRN-E) durante uma visita à casa das crianças, juntamente com a avaliação dos determinantes sociais da saúde. Foram analisados construtos de posição social (classe econômica, escolaridade, estado civil e ocupação da mãe), fatores biológicos e comportamentais (consumo de álcool, tabaco e medicamentos na gravidez, e consultas pré-natais) e fatores psicológicos (participação em cerimônias religiosas). Na segunda etapa, as crianças cujos QRN-E apresentaram resultado positivo foram submetidas a avaliação neuroclínica para confirmação do diagnóstico. Resultados:Foram identificados 11 casos de epilepsia, 27 de convulsões febris, 10 de convulsões neonatais, 8 de crise única, além de 26 pacientes com eventos paroxísticos não epilépticos. A incidê...

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Incidence of Epilepsy in Childhood and Adolescence: A Population‐Based Study in Nova Scotia from 1977 to 1985

Cited by 268 publications

References 17 publications

Newly Diagnosed Epilepsy in Children: Presentation at Diagnosis

Newly Diagnosed Epilepsy in Children: Presentation at Diagnosis

Neonatal Seizures

Incidence of epilepsy and seizure disorders in childhood and association with social determinants: a birth cohort study

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