Incidence of Epilepsies and Epileptic Syndromes in Children and Adolescents: A Population‐Based Prospective Study in Germany

Freitag, Christine M.; May, Theodor W.; Pfäfflin, Margarete; König, Stephan; Rating, D.

doi:10.1046/j.1528-1157.2001.042008979.x

Cited by 113 publications

(118 citation statements)

References 34 publications

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“…We recorded idiopathic epilepsies as a commonest etiology in 53.5% of children that is closed to other report (18), while other reported symptomatic epilepsy was the commonest etiology (61%) (19). Idiopathic focal epilepsies are the most frequent epilepsy syndromes in children.…”

Section: öZetmentioning

confidence: 47%

Clinical profile of childhood focal epilepsies in Jordan

Khreisat¹

2011

Gaziantep Med J

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The present study was done in order to obtain a baseline profile of childhood focal epilepsies. Subjects included in this study were children suffering from focal epilepsy with age above 2 years who attended the Pediatric Neurology Clinic in Queen Rania Hospital for Children in Jordan. The data were obtained: age, sex, detailed of seizures type, age at first unprovoked seizure, family history of seizures, history of febrile seizures, etiological, socioeconomic class, additional neuro-impairment, electroencephalography (EEG) and brain imaging finding and the use of antiepileptic drugs, the results were recorded for further study. A total of 100 cases of focal epilepsy were enrolled in the study, 59 were male. Simple partial type recorded in 48%, simple partial with secondary generalization in 17% and complex partial seizure in 35%. In partial onset seizures the peak age was between 11-14 years and complex partial seizures between ages 6-10 years. Twenty-six patients had a family history of epilepsy, 91% of low socioeconomic class. Thirteen % of cases have history of febrile seizures, while symptomatic epilepsy was found in 48%. Twenty-five children had hypoxic-ischemic encephalopathy. The most common neurological impairment was learning difficulties with 35%. EEG was normal in 20% and monotherapy was used in 68% and 33% had bad control (intractable). The pattern of focal epilepsies in our country do not differ from that of developed countries, identifying the etiology is important to plan prevention. Keywords: Complex partial seizure; epilepsy; simple partial seizure Özet Bu çalışma, çocukluk çağı fokal epilepsilerin bazal profilini ortaya koymak için yapıldı. Bu çalışmaya katılan olgular, Ürdün'de Kraliçe Rania Çocuk Hastanesi Pediatrik Nöroloji Kliniği'ne başvuran 2 yaş üzeri fokal epilepsili çocuklardı. Yaş, cinsiyet, nöbet tipinin detayı, ilk uyarılmamış nöbet yaşı, nöbetlerin aile hikayesi, febril nöbetlerin hikayesi, etyolojik, sosyoekonomik sınıf, ilave nörolojik bozukluk, elektroensefalografi (EEG) ve beyin görüntüleme bulguları, ve antiepileptic ilaç kullanımı verileri toplandı, sonuçlar daha ileriki çalışma için kaydedildi. Bu çalışmaya total 100 fokal epilepsili vaka alındı, bunların 59'u erkekti. Basit parsiyet tip %48'inde, sekonder generalizeli basit parsiyel %17'inde ve kompleks parsiyel nöbetler %35'inde kaydedildi. Parsiyel başlangıçlı nöbetlerin pik yaptığı yaş 11-14 idi ve kompleks parsiyel nöbetler 6-10 yaşları arasındaydı. Yirmi altı hastada epilepsinin aile hikayesi vardı, %91'i düşük sosyoekenomik sınıftandı. Hastaların %13'ünde febril nöbet hikayesi varken semptomatik epilepsi %48'inde vardı. Yirmi beş çocuk hipoksik-iskemik ensefalopatiliydi. En yaygın nörolojik bozukluk %35 ile öğrenme güçlüğü idi. EEG %20'inde normaldi ve %68'inde monoterapi kullanıldı ve %33'ünde kötü kontrol (tedaviye cevap vermeyen) vardı. Bizim ülkemizde fokal epilepsilerin şekli gelişmiş ülkelerdekinden farklı değildir, etyolojinin belirlenmesi önleme planı için önemlidir. Anahtar kelimeler: Kompleks parsiy...

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Section: öZetmentioning

confidence: 47%

Clinical profile of childhood focal epilepsies in Jordan

Khreisat¹

2011

Gaziantep Med J

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“…Muitos estudos prévios sobre a prevalência e a incidência de epilepsia já foram publicados, com resultados variando de 0,9 a 57 casos por 1.000 habitantes para a prevalência, e 26 a 190 casos por 100.000 habitantes para a incidência [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . Muitas dessas variações ocorreram devido a diferenças metodológicas, como definição de epilepsia, critérios diagnósti-cos, ou avaliação prospectiva ou retrospectiva dos dados 27 .…”

Section: Discussionunclassified

“…Em estudos prévios focados somente na população infantil, alguns autores relataram uma predominância da epilepsia focal 2,3,5,8,[11][12][13][14] , e outros da generalizada 6,7,9,10,15 , como em nosso estudo.…”

Section: Discussionunclassified

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Incidence of epilepsy and seizure disorders in childhood and association with social determinants: a birth cohort study

Nunes

Geib²,

Apego³

2011

J Pediatr (Rio J)

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Objective: To investigate the incidence and prevalence of epilepsy and seizure disorders during childhood, and their relationship to selected social determinants. Methods:Population-based birth cohort study, with children born between January 1st and December 31st, 2003 in the city of Passo Fundo (RS), Brazil. Data was prospectively collected in two stages. In the first one, the Questionnaire of Neurologic Tracking for Epilepsy (QNT-E) was applied at the children's homes, together with the assessment of social determinants of health. Constructs of social position (economical class, mother's educational level, marital status and occupation), biological and behavioral factors (alcohol and tobacco consumption during pregnancy, number of prenatal appointments, and use of medicines during pregnancy), and psychosocial factors (religious meetings attendance) were analyzed. In the second stage, children with a positive QNT-E were submitted to neuroclinical assessment for diagnostic confirmation.Results: Eleven cases of epilepsy, 27 of febrile seizures, 10 of neonatal seizures, 8 of single seizures, besides 26 patients with nonepileptic paroxysmal events, were identified. The incidence rate of epilepsy was 7/100,000 children and the prevalence 65.2/10,000 children. Nine children had active epilepsy, giving a point prevalence of 53.3/10,000 children. After multivariate analysis, no social determinants could be significantly related to epilepsy. Conclusions:In this study, a low incidence rate of epilepsy was reported in contrast to almost a double incidence of febrile seizures and non-epileptic paroxysmal events. Moreover, the achievement of an accurate diagnosis of epilepsy in developing countries is still a challenge, in order to avoid misdiagnosis.J Pediatr (Rio J). 2011;87(1):50-56: Epilepsy, epileptic syndromes, incidence, prevalence, childhood. ResumoObjetivo: Investigar a incidência e prevalência de epilepsia e distúrbios convulsivos na infância e sua relação com os determinantes sociais escolhidos.Métodos: Estudo de coorte de nascimento de base populacional, com crianças nascidas entre 1/01 e 31/12/2003 na cidade de Passo Fundo (RS). Os dados foram coletados prospectivamente em duas etapas. Na primeira, foi aplicado o Questionário de Rastreamento Neurológico para Epilepsia (QRN-E) durante uma visita à casa das crianças, juntamente com a avaliação dos determinantes sociais da saúde. Foram analisados construtos de posição social (classe econômica, escolaridade, estado civil e ocupação da mãe), fatores biológicos e comportamentais (consumo de álcool, tabaco e medicamentos na gravidez, e consultas pré-natais) e fatores psicológicos (participação em cerimônias religiosas). Na segunda etapa, as crianças cujos QRN-E apresentaram resultado positivo foram submetidas a avaliação neuroclínica para confirmação do diagnóstico. Resultados:Foram identificados 11 casos de epilepsia, 27 de convulsões febris, 10 de convulsões neonatais, 8 de crise única, além de 26 pacientes com eventos paroxísticos não epilépticos. A incidê...

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“…facilitan el diagnóstico y la clasificación sindrómica; lo que permite presumir cursos evolutivos y eventuales respuestas terapéuticas [6][7][8][9][10][11] . No obstante, las cifras disponibles respecto a la incidencia anual de epilepsia infantil son muy variables, oscilando entre 41 y 97 casos por 100.000 1,[12][13][14][15][16][17] , y generalmente debido a razones metodológicas que hacen difícil la comparación de resultados. En este sentido, la International League Against Epilepsy (ILAE), consciente de la conveniencia de disponer de referencias metodológicas comunes, ha propuesto una serie de pautas y/o normas conceptuales a seguir en los estudios epidemioló-gicos 18,19 .…”

Section: Introductionunclassified