Incidence of Dural Venous Sinus Thrombosis in Patients with Glioblastoma and Its Implications

Helmi, Ali; Chan, Alex Siu Wing; Towfighi, Sohrab; Kapadia, Anish; Perry, James; Ironside, Sarah; Machnowska, Matylda; Symons, Sean; Fox, Allan J.; Sahgal, Arjun; Maralani, Pejman Jabehdar

doi:10.1016/j.wneu.2019.01.039

Cited by 9 publications

(10 citation statements)

References 43 publications

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“…No such cases have reported the occurrence of CVST directly attributable to temozolomide. However, there is one study reporting CVST in a patient with a brain tumor treated with temozolomide, focal brain radiotherapy plus bevacizumab where the possible risk of thrombosis was attributed to the anti-angiogenic agent [3]. Our patient did not receive bevacizumab therapy.…”

Section: Discussionmentioning

confidence: 77%

“…CVST is an uncommon type of VTE [1][2][3][4]. The incidence of CVST was about 0.3-4% in cancer patients, with cancer increasing risk for CVST roughly 5-fold [5,7].…”

Section: Discussionmentioning

confidence: 99%

“…Extracranial VTE events such as deep venous thrombosis and pulmonary embolism have been widely reported in HGG; however, the incidence of CVST in HGG patients is not well established in the literature [4,5]. According to a recent study, the incidence of CVST in glioblastoma multiforme patients was reported to be 7.4% [3].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment of HGG also influences the risk of thrombosis [3,5,10]. Focal brain radiation with concurrent chemotherapy with temozolomide is the standard treatment of HGG.…”

Section: Discussionmentioning

confidence: 99%

“…T he patients with high-grade glioma (HGG) carry a high risk of venous thromboembolism (VTE) [1][2][3]. Cerebral venous sinus thrombosis (CVST) is an uncommon type of VTE whose diagnosis is often difficult due to its vague and non-specific clinical findings [1,4,5].…”

mentioning

confidence: 99%

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Cerebral venous sinus thrombosis with venous hemorrhagic infarct in a patient with high-grade glioma of the left thalamus

Thatikonda¹,

Pathak²

2021

IJCR

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Cerebral venous sinus thrombosis (CVST) is an uncommon type of venous thromboembolism whose diagnosis is often difficult due to its vague and non-specific clinical findings. Sometimes, the diagnosis is delayed as the symptoms were considered to be attributable to the underlying etiology, especially in patients with brain tumors such as high-grade glioma (HGG). We described the case of a 60-yearold male patient who presented with headache, generalized seizures, and right hemiparesis soon after receiving brain radiation and temozolomide therapy for HGG of the left thalamus. Initially, his symptoms were considered to be due to his underlying tumor but the subsequent imaging revealed left transverse, left sigmoid, and superior sagittal sinus thrombosis with venous hemorrhagic infarct of the left occipitoparietal lobe. The patient was started on anticoagulant therapy and symptoms resolved completely within a month. Clinicians should always consider CVST in the differential diagnosis of non-specific neurological symptoms, especially in patients with underlying brain tumors.

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Section: Discussionmentioning

confidence: 77%

“…CVST is an uncommon type of VTE [1][2][3][4]. The incidence of CVST was about 0.3-4% in cancer patients, with cancer increasing risk for CVST roughly 5-fold [5,7].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Treatment of HGG also influences the risk of thrombosis [3,5,10]. Focal brain radiation with concurrent chemotherapy with temozolomide is the standard treatment of HGG.…”

Section: Discussionmentioning

confidence: 99%