Incidence of Dogs Possessing Red Blood Cells with High K in Japan and East Asia.

Fujise, Hiroshi; Higa, Kazunari; Nakayama, Takahiro; Wada, Kayoko; Ochiai, Hideharu; Tanabe, Yuji

doi:10.1292/jvms.59.495

Cited by 35 publications

(29 citation statements)

References 13 publications

(16 reference statements)

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“…The present study confirmed that the Jindo breed has a high incidence of the HK phenotype, as reported by Fujise et al [7]. The hematological variables, except osmotic fragility, in HK Jindo dogs resembled those previously reported for HK phenotypic dogs [9,13,14,16].…”

supporting

confidence: 92%

“…the highest incidence (42%) of the HK phenotype of all dog groups in Japan and East Asia surveyed by Fujise et al [7]. However, there was no description of the two phenotypic variants of HK, i.e., HK/HG and HK/LG dogs in that report.…”

mentioning

confidence: 87%

“…Therefore, it has been thought that the gene for the HK phenotype might be inherent in dogs indigenous to Japan [12]. However, Fujise et al [7] reported recently that the HK phenotype is distributed not only in Japan but also in Korea.…”

mentioning

confidence: 99%

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Relation between Erythrocyte Reduced Glutathione and Glutamate Concentrations in Korean Jindo Dogs with Erythrocytes Possessing Hereditary High Activity of Na-K-ATPase and a High Concentration of Potassium.

Yamato

Lee

Chang

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. The concentrations of sodium, potassium, reduced glutathione (GSH) and free amino acids and Na-K-ATPase activity in erythrocytes were examined in 35 purebred Jindo dogs in Korea. The incidence of Jindo dogs with a high potassium concentration and high activity of Na-K-ATPase in erythrocytes (HK phenotype) was 25.7%. The erythrocyte GSH concentration in HK Jindo dogs varied widely, from 2.45 to 12.38 mmol/l of RBCs, and was positively correlated with the erythrocyte glutamate concentration. These results indicate that HK Jindo dogs have normal to very high levels of erythrocyte GSH, which might result from the varying quantity of Nadependent glutamate influx in the erythrocytes.-KEY WORDS: canine erythrocyte, Jindo dog, reduced glutathione.

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supporting

confidence: 92%

mentioning

confidence: 87%

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Relation between Erythrocyte Reduced Glutathione and Glutamate Concentrations in Korean Jindo Dogs with Erythrocytes Possessing Hereditary High Activity of Na-K-ATPase and a High Concentration of Potassium.

Yamato

Lee

Chang

et al. 1999

The Journal of Veterinary Medical Science

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“…In this study, the reduced values of MCH and MCHC indices were diagnosed in 75.7% and 40.5% dogs, respectively. Up to this point, HK phenotype was described in 10 out of 13 Japanese breeds and the frequency of its occurrence in the Akita breed is equal to 26.3% (Tanabe 2006) and 20% according to Fujise et al (1997) and Conrado et al (2014). This study did not evaluate K and Na ion concentrations, though it is known that Akita HK phenotype is distributed worldwide.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido

et al. 2017

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Microcytosis is observed in healthy Japanese breed dogs. The aim of the study was to evaluate the frequency and intensity of asymptomatic anisocytosis using a three-grade scale in Japanese dog breeds with special emphasis on the following indices: mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, and red blood cell distribution width. The retrospective study included analyses of blood morphology and blood smear for clinically healthy Japanese dog breeds Shiba, Akita, and Hokkaido aged from 6 months to 14 years, performed as a part of preventative care. A total of 74 dogs of both sexes were qualified for the study. The group included both neutered and non-neutered animals (Akita -17 females, 12 males, Shiba -24 females, 18 males, Hokkaido -2 females, 1 male). The blood smear revealed significant anisocytosis in 60.8% and mild anisocytosis in 28.4% of the tested dogs -89.2% in total. Microcytosis was reported for 25.7% of the tested Japanese breed dogs. Reduced mean cell haemoglobin and mean cell haemoglobin concentration were diagnosed in 75.7% and 40.5% of dogs, respectively. Red blood cell distribution width as an anisocytosis indicator exceeded the norm in 12% of the tested dogs. Compared to mixed breed dogs, the Japanese breeds had a reduced mean cell volume, mean cell haemoglobin concentration and significant anisocytosis in the blood smear as well as a higher red blood cell distribution width indicator. Veterinarians should consider these differences when interpreting the results of morphological blood tests.

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“…Elevated levels of these amino acids and GSH may account for the larger cell volume of HK RBCs. Interestingly, HK dogs have only been found in some Japanese and Korean breeds [3], and there have been no reports of HK dogs in other regions. The HK phenotype is inherited in an autosomal recessive mode and the LK phenotype is inherited in a dominant manner [8], though the gene responsible for these phenotypes is still unknown.…”

Section: Figmentioning

confidence: 99%

Aquaporin-1 Expression in Canine Peripheral Erythrocytes and Its Relation to Cell Volume

et al. 2011

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To evaluate the relationship between aquaporin-1 (AQP1) expression and the cell volume of red blood cells (RBCs), canine peripheral RBCs were separated according to specific gravity, and expression of the AQP1 protein on the membrane of RBCs was compared using anti-dog AQP1 polypeptide serum. Western blot analysis indicated that there was no significant difference in AQP1 expression between large and small cell fractions. In addition, the AQP1 expression of inherited high K/low Na RBCs which are known to be 20% larger than normal RBCs, was comparable to that of normal RBCs. These results suggest that AQP1, the major water channel in RBCs, does not determine the cell volume of peripheral canine RBCs.

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Incidence of Dogs Possessing Red Blood Cells with High K in Japan and East Asia.

Cited by 35 publications

References 13 publications

Relation between Erythrocyte Reduced Glutathione and Glutamate Concentrations in Korean Jindo Dogs with Erythrocytes Possessing Hereditary High Activity of Na-K-ATPase and a High Concentration of Potassium.

Relation between Erythrocyte Reduced Glutathione and Glutamate Concentrations in Korean Jindo Dogs with Erythrocytes Possessing Hereditary High Activity of Na-K-ATPase and a High Concentration of Potassium.

Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido

Aquaporin-1 Expression in Canine Peripheral Erythrocytes and Its Relation to Cell Volume

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