Incidence of diffuse lamellar keratitis after laser in situ keratomileusis associated with the IntraLase 15 kHz femtosecond laser and Moria M2 microkeratome

Abstract

Despite more intense postoperative steroid treatment, DLK seemed to occur more frequently after LASIK performed with the IntraLase 15 kHz femtosecond laser than after LASIK performed with the Moria M2 microkeratome.

Predictability of corneal flap thickness in laser in situ keratomileusis using a 200 kHz femtosecond laser

“…However, it seems to be associated with an increased incidence of interface haze. 18,19 In this study, there were no intraoperative or postoperative complications related to flap creation.…”

Laser in situ keratomileusis flap complications using mechanical microkeratome versus femtosecond laser: Retrospective comparison

“…The femtosecond laser emits a 1053 nm wavelength (infrared) light that produces microcavitation bubbles at a preset depth in the corneal stroma. 2,3 Because of its precision and more predictable flap depth, [3][4][5][6][7] this technology may offer several advantages over mechanical microkeratomes.…”

“…22 It has been hypothesized that an accumulation of gas bubbles and femtosecond laser energy could increase the inflammatory response in patiens who might be more susceptible to DLK. 2 Earlier models of the laser we used, especially the 15 kHz and earlier models, not only used higher energy levels but also had a pulse geometry that produced a larger width cut through the epithelium around the perimeter of the flap. This created a flap edge that was easier for the surgeon to visualize at the operating microscope but that resulted in more epithelial damage, a greater release of epithelial-derived cytokines, greater production of keratocyte-derived chemokines, and more inflammatory cell infiltration.…”

Management of pain with diclofenac after femtosecond-assisted laser in situ keratomileusis

“…The higher incidence of DLK may be associated with the use of the femtosecond laser compared with the incidence when a microkeratome is used. 21 This prospective randomized study assessed the effect of a single NSAID eyedrop to reduce early postoperative pain after LASIK with femtosecond laser flap creation. To our knowledge, this is the first published study assessing NSAID use for pain after femtosecond-assisted LASIK.…”