Incidence of Differentiated Thyroid Cancer by Socioeconomic Status and Urban Residence: Canada 1991–2006

Guay, Benoit; Johnson‐Obaseki, Stephanie; McDonald, James Ted; Connell, Chris; Corsten, Martin

doi:10.1089/thy.2013.0308

Cited by 45 publications

(43 citation statements)

References 7 publications

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“…3 A relationship between race, higher education level, urban residence, location around a metropolitan area, and higher socioeconomic status, which all allow better healthcare access, and a higher incidence of well-differentiated thyroid cancer has been found, even in healthcare systems with no barriers to access. 65,[99][100][101][102] In South Korea, the incidence of welldifferentiated thyroid cancer is 55% lower in the low-income group in comparison with high income. 103 Morris et al 104,105 found that 25% of the incidence can be explained by variables associated with better healthcare access.…”

Section: Economic and Medicolegal Issuesmentioning

confidence: 99%

“…Epidemiologic evidence from cancer registry analyses showed that the increase in well‐differentiated thyroid cancer was higher in developed countries (12/100 000 in Israel and 10/100 000 in the United States vs 1.5/100 000 in Uganda and 2.6/100 000 in Egypt) where access to the healthcare system is better . A relationship between race, higher education level, urban residence, location around a metropolitan area, and higher socioeconomic status, which all allow better healthcare access, and a higher incidence of well‐differentiated thyroid cancer has been found, even in healthcare systems with no barriers to access . In South Korea, the incidence of well‐differentiated thyroid cancer is 55% lower in the low‐income group in comparison with high income .…”

Section: Introductionmentioning

confidence: 99%

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Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis

et al. 2017

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There is an increasing incidence of well-differentiated thyroid cancer worldwide. Much of the increase is secondary to increased detection of small, low-risk tumors, with questionable clinical significance. This review addresses the factors that contribute to the increasing incidence and considers environmental, and patient-based and clinician-led influences. Articles addressing the causes of the increased incidence were critically reviewed. A complex interplay of environmental, medical, and social pressures has resulted in increased awareness of the thyroid disease risk, increased screening of thyroid cancers, and increased diagnosis of thyroid cancers. Although there is evidence to suggest that the true disease incidence may be changing slightly, most of the increase is related to factors that promote early diagnosis of low-risk lesions, which is resulting in a significant phenomenon of overdiagnosis. An improved understanding of these pressures at a global level will enable healthcare policymakers to react appropriately to this challenge in the future.

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Section: Economic and Medicolegal Issuesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis

et al. 2017

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“…Thyroid cancer is the endocrine malignancy 1 that, although stable until the 1990s, has progressively and greatly increased thereafter 2, 3 . The vast majority of the thyroid cancers originate from the follicular cell epithelium 1 , which includes papillary thyroid carcinoma (PTC) that accounts for approximately 80% of all thyroid malignancies 4 .…”

Section: Introductionmentioning

confidence: 99%

Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis

Goedert

Plaça²,

Fuziwara

et al. 2017

Sci Rep

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Papillary Thyroid Cancer (PTC) is an endocrine malignancy in which BRAFV600E oncogenic mutation induces the most aggressive phenotype. In this way, considering that lncRNAs are arising as key players in oncogenesis, it is of high interest the identification of BRAFV600E-associated long noncoding RNAs, which can provide possible candidates for secondary mechanisms of BRAF-induced malignancy in PTC. In this study, we identified differentially expressed lncRNAs correlated with BRAFV600E in PTC and, also, extended the cohort of paired normal and PTC samples to more accurately identify differentially expressed lncRNAs between these conditions. Indirectly validated targets of the differentially expressed lncRNAs in PTC compared to matched normal samples demonstrated an involvement in surface receptors responsible for signal transduction and cell adhesion, as well as, regulation of cell death, proliferation and apoptosis. Targets of BRAFV600E-correlated lncRNAs are mainly involved in calcium signaling pathway, ECM-receptor interaction and MAPK pathway. In summary, our study provides candidate lncRNAs that can be either used for future studies related to diagnosis/prognosis or as targets for PTC management.

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“…Thyroid cancer incidence, stable until the early 1990s, has continuously and dramatically increased thereafter (Howlader et al, 2013;Guay et al, 2014). During the same period, most cancers have decreased and no cancer has increased as much as thyroid cancer.…”

Section: Introductionmentioning

confidence: 99%

Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

Wang¹,

Wu²,

Chen³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Central lymph node metastasis(CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of this study was to define the pathohistologic risk grading based on surgical outcomes. Materials and Methods: Statistical analysis was performed to figure out the optimal cut-off values of size in preoperative ultrasound images for defining the risk of CLNM in papillary thyroid microcarcinoma. Receiver operating characteristic curves (ROC) studies were carried out to determine the cutoff value(s) for the predictor(s). All the patients were divided into two groups according to the above size and the clinic-pathological and immunohistochemical parameters were compared to determine the significance of findings. Results: The optimal cut-off value of tumor size to predict the risk of CLNM in papillary thyroid microcarcinoma was 0.575 cm (area under the curve 0.721) according to the ROC curves. Significant differences were observed on the multifocality, extrathyroidal extension and central lymph node metastasis between two groups which were divided according to the tumor size by the cutoff values. Patients in two groups showed different positive rate and intensity of Ki67. Conclusions: The size of PTMC in ultrasound images are helpful to predict the aggressiveness of the tumors, it could be an easy predictor for PTMC prognosis and assist us to choose treatment.

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Incidence of Differentiated Thyroid Cancer by Socioeconomic Status and Urban Residence: Canada 1991–2006

Abstract: Our study confirmed a dramatic increase in thyroid cancer incidence in Canada. Thyroid cancer incidence was significantly higher in higher InQs and in cities. These data support the theory that increased access to imaging is largely responsible for this increased incidence.

Cited by 45 publications

References 7 publications

Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis

Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis

Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis

Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

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