Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study

Rojo-Martínez, Gemma; Valdés, Sergio; Soriguer, Federico; Vendrell, Joan; Urrutia, Inés; Pérez, Vidal; Ortega, Emilio; Ocón, P.; Montanya, Eduard; Menéndez, Edelmiro; Lago-Sampedro, Ana; González-Frutos, T; Gomis, Ramón; Goday, Alberto; García‐Serrano, Sara; García‐Escobar, Eva; García, J.; Castell, Conxa; Badía-Guillén, Rocío; Aguilera–Venegas, Gabriel; Girbés, Juan; Gaztambide, Sonia; Franch-Nadal, Josep; Delgado, Elías; Chaves, Felipe Javier; Castaño, Luís; Calle-Pascual, Alfonso

doi:10.1038/s41598-020-59643-7

Cited by 87 publications

(83 citation statements)

References 38 publications

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“…The cumulative incidence rate of type 2 diabetes in 8.4 years of follow-up (7.5%) was similar to previous findings in Spain (6.5%) [24] and other European countries [25,26]. Importantly, the Kaplan-Meier curves show how the incidence rate of type 2 diabetes significantly increased with the SF quartiles, with results of 13.5%, 8.2%, 4.94% and 3.8% in the fourth, third, second and first quartiles, respectively.…”

Section: Discussionsupporting

confidence: 90%

Association between Iron Status and Incident Type 2 Diabetes: A Population-Based Cohort Study

et al. 2020

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Type 2 diabetes poses a major public health challenge. Here, we conducted a cohort study with a large sample size to determine the association of baseline serum ferritin (SF), a marker of iron status, with incident type 2 diabetes in primary healthcare patients in Catalonia, a western Mediterranean region. A total of 206,115 patients aged 35–75 years without diabetes and with available baseline SF measurements were eligible. The variables analyzed included sociodemographic characteristics, anthropometry, lifestyle, morbidity and iron status (SF, serum iron and hemoglobin). Incident type 2 diabetes during follow-up (2006–2016) was ascertained using the International Classification of Diseases, 10th edition. Cox proportional-hazards models adjusted for multiple baseline confounders/mediators were used to estimate hazard ratios (HRs). Over a median follow-up of 8.4 years, 12,371 new cases of type 2 diabetes were diagnosed, representing an incidence rate of 7.5 cases/1000 persons/year. Since at baseline, the median SF concentration was higher in subjects who developed type 2 diabetes (107.0 µg/L vs. 60.3 µg/L; p < 0.001), SF was considered an independent risk predictor for type 2 diabetes; the multivariable-adjusted HRs for incident type 2 diabetes across SF quartiles 1–4 were 1.00 (reference), 0.95 (95% CI = 0.85–1.06), 1.18 (95% CI = 1.65–1.31) and 1.51 (95% CI = 1.36–1.65), respectively. Our study suggested that higher baseline SF was significantly associated with an increased risk of new-onset type 2 diabetes in Catalan primary healthcare users, supporting the relevance of monitoring iron stores in order to improve the diagnosis and management of diabetes in clinical practice.

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Section: Discussionsupporting

confidence: 90%

Association between Iron Status and Incident Type 2 Diabetes: A Population-Based Cohort Study

et al. 2020

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“…Model selection was repeated for every combination of exposure variables (i.e., high-and medium-vs. low-exposure groups or continuous per 5-dB increase) and the outcome to ensure similar selections of covariates. Finally, we added two variables of age and sex to present the biological plausibility and one variable of a family history of diabetes to account for genetic effects 42,43 in creating the final model (i.e., Model 3). The step to select a priori important variables into the model can avoid overfitting 39,44 .…”

Section: Statistical Analysesmentioning

confidence: 99%

Occupational noise exposure and its association with incident hyperglycaemia: a retrospective cohort study

Chang

Liu

et al. 2020

Sci Rep

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noise pollution is reported to be associated with diabetes, but few studies have elucidated the associations between noise frequency characteristics. We aimed to evaluate the relationships between different noise frequency components and incident hyperglycaemia. An industry-based cohort of 905 volunteers was enrolled and followed up to 2012. Octave-band frequencies of workstation noise and individual noise levels were measured in 2012 to classify subjects' exposures retrospectively. We applied Cox regression models to estimate the relative risk (RR) of hyperglycaemia. An increased RR for hyperglycaemia of 1.80 (95% confidence interval [CI]: 1.04, 3.10) was found among subjects exposed to ≥ 85 A-weighted decibels (dBA) compared with those exposed to < 70 dBA. The highexposure groups at frequencies of 31.5, 63, 125, 250, 500, 1000, and 2000 Hz had a significantly higher risk of hyperglycaemia (all p values < 0.050) than the low-exposure groups. A 5-dB increase in noise frequencies at 31.5, 63, 125, 250, 500 Hz, and 1000 Hz was associated with an elevated risk of hyperglycaemia (all p values < 0.050), with the highest value of 1.27 (95% CI: 1.10, 1.47) at 31.5 Hz (p = 0.001). Occupational noise exposure may be associated with an increased incidence of hyperglycaemia, with the highest risk observed at 31.5 Hz. Growing numbers of field studies have reported an association between occupational noise exposure and cardiovascular disease (CVD) morbidity and mortality 1-10. In 2019, the World Health Organization (WHO) and the International Labour Organization (ILO) provided a joint methodology (WHO/ILO joint methodology) for estimating the work-related burden of CVD and injury due to workplace noise exposure 11. Noise exposure is regarded as an environmental stressor through direct (i.e., sleep disturbance) and indirect (i.e., annoyance) pathways that pose adverse health effects. Acute noise exposure may activate the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medulla axis to elevate the levels of stress hormones, including cortisol, catecholamine, adrenalin, and noradrenalin. Repeated and chronic stimuli may cause overproduction of stress hormones (e.g., cortisol) that increase the levels of fatty acids and glucose to partially restore homeostasis. In addition, catecholamines also boost the energy supply by breaking down triacylglycerol. Such increases in stress hormones may lead to pathophysiologic alterations in blood pressure, blood lipids, blood viscosity, and blood glucose, which promote the development of hypertension, arteriosclerosis, and CVD 12-14. Because the overproduction of cortisol may inhibit pancreatic insulin secretion and reduce insulin sensitivity in the liver, skeletal muscles, and adipose tissue 14 , it is plausible that long-term noise exposure may produce adverse changes in blood glucose. Noise pollution has been reported to be associated with diabetes in many animal and environmental epidemiological studies; however, few studies have elucidated the relationship between noise fre...

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“…According to epidemiological studies, 415 million people in the world are affected by T2DM [3], but this could be an underestimation, since, according to the International Diabetes Federation, there are 46.5% of people with T2DM still undiagnosed. In Spain, one of the main causes of this large number of people with T2DM is the increasingly aged demographic structure, since this is considered a risk factor for the disease [4].…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of a Whole Body Vibration Session on the Vibration Perception Threshold in Patients with Type 2 Diabetes Mellitus

Domínguez‐Muñoz

Hernández-Mocholí

Villafaina

et al. 2020

IJERPH

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Background: Type 2 Diabetes Mellitus (T2DM) is a chronic disease that affects millions of people, and according to the International Diabetes Federation, 46.5% of people have undiagnosed diabetes. One of the most common complications of diabetes mellitus is loss of peripheral sensation. Whole Body Vibration (WBV) is a therapy, and it would be interesting to know if it can be considered as a training method to improve the Vibration Perception Threshold (VPT). The aim of the study is to verify whether there are really acute effects on the VPT after a WBV training session in people with T2DM. Methods: Ninety people with T2DM (56 men and 34 women) were randomly allocated to two groups: the WBV group and the placebo group. The ninety subjects went through a VPT training test before receiving the assigned intervention, and they performed the VPT test using the Vibratron II device. Results: After one session of WBV, an increase of the VPT in the WBV group was found, with respect to the placebo group. Conclusions: Vibration perception threshold is increased after a WBV training session in people with T2DM, compared to a placebo group.

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Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study

Cited by 87 publications

References 38 publications

Association between Iron Status and Incident Type 2 Diabetes: A Population-Based Cohort Study

Association between Iron Status and Incident Type 2 Diabetes: A Population-Based Cohort Study

Occupational noise exposure and its association with incident hyperglycaemia: a retrospective cohort study

Acute Effects of a Whole Body Vibration Session on the Vibration Perception Threshold in Patients with Type 2 Diabetes Mellitus

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