Incidence of dementia in elderly Latin Americans: Results of the Maracaibo Aging Study

Maestre, Gladys E.; Mena, Luis J.; Melgarejo, Jesús D.; Aguirre–Acevedo, Daniel Camilo; Pino-Ramirez, Gloria; Urribarri, Milady; Chacón, Inara J.; Chávez, Carlos; Falque-Madrid, Luis; Gaona, Ciro; Terwilliger, Joseph D.; Lee, Joseph H.; Scarmeas, Nikolaos

doi:10.1016/j.jalz.2017.06.2636

Cited by 31 publications

(38 citation statements)

References 48 publications

(56 reference statements)

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“…Meningkatnya jumlah demensia berdampak pada perubahan perilaku lansia. Dampak yang terjadi pada lansia dengan demensia adalah munculnya beberapa gangguan yang terjadi, antara lain, pemenuhan aktivitas hidup sehari-hari secara mandiri, dan munculnya ketidakstabilan emosi (Maestre et al, 2018).…”

Section: Latar Belakangunclassified

Pengaruh Mindfulness Terhadap Caregiver Burden Lansia Dengan Demensia Di Panti Wreda

Triyono

Dwidiyanti

Widyastuti

2018

jikk

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Data yang diperoleh pada bulan November 2017 pada saat dilakukan screening didapatkan data bahwa terdapat 35 Caregiver mengalami burden dengan kategori ringan sampai berat, yang terdiri dari 10 orang mempunyai burden ringan, 23 orang burden sedang dan 1 orang mempunyai burden berat. Kemudian pada saat dilakukan wawancara menyatakan bahwa caregiver merasa kelelahan karena kurang lebih 8 jam merawat lansia dengan demensia, Caregiver juga sering menahan emosi terkait dengan tingkah laku lansia yang sulit diatur. Metode penelitian yang digunakan dalam penelitian ini adalah "quasy experimental pre-post test with control group, jumlah sampel 34 orang yang diambil dengan purposive sampling, intervensi yang diberikan melalui intervensi mindfulness. Pada kelas intervensi, terdapat perbedaan tingkat caregiver burden secara signifikan antara pre-test dan post-test (p-value=0,000<α=0,05). Dari hasil tersebut maka pemberian perlakuan berpengaruh signifikan dalam menurunkan tingkat Caregiver Burden. Dilihat secara deskriptif, rata-rata tingkat caregiver Burden pada kedua kelas kontrol baik pre-test maupun post-test berada pada level sedang. Intervensi mindfulness dapat membantu permasalahan caregiver yang merawat lansia dengan demensia, emosional dari caregiver, khususnya burden, ekonomi, burden sosial, burden psikologis. Mindfulness lebih efektif ketika caregiver aktif melakukan latihan secara kontinu sehingga tingkat caregiver burden dapat berkurang

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Section: Latar Belakangunclassified

Pengaruh Mindfulness Terhadap Caregiver Burden Lansia Dengan Demensia Di Panti Wreda

Triyono

Dwidiyanti

Widyastuti

2018

jikk

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“…Dementia of the Alzheimer's type (DAT) affects Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites [1,2]. Despite evidence that intensive BP control helps prevent cognitive decline and dementia [3], and that hypertension is by far the dominant reversible risk factor for AD, risk stratification for AD among hypertensives is still controversial [4], especially among minority populations.…”

Section: Introductionmentioning

confidence: 99%

Nighttime Blood Pressure Interacts with APOE Genotype to Increase the Risk of Incident Dementia of the Alzheimer’s Type in Hispanics

Melgarejo

Aguirre–Acevedo

Gaona

et al. 2020

JAD

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Background: Dementia of the Alzheimer’s type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE-ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics. Objective: To investigate the association of APOE-ɛ4 and BP levels, measures with 24-h ambulatory BP monitoring, with incidence of DAT in an elderly cohort of Hispanics. Methods: 1,320 participants from the Maracaibo Aging Study, free of dementia at the baseline, and with ambulatory BP measurements and APOE genotype available were included. Adjusted Cox proportional models were performed to examine 1) the incidence of DAT and 2) the relationship between BP levels and DAT according to APOE genotypes. Models were adjusted by competing risk of death before the onset of DAT. Model performance was assessed by likelihood test. Results: The average follow-up time was 5.3 years. DAT incidence was 5.8 per 1000 person-year. APOE-ɛ4 carriers had a higher risk of DAT. In unadjusted analyses, conventional, 24-h, and nighttime systolic BP levels were significantly higher in participants who developed DAT and of APOE-ɛ4 carriers (p < 0.05). After adjustment for competing risks, only higher nighttime systolic BP was associated with DAT incidence, but only among subjects carrying APOE-ɛ4. Conclusion: In this Hispanic population, both APOE-ɛ4 genotype and assessment of nocturnal systolic BP (rather than diurnal or office BP) were necessary to estimate DAT risk.

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“…Approximately 20% of elderly individuals would develop dementia after the diagnosed of MCI [5,6]. Interestingly, although Hispanics from Latin America (LA) have almost two-fold higher risk of developing Late-Onset Alzheimer's disease (LOAD) than white North Americans [7,8], the rates of MCI reported in individuals from the United States (US) [9,10] are particularly higher than Hispanics in LA (20% vs. <10%) [11]. This could be attributed to the fact that LA regions, as part of developing countries, fail to diagnose individuals with MCI and/or to identify individuals at high risk for dementia.…”

Section: Introductionmentioning

confidence: 99%

Differential Methylation in APOE Genes (Chr19; exon four; from 44,909,188 to 44,909,373) and Increased Apolipoprotein E Plasmatic Levels in Subjects with Mild Cognitive Impairment”

Mancera-Páez¹,

Estrada-Orozco²,

Mahecha³

et al. 2019

Preprint

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Background: Biomarkers are essential for identification of individuals at high risk of mild cognitive impairment (MCI) for potential prevention of dementia. We investigated DNA methylation in the ApoE gene and plasmatic apolipoprotein E (ApoE) levels as MCI biomarkers in Colombian subjects with MCI and controls. Methods: 100 participants were included (71% women, average age, 70 yrs., range 43-91). MCI was diagnosed by neuropsychological testing, medical and social history, activities of daily living, cognitive symptoms and neuroimaging. Multivariate logistic regression models adjusted by age and gender were performed to examine the risk association of MCI with plasma ApoE and APOE methylation Results: MCI was diagnosed in 41 subjects (average age, 66.5±9.6 yrs.) and compared with 59 controls. Elevated plasma ApoE and APOE methylation of CpGs 165, 190, and 198 were risk factors for MCI (P<0.05). Higher CpG-227 methylation correlated with lower risk for MCI (P=0.002). Only CpG-227 was significantly correlated with plasmatic ApoE levels (correlation coefficient=-0.665; P=0.008). Conclusion: Differential APOE methylation and increased plasma ApoE levels were correlated with MCI. These epigenetic patterns can be used as potential biomarkers to identify early stages of MCI.

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Incidence of dementia in elderly Latin Americans: Results of the Maracaibo Aging Study

Abstract: Among Maracaibo Aging Study participants younger than 65 years, the incidence of dementia was higher than that of US Whites. Among individuals older than 65 years, the incidence was comparable to the mean of previous incidence estimates for other populations worldwide.

Cited by 31 publications

References 48 publications

Pengaruh Mindfulness Terhadap Caregiver Burden Lansia Dengan Demensia Di Panti Wreda

Pengaruh Mindfulness Terhadap Caregiver Burden Lansia Dengan Demensia Di Panti Wreda

Nighttime Blood Pressure Interacts with APOE Genotype to Increase the Risk of Incident Dementia of the Alzheimer’s Type in Hispanics

Differential Methylation in APOE Genes (Chr19; exon four; from 44,909,188 to 44,909,373) and Increased Apolipoprotein E Plasmatic Levels in Subjects with Mild Cognitive Impairment”

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