Incidence of dementia and subtypes: A cohort study in four regions in China

Yuan, Jing; Zhang, Zhenxin; Wen, Hongbo; Xia, Hong; Hong, Zhen; Qu, Qing; Tang, Miaoling; Wu, Jixing; Xu, Qun; Li, Hui; Cummings, Jeffrey L.

doi:10.1016/j.jalz.2015.02.011

Cited by 58 publications

(44 citation statements)

References 36 publications

(57 reference statements)

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“…According to the American College of Sport Medicine (ACSM) [3], ageing is associated with some physiologic changes that modify physical and mental health among other factors. In addition, becoming older has some effects on individuals, such as an acceleration in the decline of aerobic capacity and strength [4], memory deterioration [5], decline of motivation and increase of negative emotions [6] or an increment on the prevalence of cognitive impairment and dementia [7,8].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A Systematic Review of the Literature Regarding Physical, Cognitive and Emotional Outcomes in Older Adults Practitioners of Physical Exercise

Araque-Martínez¹,

Artés-Rodríguez²,

Casimiro-Andújar³

et al. 2020

Preprint

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Background: This systematic review provides an overview about those papers with a specific physical exercise intervention aimed to improve physical, cognitive and/or emotional outcomes in healthy older people aged 60 or over. Studies with no intervention whose sample were active healthy older adults were also included.Methods: An exhaustive literature search was done through two databases, including studies from January 2000 to July 2020. Results: Of the 2006 identified records, 66 met the inclusion criteria and were selected. Results from the review showed a wide variety of older adults and lengths of the interventions, from five weeks (the shortest one) to five years. Aerobic exercise, either isolated or combined with strength performance, was also the most common type of exercise recognized in this systematic review.Conclusions: Findings also suggest that the number of studies with all, physical, cognitive and emotional outcomes have been increasing during recent years in healthy older adults.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A Systematic Review of the Literature Regarding Physical, Cognitive and Emotional Outcomes in Older Adults Practitioners of Physical Exercise

Araque-Martínez¹,

Artés-Rodríguez²,

Casimiro-Andújar³

et al. 2020

Preprint

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“…Alzheimer's disease contributes to more than 50% of the total cases. Around the world, about 46 million people had some kind of dementia in 2015 (GBD 2015 Disease and Injury Incidence and Prevalence Collaborators 2016), and 15 to 20% of them were in China (Yuan et al 2016a). Dementia can not be cured in most cases, which causes long-term harm to individuals, families and society.…”

Section: Introductionmentioning

confidence: 99%

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study

Wang

Liu

et al. 2018

Tohoku J. Exp. Med.

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Mild cognitive impairment (MCI) is the prophase of dementia. MCI patients have a high risk of developing dementia. Relatively low serum albumin levels are associated with the development of several geriatric diseases, including stroke and poor cognitive performance. However, the potential relationship between serum albumin levels and MCI risk has not been fully elucidated. In the present study, we explored this relationship to increase our understanding of the pathogenesis of MCI, the finding of which may provide new ideas for the controlling of dementia. A total of 1,800 subjects who had normal cognitive function at their first health examinations (seven years ago) were retrospectively analyzed from a health database in Tianjin Medical University General Hospital. They were over 60 years old at baseline, and the follow-up period was 7 years. At the time of data collection (seven years after), 196 subjects suffered from MCI, diagnosed by symptoms and Mini-Mental State Examination. The remaining 1,604 subjects were still cognitively normal. Multivariate COX regression analysis showed that relatively low serum albumin levels at baseline (< 40.5 g/L) were associated with the increased risk of MCI (HR: 2.18, 95% CI: 1.67-2.82). Moreover, the effect of low serum albumin on the risk of MCI was further enhanced among the subjects with hypertension, diabetes, hyperlipemia, cardiovascular disease, cerebrovascular disease, high serum levels of C-reactive protein, or relatively low levels of uric acid or total bilirubin. In conclusion, relatively low serum concentrations of albumin may be an independent risk factor for MCI in elderly.

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“…VaD is the second most common form of dementia after Alzheimer’s disease (AD) and places an enormous burden on society (Erkinjuntti, 1999). In China, it is estimated that the crude incidence in persons ≥65 years was 3.1/1000 person-years for VaD (Yuan et al, 2016). Subcortical vascular dementia (SVaD), a small vessel disease (SVD), constitutes approximately half of VaD cases (Yoshitake et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Characterizing Brain Iron Deposition in Patients with Subcortical Vascular Mild Cognitive Impairment Using Quantitative Susceptibility Mapping: A Potential Biomarker

Sun

Han

et al. 2017

Front. Aging Neurosci.

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The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correlation between brain iron deposition and the severity of cognitive impairment as indicated by z-scores. We recruited 20 subcortical ischemic vascular disease (SIVD) patients who fulfilled the criteria for svMCI. The control group comprised 19 SIVD patients without cognitive impairment. The SIVD and control groups were matched based on age, gender, and years of education. Both groups underwent QSM using a 3.0T MRI system. Susceptibility maps were reconstructed from in vivo data, which were acquired with a three-dimensional spoiled gradient recalled sequence. Then, regions of interest were drawn manually on the map of each subject. The inter-group differences of susceptibility values were explored in deep gray matter nuclei, including the bilateral pulvinar nucleus of the thalamus, head of caudate nucleus, globus pallidus, putamen, hippocampus, substantia nigra, and red nucleus. The correlations between regional iron deposition and composite z-score, memory z-score, language z-score, attention-executive z-score and visuospatial z-score were assessed using partial correlation analysis, with patient age and gender as covariates. Compared with the control, the svMCI group had elevated susceptibility values within the bilateral hippocampus and right putamen. Furthermore, the susceptibility value in the right hippocampus was negatively correlated with memory z-score and positively correlated with language z-score. The susceptibility value in the right putamen was negatively correlated with attention-executive z-score in the svMCI group. However, composite z-score were unrelated to susceptibility values. Our results suggest that brain iron deposition has clinical relevance as a biomarker for cognition. In addition, our results highlight the importance of iron deposition in understanding svMCI-associated cognitive deficits in addition to conventional MRI markers.

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Incidence of dementia and subtypes: A cohort study in four regions in China

Abstract: The incidence of dementia in Chinese population is comparable with that in Europe and United States.

Cited by 58 publications

References 36 publications

WITHDRAWN: A Systematic Review of the Literature Regarding Physical, Cognitive and Emotional Outcomes in Older Adults Practitioners of Physical Exercise

WITHDRAWN: A Systematic Review of the Literature Regarding Physical, Cognitive and Emotional Outcomes in Older Adults Practitioners of Physical Exercise

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study

Characterizing Brain Iron Deposition in Patients with Subcortical Vascular Mild Cognitive Impairment Using Quantitative Susceptibility Mapping: A Potential Biomarker

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