Incidence of deep venous thrombosis: a comparison of two Australian hospitals

Abstract

In this retrospective observational study, we observed that principal and comorbid diagnoses of deep venous thrombosis (DVT) occurred at a rate of 1.02 and 4.86 per 1000 admissions. Principal DVT diagnosis admissions were more common in the public hospital (1.29 vs 0.57 per 1000; P < 0.001), while the private hospital had nearly three times the admissions with comorbid DVT (2.99 vs 8.23 per 1000; P < 0.001). In-hospital mortality was uncommon (0.2% and 1.6% for principal and comorbid DVT diagnoses, respectively), and this did not differ significantly between the two hospitals.

TGF-β1 and Serpine 1 expression changes in traumatic deep vein thrombosis

“…Gene expression levels were quantified relative to the expression of GAPDH using an optimized comparative Ct (ΔCt) value method (Schmittgen and Livak, 2008). Bioinformatic analysis on TGF-β1 and Serpine 1 signaling pathways was performed through the KEGG pathway database (Shiraev et al, 2014). Table 1.…”

Incidence of pulmonary embolism: a comparison of two Australian hospitals

“…There are several limitations of this study, which have been outlined previously . One weakness that must be considered is the lack of quantification of illness severity (e.g.…”

“…Using the International Classification of Diseases (10th revision) codes I26.0 ( pulmonary embolism with acute cor pulmonale ) and I26.9 ( pulmonary embolism without acute cor pulmonale ), we extracted data on all separations (with the assumption that one separation, or discharge, equals one admission – and henceforth the word ‘admission’ will be used for ‘separation’) for PE between 2001/2002 and 2010/2011, and standardised them into a rate per 1000 admissions. Methods and statistical analyses have been described previously . Ethics approval for the study was obtained from the Human Research Ethics Committee of the University of Notre Dame, Australia.…”

“…While patients at the public hospital suffered a quadrupled and doubled in‐hospital mortality rate for principal and secondary diagnosis of PE, respectively, when compared with the private, no significant difference in mortality rate between the hospitals was found after correcting for other factors. The risk of overdiagnosis and subsequent treatment of pulmonary emboli has been discussed in previous studies by this group . While the use of D‐dimer has been advocated to prevent overuse of CT in the diagnosis of PE, this has obvious limitations in patients with acute comorbidities.…”

“…5 While there are several preventive strategies that can be used by hospital staff to minimise the likelihood of a patient developing VTE, 6 implementation of these remains poor. 7 Hospital admissions due to PE have increased markedly in the USA, Europe, the United Kingdom and China, [8][9][10][11] with a simultaneous decrease in mortality in these countries, [11][12][13] the reasons for which remain unclear. 8 We sought to assess patterns of distribution of PE within and between two hospitals (one public, one private) in Sydney, Australia, examining trends over time.…”