Incidence of congenital malformation in 2 major hospitals in Rivers state of Nigeria from 1990 to 2003

Ekanem, B.E.; Bassey, IE; Oe, Mesembe; Ma, Eluwa; Mb, Ekong

doi:10.26719/2011.17.9.701

Cited by 20 publications

(24 citation statements)

References 12 publications

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“…The explanation for this difference is not very clear as consanguinity which has been associated with congenital abnormalities is common in Northern Nigeria and the Southern part of Nigeria where the other study 12 was done is an oil producing area with a higher risk of environmental pollution; thus a higher incidence would have been expected in these areas. Both studies were however done over a decade ago.…”

Section: Discussionmentioning

confidence: 74%

“…Neural tube defects were also the most common abnormality in some earlier studies. 4,12 The system with the highest frequency of abnormalities in some other Nigerian studies was the gastrointestinal. 5,16 This may be due to difference in the classification of disorders; the current study used the ICD-10 system which is recommended for uniformity in disease classification while other studies did not state the method used in the classification.…”

Section: Discussionmentioning

confidence: 99%

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An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

Fajolu¹,

Ezenwa²,

Akintan³

et al. 2016

Nig. J. Paed.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

Fajolu¹,

Ezenwa²,

Akintan³

et al. 2016

Nig. J. Paed.

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“…These figures are extremely high, when compared with the finding from previous work that was conducted in the same hospital. The study reviewed cases of obvious major birth defects from 1990 to 2003 9. The prevalence of birth defects in that study was 4.0 per 1,000 live births.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and pattern of birth defects in a tertiary health facility in the Niger Delta area of Nigeria

Abbey¹,

Oloyede²,

Bassey³

et al. 2017

IJWH

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ObjectiveTo ascertain the prevalence and pattern of congenital abnormalities that are peculiar to the Niger Delta area of Nigeria.MethodsThis is a descriptive retrospective cross-sectional study. It involved data from the labor ward and neonatal birth registers of the University of Port Harcourt Teaching Hospital on the total number of births and the babies that were delivered with major birth defects between August 2011 and December 2014. We also conducted a statistical comparison of the prevalence of congenital abnormalities in the Niger Delta with that in other regions of Nigeria and the developed world of Europe.ResultsOut of the 7,670 deliveries that occurred, 159 maternities had babies with major birth defects giving a prevalence of 20.73 cases per 1,000 live births. This figure is far more than that which was obtained in other regions of Nigeria −4.15:cases per 1,000 live births in the South East (P<0.001), 15.84:1,000 in the South West (P<0.01), and 5.51:1,000 in the North East (P<0.001). Eighty-five (53.46%) of the defects occurred in 1,681 unbooked patients, while 74 (46.54%) happened in 5,989 booked maternities (P<0.001). The predominant abnormalities were those of the central nervous system at 27.0%, gastrointestinal system 11.95%, cardiovascular system 10.69%, anterior abdominal wall 8.18%, skeleton 6.29%, and chromosomal abnormalities at 5.66%.ConclusionThe prevalence of major birth defects at the University of Port Harcourt Teaching Hospital was 20.73 cases per 1,000 live births and it was more in the unbooked than the booked maternities. All body systems were affected with those of the central nervous system predominating at 27.0% of the total diagnosed defects.

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“…[8][9][10] Differently, other studies report higher frequency of CAs of the cardiovascular system. 5,[11][12][13] On the other hand, the higher frequency of CNS has been reported in several studies in Iran, 14 Japan, 15 Pakistan, 16,17 China, 18 Nigeria, 19 Tanzania, 20 and India. [8][9][10] The etiology of CNS anomalies is multifactor and involves complex interactions between genetic and environmental factors, constituting one of the most common congenital defects.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

Moraes

Melo

Amaral

2020

Rev Bras Ginecol Obstet

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Objective To evaluate the frequency of structural congenital anomalies (CAs) in the midwest of Brazil and its association with maternal risk factors. Methods This was a prospective, observational, case-control study based on a hospital population. Pregnant women attended at a fetal medicine service in Brazil were analyzed in the period from October 2014 to February 2016.A total of 357 pregnant women were included, 223 of whom had fetuses with structural anomalies (group case), and 134 of whom had structurally normal fetuses (control group). The clinical history was made previous to prenatal consultation, and the diagnosis of the structural CA was performed through ultrasound. Results A frequency of 64.27% (n = 223) of pregnant women with fetuses with structural anomalies was observed. The most frequent structural CAs were those of the central nervous system (30.94%), followed by anomalies of the genitourinary system (23.80%), and, finally, by multiple CAs (16.60%). The background of previous children with CAs (odds ratio [OR]: 3.85; p = 0.022), family history (OR: 6.03; p = < 0.001), and consanguinity between the progenitors (OR: 4.43; p = 0.034) influenced the occurrence of structural CA. Conclusion The most frequent CAs are those of the central nervous system, followed by those of the genitourinary system, and then multiple anomalies. The maternal risk factors that may have influenced the occurrence of structural CA were previous children with CA, family history, and consanguinity among the parents.

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Incidence of congenital malformation in 2 major hospitals in Rivers state of Nigeria from 1990 to 2003

Cited by 20 publications

References 12 publications

An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

Prevalence and pattern of birth defects in a tertiary health facility in the Niger Delta area of Nigeria

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

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