Incidence of congenital idiopathic clubfoot in the Netherlands

Besselaar, A. T.; Kamp, Maud C; Reijman, Max; Steen, Marieke van der

doi:10.1097/bpb.0000000000000525

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…The first US was performed before the start of treatment if possible (20 clubfeet in 13 children) or else at one of the first plaster changes (10 clubfeet in seven children). Ultrasound investigations were then repeated at the ages of 3,6,12,18,24,30,36,42, and 48 months. The contralateral normal feet in unilateral cases were examined on the same occasions as the clubfeet.…”

Section: Methodsmentioning

confidence: 99%

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A four-year clinical and sonographic longitudinal follow-up of clubfeet treated according to Ponseti with normal references

Johansson

Aurell

Romanus

2023

Journal of Children's Orthopaedics

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Purpose: To follow children with a clubfoot by ultrasonography during the entire treatment period up to 4 years and compare with controls. Method: Thirty clubfeet in 20 children treated using the Ponseti method and 29 controls were followed by repeated ultrasonography investigations from neonates to the age of 4 years. The previously established coronal medial and lateral, sagittal dorsal and posterior projections were used. Changes over time, correlations to the Diméglio score, and the course of treatment were studied. Results: The medial malleolus–navicular distance was shorter, while the talar tangent–navicular distance and the talo-navicular angle were larger in clubfeet than in controls even after the initial correction. The healthy feet in unilateral cases did not differ significantly from the controls. The range of motion in the talo-navicular joint was approximately 20° less in clubfeet than in controls during the first four years of life. The medial malleolus–navicular distance ( r = –0.58) and the talo-navicular angle ( r = 0.66) at the first ultrasonography showed the highest correlation to the number of casts needed to correct the deformities. Conclusion: Ultrasonography can be used to evaluate the initial degree of deformities in clubfeet and to follow the progress of the treatment and growth. Ultrasonography showed a clear difference between clubfeet and controls during the first four years of life. Although it was not possible to define specific limit values as benchmarks in the treatment, dynamic ultrasonography can provide valuable support in the decision-making process when complementary treatment may be needed. Level of evidence: III

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Section: Methodsmentioning

confidence: 99%

“…Clubfoot is a common congenital deformity with a geographical variation in prevalence from 1 to 6 out of 1000 live births. [1][2][3][4] The non-surgical Ponseti method is currently widely accepted as the treatment of choice. 1 The treatment starts with manipulations and castings (the correction phase).…”

Section: Introductionmentioning

confidence: 99%

A four-year clinical and sonographic longitudinal follow-up of clubfeet treated according to Ponseti with normal references

Johansson

Aurell

Romanus

2023

Journal of Children's Orthopaedics

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“…Congenital clubfoot (CCF), or talipes equinovarus, is one of the most common congenital malformations that seriously compromises child health, occurring in approximately one of every thousand live births [ 1 , 2 ]. Because clubfoot is a heterogeneous, multifactorial disorder, its exact etiology has not yet been fully elucidated [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

All-trans-retinoic acid suppresses rat embryo hindlimb bud mesenchymal chondrogenesis by modulating HoxD9 expression

Hong

Xie

et al. 2021

Bioengineered

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In vertebrates, 5 -Hoxd genes (Hoxd9), which are expressed in the hindlimb bud mesenchyme, participate in limb growth and patterning in early embryonic development. In the present study, We investigated the mechanisms by which ATRA regulates cultured E12.5 rat embryo hindlimb bud mesenchymal cells (rEHBMCs). Following exposure to ATRA over 24 h, mRNA and protein expression levels of HoxD9 were evaluated by reverse transcription-polymerase chain reaction (RT-PCR), quantitative real-time PCR (qPCR), and western blotting. Flow cytometry was used to detect apoptosis. ATRA inhibited the condensation and proliferation, and promoted the apoptosis rate of the rEHBMCs in a dose-dependent manner. Sox9 and Col2a1 in rEHBMCs were downregulated by ATRA in a dose-dependent manner at both mRNA and protein levels. Similarly, HoxD9 was downregulated by ATRA in a dose-dependent manner, in parallel with the cartilagespecific molecules Sox9 and Col2a1. Both qPCR and western blotting showed that both Shh and Gli3 were downregulated. Overexpression of HoxD9 reversed the effects of ATRA. These results demonstrate that ATRA suppresses chondrogenesis in rEHBMCs by inhibiting the expression of HoxD9 and its downstream protein targets, including Sox9 and Col2a1. This effect may also be correlated with inhibition of the Shh-Gli3 signaling pathway.

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“…Idiopathic clubfoot or talipes equinovarus is a well-known deformity of the lower extremity in children. The disorder is characterized by a 3-dimensional foot deformity with 4 components: cavus, equinus, varus, and adductus 1,2. If left untreated, a clubfoot will lead to deformity, functional disability, and pain.…”

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confidence: 99%

Participation and Motor Abilities in Children Aged 5 to 9 Years With Idiopathic Clubfeet After Treatment With the Ponseti Method

Dijk

Besselaar

Grin

et al. 2022

Journal of Pediatric Orthopaedics

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† § and on behalf of the Dutch Clubfoot CentresBackground: Functioning in children consists of different aspects, including their ability to execute activities and participate in life situations. Several studies on children with clubfeet showed limited motor abilities and walking capacity compared with healthy control children, while other studies showed comparable athletic abilities and gross motor development. Although participation in activities of daily life plays an important role in the development of children, this has not yet been investigated in children with clubfeet. The study aims to determine the level of parents' perceived motor ability and participation in Ponsetitreated children with clubfeet compared with age-matched healthy controls. Methods: Parents of children aged 5 to 9 years with and without idiopathic Ponseti-treated clubfeet were asked to complete an online questionnaire about their child's motor abilities and participation level using the Dutch version of the Assessment of Life Habits for Children (LIFE-H) version 3 to assess participation and the Dutch Movement Assessment Battery for Children-2 Checklist (MABC-2 Checklist) to assess motor abilities. Statistical analysis focused on differences between groups and the relationship between motor abilities and level of participation.Results: Questionnaires of 86 children with clubfeet (mean age 7.1, 73% boys) and 62 controls (age 6.7, 53% boys) were analyzed. Despite a large variation, results showed no significant differences between groups on the total scores of the LIFE-H and the MABC-2 Checklist. Children with clubfeet, however, scored lower on Mobility and better on the categories Communication and Responsibility of the LIFE-H. Furthermore, children with clubfeet showed lower scores on the MABC-2 Checklist subscale "movement in a static and/or predictable environment." High levels of the parents' perceived participation correlate with good results, as perceived by the parents, in motor ability. Conclusions: Although differences on some aspects of motor ability and participation existed, children with clubfeet in general showed high levels of parents' perceived motor ability and participation. High levels of participation correlated with good results in motor ability. Level of Evidence: Level II.

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Incidence of congenital idiopathic clubfoot in the Netherlands

Cited by 13 publications

References 20 publications

A four-year clinical and sonographic longitudinal follow-up of clubfeet treated according to Ponseti with normal references

A four-year clinical and sonographic longitudinal follow-up of clubfeet treated according to Ponseti with normal references

All-trans-retinoic acid suppresses rat embryo hindlimb bud mesenchymal chondrogenesis by modulating HoxD9 expression

Participation and Motor Abilities in Children Aged 5 to 9 Years With Idiopathic Clubfeet After Treatment With the Ponseti Method

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