Incidence of Clinically Important Biphasic Reactions in Emergency Department Patients With Allergic Reactions or Anaphylaxis

Biphasic reactions in patients with anaphylaxis treated with corticosteroids

“…20 In this study, epinephrine was administered to 58.1% of patients, which was higher than in previous studies where it ranged from 12% to 54%. 5,16,17,21,22 Several studies have reported that delayed administration of epinephrine could relate to the occurrence of biphasic reactions. 10,14 However, in the present study, no association was observed between the timing of epinephrine and the occurrence of biphasic reactions (P ¼ .52; Table 2).…”

“…4 A biphasic reaction is a recurrent reaction or the appearance of new signs or symptoms after the initial allergy-related presentation without further exposure to the causative agent. 5 It can be more severe than the first presentation and corticosteroids are often used to prevent it. 6 According to current guidelines, patients with anaphylaxis are kept under observation in the emergency department (ED) for at least 6 hours.…”

Corticosteroids in management of anaphylaxis; a systematic review of evidence

“…There is some evidence suggesting that the length of hospital stay tends to be shorter in those treated with corticosteroids for anaphylaxis (60). However, it has not been found to reduce the revisits to the emergency department with anaphylaxis or other unrelated causes (61). None of the human studies had sufficient data to comment on the response Biphasic anaphylactic reactions were reported in approximately 2.2% to 8.7% of patients reporting to emergency departments (56,57).…”

“…However, three other studies have not found a significant difference in emergency treatment Most cases of anaphylaxis resolved after initial treatment. One to 20% will develop a biphasic reaction, a delayed recurrence of illness occurring hours after improvement of the symptoms (59,61,69). There are multiple factors that have been described to be associated with biphasic reactions including under-treatment and delay in treatment (58,59).…”

Anafilaksja jako ogólnoświatowy problem społeczny – wskazówki dla lekarzy POZ i pacjentów

“…Według danych z dobrze udokumentowanych badań, częstość reakcji dwufazowej nie przekracza 4,5% przypadków anafilaksji. Jej wystąpienie nie łączy się z większym ryzykiem śmiertelności, dotyczy głównie chorych po przebytej anafilaksji, chorych z wymiotami lub skurczem oskrzeli w trakcie reakcji [23][24][25]. Po podaniu adrenaliny postępowanie tzw.…”