“…In most studies, endoscopy was read locally; central reading was performed in only 5 studies. 20,25,26,30,41 For studies comparing risk of clinical relapse in patients with histologic remission to those with persistent histologic activity, the majority used the MES for assessing endoscopic healing/remission (14/20 studies), and 15/20 used standardized indices for assessing histologic activity (Geboes' score, 7 studies; 16,17,21,32,35,36,39 Matts classification, 3 studies; 22,34,41 Harpaz index, 2 studies; 27,31 Riley score, 2 studies; 13,20 Nancy index, 1 study). 42 Study-level risk of bias assessment is summarized in Supplementary Table 2.…”