Incidence of chronic immune-mediated inflammatory diseases after diagnosis with Kawasaki disease: a population-based cohort study

Fung, Stephen; Webster, Richard; Kuenzig, M Ellen; Knight, Braden; Batthish, Michelle; Robinson, Cal; Chanchlani, Rahul; Benchimol, Eric I; Jiménez-Rivera, Carolina

doi:10.1093/rheumatology/keab680

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is debatable whether KD is postinfectious hyperinflammation, autoinflammatory, or autoimmune disorders [ 29 ]. After years of research, KD is considered an immune-mediated vasculitis [ 30 ]. Studies have found that T cells are mainly involved in KD's immune pathogenesis, including increased T cell activation and cytokine production, the proinflammatory (Th cells) and anti-inflammatory cells (Treg cells) imbalance [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease

Liao

Long³

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Aims. The clinical diagnosis of Kawasaki disease (KD) is not easy because of many atypical manifestations. This study is aimed at finding potential diagnostic markers and therapeutic targets for KD and analysing their correlation with immune cell infiltrations. Methods. First, we downloaded the KD dataset from the Gene Expression Omnibus (GEO) database and used R software to identify differentially expressed genes (DEGs) and perform functional correlation analysis. Then, CIBERSORT algorithm was used to evaluate immune cell infiltrations in samples. Coexpression analysis between DEGs and infiltrating immune cells was performed to screen the main infiltrating immune cells. Subsequently, the least absolute shrinkage and selection operator (LASSO) logistic regression analysis was used to screen the core genes related to KD. Finally, correlation analysis between the core genes and the main infiltrating immune cells was performed. Results. 327 DEGs were screened out in this study. Among them, 72 shared genes were the category of genes most likely to be disease-causing for they did not change before and after treatment. After analysis, it was found that expression level of IL2RB in KD tissues was significantly upregulated, the number of resting CD4+ memory T cells was decreased, and the decrease was significantly negatively correlated with the upregulated expression of IL2RB. Therefore, it was speculated that the upregulated expression of IL2RB disrupted Th1/Th2 cell differentiation balance, which led to a decrease of resting CD4+ memory T cells and finally caused disorder of immune microenvironment in patients with KD. Conclusions. Upregulated expression of IL2RB leads to disorder of immune microenvironment in patients with KD and eventually causes the occurrence and development of KD. Therefore, IL2RB may serve as a diagnostic marker and potential therapeutic target for KD.

show abstract

Section: Discussionmentioning

confidence: 99%

Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease

Liao

Long³

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…We considered the 30-day time point after KD diagnosis as the index date. To ensure that all of the included individuals had a new diagnosis of JIA, we excluded any pre-index-date diagnosis of JIA ( ICD-9-CM codes 714 and 720; ICD-10-CM codes M05, M06, M08, and M45) ( 14 ).…”

Section: Methodsmentioning

confidence: 99%

Impact of Kawasaki disease on juvenile idiopathic arthritis in real-world patients: A population-based cohort study

Liao

Chuang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

ObjectivesRecent research has demonstrated the commonality of several biological markers between Kawasaki disease (KD) and juvenile idiopathic arthritis (JIA), including interleukin-1β and -6. Therefore, in this cohort study, we assessed whether KD increases the risk of JIA.MethodsThis study enrolled 7009 patients with and 56 072 individuals without KD in the period 2010–2018 from Taiwan’s National Health Insurance Research Database. On the basis of sex, age, and comorbidities, we executed propensity score matching at the ratio 1:8. The adjusted hazard ratio (aHR) for JIA was determined through multiple Cox regression. Stratified analysis and sensitivity tests were also employed.ResultsWhen adjusting for age, sex, and comorbidities, the JIA risk was noted to be 2.02-fold greater in children with KD than it was in those without (aHR: 2.02, 95% confidence interval: 1.12–3.67, p = 0.0205). The sensitivity test and subgroup analysis obtained consistent findings in the different sex and comorbidity subgroups.ConclusionChildren’s risk of JIA is higher if they have KD. Pediatricians should consider the possibility of JIA in this population. More investigations are necessary to identify the pathological mechanisms that link JIA and KD.

show abstract

Clinical Characteristics of Kawasaki Disease in Children with Different Age Groups: A Literature Review and Retrospective Study

Tan

Huang

Shan

et al. 2023

CPD

View full text Add to dashboard Cite

Background and Objective: Kawasaki disease (KD) is an acute self-limiting systemic vascular disease commonly observed in children less than 5 years of age. The present study comparatively assesses the clinical characteristics of children diagnosed with KD in different age groups. Furthermore, a comprehensive literature review on the clinical features and diagnostic guidelines of KD is performed. Methods: This was a retrospective study conducted on KD children admitted to the Sun Yat-sen Memorial Hospital, Guangzhou, China, from January 2016 to December 2018. The children were divided into 3 age groups, including children <1 year of age (group A, n=66), 1-5 years of age (group B, n=74), and children > 5 years of age (group C, n=14). Complete clinical evaluation, hematological, and cardiovascular assessments were conducted and compared between the three groups. Results: The time of diagnosis, hemoglobin, and neutrophil ratio of children in group A were significantly lower than the other two groups (P <0.05), while the platelet count was significantly higher (P <0.05). The proportion of incomplete KD (iKD) was the greatest in group A (40.9%), while the proportion of children with increased coronary Z value and aseptic meningitis was greater than that in group B (P <0.0167). Group A showed less patients with KD shock syndrome (KDSS) than the other two groups (P <0.05). Group B showed the greatest number of patients with arthralgia compared to the other two groups (P <0.05). Three groups showed no significant difference in intravenous immunoglobulin (IVIG) therapy (P >0.05). Conclusion: The younger the age of KD onset, the more atypical the condition is, with a greater risk of affecting other systems and a higher incidence of coronary artery disease. An early treatment with glucocorticoids might be helpful in older children and those with a greater high-risk KD warning score to prevent coronary injury.

show abstract

Incidence of chronic immune-mediated inflammatory diseases after diagnosis with Kawasaki disease: a population-based cohort study

Cited by 3 publications

References 31 publications

Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease

Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease

Impact of Kawasaki disease on juvenile idiopathic arthritis in real-world patients: A population-based cohort study

Clinical Characteristics of Kawasaki Disease in Children with Different Age Groups: A Literature Review and Retrospective Study

Contact Info

Product

Resources

About