Incidence of Cholesteatoma with Cleft Palate

Dominguez, Steven; Harker, Lee A.

doi:10.1177/000348948809700614

Cited by 38 publications

(26 citation statements)

References 1 publication

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“…Excluding patients with cleft lip, the incidences of COM and cholesteatoma in cleft palate were 20% and 2% respectively. These figures are in broad agreement with those of Dominguez and Harker, 32 who reported an incidence of cholesteatoma among children with cleft palate in Iowa of 2.6%, and Moeller, 33 who reported an incidence in Norway of 0.9%. Our figures do not account for those children attending otolaryngology services elsewhere, some of whom may never have developed ear problems, and so may well represent a slight over‐estimate of the incidence of COM in cleft palate.…”

Section: Discussionsupporting

confidence: 90%

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Sequelae of otitis media with effusion among children with cleft lip and/or cleft palate1

et al. 2002

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Otitis media with effusion (OME) is common among children with cleft palate, and may lead to such long-term consequences as hearing loss, tympanic membrane retraction, and chronic otitis media (COM). In total, 104 children with cleft lip and/or palate treated for OME at our institution were reviewed. Mean duration of follow-up was 6.9 years, and mean age at latest follow-up was 9.6 years. The incidence of COM was 19%, and the incidence of cholesteatoma was 1.9%. Ears showing such long-term sequelae of OME as hearing loss, tympanic membrane retraction, and chronic otitis media, were noted to have undergone a significantly greater number of ventilation tube insertions than ears not showing these sequalae. Our findings would suggest that a conservative approach to the management of OME in children with cleft palate is more likely to be beneficial in the long term.

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Section: Discussionsupporting

confidence: 90%

“…The prevalence of chronic otitis media and cholesteatoma is high among patients with cleft palate, with the reported prevalences of cholesteatoma ranging from 0.9% to 9.2% 31–33 . In the present study, 20 out of 104 patients followed up at our department developed chronic otitis media (19%), with two developing a cholesteatoma (1.9%).…”

Section: Discussionmentioning

confidence: 41%

Sequelae of otitis media with effusion among children with cleft lip and/or cleft palate1

et al. 2002

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“…This was followed by accumulation of exfoliated keratin in this pocket with resultant cholesteatoma formation. The theory was supported experimentally by formation of cholesteatoma in 75% of Mongolian gerbils following bilateral Eustachian tube obstruction by electrocautery and also by higher incidence of cholesteatoma among patients with cleft palate in whom the Eustachian tube was malfunctioning [29,30]. Recently, Jackler et al [23] criticized the invagination theory in several respects.…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

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“…It has also to be noted that severe otologic complications, such as cholesteatoma, are nowadays rarely seen in palate cleft patients, which we believe can be attributed to a better awareness of the disease and to a more active treatment. Dominguez and Harker 11 reported a 9.2% risk for developing cholesteatoma at the University of Iowa Cleft Palate Clinic in palate cleft patients during the years 1947 and 1968. A comparable cohort of patients born between the years 1969 to 1977 were retrospectively reviewed, and only 2.6% of the patients developed cholesteatoma.…”

Section: Discussionmentioning

confidence: 99%

Long‐Term Clinical, Audiologic, and Radiologic Outcomes in Palate Cleft Children Treated with Early Tympanostomy for Otitis Media with Effusion: A Controlled Prospective Study

2005

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The prognosis of children with palate cleft treated with early tympanostomy is favorable and does not differ from children without palate cleft. Active treatment ensures normal hearing during the critical years of language, speech, and cognitive development and maintains the development of an aerated mastoid. We believe that early tympanostomy is the treatment of choice of OME in palate cleft children.

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Incidence of Cholesteatoma with Cleft Palate

Cited by 38 publications

References 1 publication

Sequelae of otitis media with effusion among children with cleft lip and/or cleft palate1

Sequelae of otitis media with effusion among children with cleft lip and/or cleft palate1

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Long‐Term Clinical, Audiologic, and Radiologic Outcomes in Palate Cleft Children Treated with Early Tympanostomy for Otitis Media with Effusion: A Controlled Prospective Study

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